Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Zapnometinib (ATR-002) is a MEK inhibitor.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
5 mg | 在庫あり | ¥ 9,500 | |||
10 mg | 在庫あり | ¥ 14,000 | |||
25 mg | 在庫あり | ¥ 17,000 | |||
50 mg | 在庫あり | ¥ 32,000 | |||
100 mg | 在庫あり | ¥ 62,500 | |||
200 mg | 在庫あり | ¥ 91,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 12,000 |
説明 | Zapnometinib (ATR-002) is a MEK inhibitor. |
ターゲット&IC50 | MEK:5.7 nM |
In vitro | Zapnometinib inhibits MEK, with IC50s of 30.96 nM, 357 nM, and 15 nM in cell free kinase assay, A549, MDCK cells and human PBMCs[1].Zapnometinib reduces the viral titers of the IV H1N1pdm09, H3N2[1]. |
In vivo | Zapnometinib exhibits AUC values of 860.02 and 1953.68 μg?h/mL in mice by i.v. or oral route, respectively[1].Zapnometinib reduces the lung virus titers and enhances survival of mice after lethal H1N1pdm09 infection[1]. |
別名 | ATR-002, 3,4-difluoro-2-(2-chloro-4-iodophenylaMino)-benzoic acid, PD0184264, 2-(2-chloro-4-iodoanilino)-3,4-difluorobenzoic acid |
分子量 | 409.55 |
分子式 | C13H7ClF2INO2 |
CAS No. | 303175-44-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 60 mg/mL (146.50 mM)
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
zapnometinib 303175-44-2 MAPK Microbiology/Virology Antibacterial Influenza Virus MEK antiviral virus MAPKK Bacterial PD-0184264 CI-1040 ATR 002 Inhibitor ATR-002 Mitogen-activated protein kinase kinase antibacterial 3,4-difluoro-2-(2-chloro-4-iodophenylaMino)-benzoic acid inhibit ATR002 influenza PD0184264 PD 0184264 2-(2-chloro-4-iodoanilino)-3,4-difluorobenzoic acid MAP2K inhibitor