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カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T6152 | PD318088 | MEK | |
PD318088 is a non-ATP competitive allosteric MEK1/2 inhibitor, binding simultaneously with ATP in a region of the MEK1 active site that is adjacent to the ATP-binding site. | |||
T6692 | TAK-733 | TAK733,TAK 733 | MEK |
TAK-733 is an orally bioavailable small-molecule inhibitor of MEK1 and MEK2 (MEK1/2) with potential antineoplastic activity. | |||
T2708 | SL327 | SL 327,SL-327 | MEK , DNA/RNA Synthesis |
SL327 is a selective inhibitor for MEK1/2 with IC50 of 0.18 μM/0.22 μM; able to transport through the blood-brain barrier. | |||
T6785 | BI-847325 | Apoptosis , MEK , Aurora Kinase | |
BI-847325 is a selective dual inhibitor of MEK and aurora kinases (AK) with IC50 values of 4 and 15 nM for human MEK2 and AK-C, respectively. | |||
T21635 | PD184161 | MEK | |
PD184161 is a novel, orally-active MEK inhibitor. PD184161 inhibited MEK activity (IC50 = 10-100 nM) in a time- and concentration-dependent manner[1]. | |||
T21295 | BIX02189 | BIX 02189 | ERK , MEK |
BIX02189 is a potent and selective inhibitor of MEK5 and ERK5(IC50 : 1.5 nM and 59 nM). | |||
T2443 | CI-1040 | PD 184352 | Apoptosis , MEK |
CI-1040 (PD 184352) (PD184352) is an ATP non-competitive MEK1/2 inhibitor (IC50: 17 nM). | |||
T7610 | GW284543 | UNC10225170 | MEK |
GW284543 (UNC10225170) is a selective inhibitor of MEK5 . | |||
T2623 | PD98059 | PD 98059 | ERK , Aryl Hydrocarbon Receptor , MEK , Autophagy |
PD98059 is an MEK inhibitor that inhibits MEK1 and MEK2 (IC50=2/50 μM) and is non-ATP-competitive. PD98059 is also antagonistic as a ligand for AHR. PD98059 inhibits autophagy. | |||
T21980 | PD 198306 | MEK | |
PD 198306 is a selective inhibitor of MAPK/ERK-kinase (MEK) with antihyperalgesic effects. PD 198306 reduces the Streptozocin-induced increase in the level of active ERK1. | |||
T5412 | RO4987655 | CH4987655,RG7167 | MEK |
RO4987655 (RG7167) is an orally active and highly selective MEK inhibitor (IC50: 5.2 nM for MEK1/MEK2). | |||
T1144L | Lidocaine Hydrochloride hydrate | EGFR , Sodium Channel | |
Lidocaine Hydrochloride hydrate is an amide local anesthetic, has anti-inflammatory property. | |||
T6218 | Selumetinib | ARRY-142886,AZD6244 | Apoptosis , ERK , MEK |
Selumetinib (AZD6244) (AZD6244) is an effective, specific inhibitor of MEK1 and ERK1/2 phosphorylation (IC50: 14/10 nM). | |||
T6189 | Mirdametinib | PD325901,PD0325901 | Apoptosis , MEK , Autophagy |
Mirdametinib (PD325901) is an MEK inhibitor (IC50=0.33 nM) with selective, non-ATP-competitive, and oral activity. Mirdametinib exhibits antitumor activity by inhibiting p-ERK1/2 expression and inducing apoptosis. | |||
T6971 | Ro 5126766 | CH5126766,Avutometinib,VS-6766,RO5126766 | Raf , MEK |
RO5126766 (CH5126766) is a dual RAF/MEK inhibitor with IC50 of 8.2 nM, 19 nM, 56 nM, and 160 nM for BRAF V600E, BRAF, CRAF, and MEK1, respectively. Phase 1. | |||
T0468 | Lidocaine | Lignocaine,Alphacaine,Xylocaine | Apoptosis , ERK , NF-κB , MEK , Sodium Channel , Histamine Receptor |
Lidocaine (Alphacaine) is an amide local anesthetic with anti-inflammatory properties in vitro and in vivo. It has this functions perhaps due to an attenuation of intracellular adhesion molecule-1 (ICAM-1), pro-inflammat... | |||
T6760 | APS-2-79 hydrochloride | APS-2-79 HCl,APS-2-79 | MEK , MAPK |
APS-2-79 hydrochloride (APS-2-79 HCl) is a MAPK antagonist that modulating KSR-dependent MAPK signalling by antagonizing RAF heterodimerization as well as the conformational changes required for phosphorylation and activ... | |||
T2508 | Binimetinib | ARRY-438162,ARRY-162,MEK162 | MEK , Autophagy |
Binimetinib (ARRY-162) (MEK162, ARRY-162, ARRY-438162) is an orally available inhibitor of MEK1/2 (IC50: 12 nM) in a cell-free assay. | |||
