Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SBP-7455 potently inhibited ULK1/2 enzymatic activity in vitro and in cells, reduced the viability of TNBC cells and had oral bioavailability in mice.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 13,500 | |||
5 mg | 在庫あり | ¥ 28,000 | |||
10 mg | 在庫あり | ¥ 46,500 | |||
25 mg | 在庫あり | ¥ 83,500 | |||
50 mg | 在庫あり | ¥ 136,500 | |||
100 mg | 在庫あり | ¥ 171,000 |
説明 | SBP-7455 potently inhibited ULK1/2 enzymatic activity in vitro and in cells, reduced the viability of TNBC cells and had oral bioavailability in mice. |
ターゲット&IC50 | Autophagy:0.3 μM |
In vitro | SBP-7455 treatment inhibits cell growth with an IC50 of 0.3 μM for MDA-MB-468 cells. SBP-7455 inhibits starvation-induced autophagic flux in TNBC cells that are dependent on autophagy for survival[1]. |
In vivo | To evaluate the PD profile and in vivo target engagement, mice were dosed with SBP-7455 (10 mg/kg) or vehicle by oral gavage, and liver samples were collected after 2 h.Based on the PK and PD profiles, our data show that SBP-7455 is an efficacious tool that can be used to modulate autophagy in vivop[1]. |
分子量 | 354.33 |
分子式 | C16H17F3N4O2 |
CAS No. | 1884222-74-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 120mg/mL (338.67 mM)
You can also refer to dose conversion for different animals. 詳細
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sbp-7455 1884222-74-5 Autophagy SBP-7455 ULK TNBC ULK2 ULK1 Unc-51 like kinase sbp7455 Ser318 sbp 7455 Inhibitor inhibit pATG13 oral inhibitor