Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Zabedosertib (BAY 1834845) is an inhibitor of IRAK4 with immunomodulatory potential. Zabedosertib protects against acute respiratory distress syndrome, a new study suggests.
説明 | Zabedosertib (BAY 1834845) is an inhibitor of IRAK4 with immunomodulatory potential. Zabedosertib protects against acute respiratory distress syndrome, a new study suggests. |
ターゲット&IC50 | IRAK4:3.55 nM |
In vivo | In an inhaled lipopolysaccharide (LPS)-induced ARDS mouse model, BAY-1834845 downregulated genes more efficiently than dexamethasone, especially TNF, IL-17, interferon, and Toll-like receptor signaling[1]. |
別名 | BAY 1834845 |
分子量 | 470.47 |
分子式 | C20H21F3N4O4S |
CAS No. | 1931994-81-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 112.5 mg/mL (239.1 mM), Sonication and heating to 60℃ are recommended.
You can also refer to dose conversion for different animals. 詳細
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Zabedosertib 1931994-81-8 Immunology/Inflammation NF-Κb IRAK BAY 1834845 BAY1834845 BAY-1834845 Inhibitor inhibitor inhibit