Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ULK1-IN-2 is a potent ULK1 inhibitor with potential anticancer activity, inducing apoptosis while blocking autophagy.ULK1-IN-2 has high cytotoxicity against cancer cells, with an IC50 value of 1.94 μM against A549 cells.ULK1-IN-2 can be used for the study of non-small-cell lung cancer.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 12,000 | |||
5 mg | 在庫あり | ¥ 28,000 | |||
10 mg | 在庫あり | ¥ 45,500 | |||
25 mg | 在庫あり | ¥ 104,500 | |||
50 mg | 在庫あり | ¥ 158,500 | |||
100 mg | 在庫あり | ¥ 257,000 | |||
500 mg | 在庫あり | ¥ 512,000 |
説明 | ULK1-IN-2 is a potent ULK1 inhibitor with potential anticancer activity, inducing apoptosis while blocking autophagy.ULK1-IN-2 has high cytotoxicity against cancer cells, with an IC50 value of 1.94 μM against A549 cells.ULK1-IN-2 can be used for the study of non-small-cell lung cancer. |
In vitro | ULK1-IN-2 (compound 3s) (10 μM; 24 h) exhibits potent anti-proliferative activity against A549, U937, HL60, MDA-MB-468, and MCF-7 cells. In A549 cells, ULK1-IN-2 hinders autophagy by inhibiting ULK1. Furthermore, ULK1-IN-2 induces apoptosis through the mitochondrial pathways in A549 cells in a dose-dependent manner and inhibits ULK1 and p-ULK1ser317 expression in a concentration-dependent manner, leading to Bcl-2 expression significantly decrease and an increase in Bax and the active form of Caspase-3 expression.[1] |
分子量 | 495.26 |
分子式 | C19H16BrFN4O6 |
CAS No. | 2497409-01-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 30 mg/mL (60.57 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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ULK1-IN-2 2497409-01-3 Apoptosis Autophagy Inhibitor inhibitor inhibit