Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Procyanidin A1 (Proanthocyanidin A1) has antiallergic effects, it inhibits degranulation downstream of protein kinase C activation or Ca2+; influx from an internal store in RBL-2H3 cells.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 18,500 | |||
5 mg | 在庫あり | ¥ 57,000 | |||
10 mg | 在庫あり | ¥ 85,000 | |||
25 mg | 在庫あり | ¥ 141,500 | |||
50 mg | 在庫あり | ¥ 199,500 | |||
100 mg | 在庫あり | ¥ 268,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 72,000 |
説明 | Procyanidin A1 (Proanthocyanidin A1) has antiallergic effects, it inhibits degranulation downstream of protein kinase C activation or Ca2+; influx from an internal store in RBL-2H3 cells. |
In vitro | We found that a peanut-skin extract (PSE) inhibits the degranulation induced by antigen stimulation of rat basophilic leukemia (RBL-2H3) cells. A low-molecular-weight fraction from PSE, PSEL, also had inhibitory activity against allergic degranulation. A main polyphenol in PSEL was purified by gel chromatography and fractionated by YMC-gel ODS-AQ 120S50 column. Electrospray ionization mass spectrometry (ESI-MS) analysis of the purified polyphenol gave m/z 599 [M+Na]?. Based on the results of 1H-NMR, 13C-NMR spectra, and optical rotation analysis, the polyphenol was identified as Procyanidin A1. It inhibited the degranulation caused by antigen stimulation at the IC50 of 20.3 μM. Phorbol-12-myristate-13-acetate (PMA) and 2,5,-di(tert-butyl)-1,4-hydroquinone (DTBHQ)-induced processes of degranulation were also inhibited by Procyanidin A1[1] |
植物由来 |
別名 | Proanthocyanidin A1 |
分子量 | 576.5 |
分子式 | C30H24O12 |
CAS No. | 103883-03-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/mL (95.4 mM)
You can also refer to dose conversion for different animals. 詳細
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Procyanidin A1 103883-03-0 Chromatin/Epigenetic Cytoskeletal Signaling Membrane transporter/Ion channel Metabolism PKC Calcium Channel LDL Inhibitor Proanthocyanidin A 1 Procyanidin A 1 Protein kinase C inhibit Proanthocyanidin A1 Proanthocyanidin A-1 Procyanidin A-1 inhibitor