T2125 | Trametinib | GSK1120212,JTP-74057 | Apoptosis , MEK , Autophagy |
Trametinib (GSK1120212) is a MEK inhibitor that inhibits MEK1 and MEK2 (IC50=0.7/0.9 nM) with ATP non-competitive and oral activity. Trametinib activates autophagy and induces apoptosis. | |||
T6223 | U0126-EtOH | U0126 Ethanol,U0126 | Mitophagy , Influenza Virus , MEK , Autophagy |
U0126-EtOH (U0126 Ethanol) is a non-ATP competitive specific inhibitor of MEK1/2 (IC50: 0.07/0.06 μM). | |||
T6083 | AZD8330 | ARRY-424704,ARRY-704 | ERK , MEK |
AZD8330 (ARRY-704) is a novel, selective, non-ATP competitive MEK 1/2 inhibitor with IC50 of 7 nM. Phase 1. | |||
T2378 | RGB-286638 free base | GSK-3 , MEK , JAK , CDK | |
RGB-286638 free base is a novel CDK inhibitor with IC50s of 1 nM/2 nM/3 nM/4 nM/5 nM for cyclin T1-CDK9/cyclin B1-CDK1/cyclin E-CDK2/cyclin D1-CDK4/cyclin E-CDK3/p35-CDK5 respectively; less potent against cyclin H-CDK7 a... | |||
T6636 | Refametinib | BAY 86-97661,BAY 869766,RDEA119 | MEK |
Refametinib (RDEA119) (RDEA119, Bay 86-9766) is an effective, ATP non-competitive and specific inhibitor of MEK1/2 (IC50: 19/47 nM). | |||
T6843 | GDC-0623 | G-868,GDC0623,RG 7421,MEK inhibitor 1 | Apoptosis , MEK |
GDC-0623 (RG 7421) is a potent and ATP-uncompetitive MEK1 inhibitor with Ki of 0.13 nM. Phase 1. | |||
T3623 | Cobimetinib | RG7420,XL518,GDC-0973 | Apoptosis , MEK |
Cobimetinib (GDC-0973) is a selective inhibitor of mitogen-activated protein kinase kinase (MEK) (IC50: 0.9 nM). Cobimetinib specifically binds to and inhibits the catalytic activity of MEK1, resulting in inhibition of e... | |||
T6131 | Pimasertib | AS703026,MSC1936369B,SAR 245509 | MEK |
Pimasertib (AS703026) is an orally bioavailable small-molecule inhibitor of MEK1 and MEK2 (MEK1/2) with potential antineoplastic activity. | |||
T1144 | Lidocaine hydrochloride | Lidocaine HCL,Lignocaine hydrochloride,Xyloneural,Lidothesin | Apoptosis , ERK , NF-κB , MEK , Sodium Channel |
Lidocaine hydrochloride (Lignocaine hydrochloride) is a local anesthetic and cardiac depressant used as an antiarrhythmic agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its ... | |||
T5857 | Trametinib (DMSO solvate) | Trametinib DMSO solvate,GSK-1120212 (DMSO solvate),Trametinib dimethyl sulfoxide,JTP-74057 (DMSO solvate) | Apoptosis , MEK |
Trametinib (DMSO solvate) (GSK-1120212 (DMSO solvate)) is a Highly Potent and Selective MEK Inhibitor that specifically inhibits MEK1/2(IC50 :2 nM) | |||
T9321 | Zapnometinib | ATR-002,3,4-difluoro-2-(2-chloro-4-iodophenylaMino)-benzoic acid,PD0184264,2-(2-chloro-4-iodoanilino)-3,4-difluorobenzoic acid | Influenza Virus , MEK , Antibacterial |
Zapnometinib (ATR-002) is a MEK inhibitor. | |||
T21332 | U0126 | U 0126,U-0126 | Mitophagy , MEK , Autophagy |
U0126, an effective and selective non-competitive inhibitor of MAP kinase, inhibits MEK-1 and MEK-2 with IC50 values of 0.07 and 0.06 μM respectively. U0126 inhibits autophagy and mitophagy. | |||
T22677 | Cobimetinib racemate | Cobimetinib (racemate) | MEK |
Cobimetinib racemate (Cobimetinib (racemate)) (GDC-0973 racemate) is a selective inhibitor of MEK.Cobimetinib racemate is also known as a mitogen-activated protein kinase, is a key component of the RAS/RAF/MEK/ERK pathwa... |
カタログ番号 | 製品名 | 別名 | ターゲット |
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TMS2181 | Trans-Zeatin | (E)-Zeatin | ERK , MEK , Endogenous Metabolite |
trans-Zeatin ((E)-Zeatin) is the member of the plant growth hormone family known as cytokinins, which regulate cell division, development, and nutrient processing. | |||
T7030 | Anemarsaponin B | p38 MAPK , NF-κB , MEK , COX , NO Synthase | |
Anemarsaponin B has anti-inflammatory effect in LPS-treated RAW 264.7macrophages, the effect is associated with the inhibition of NF-κB transcriptional activity, possibly via the p38 MAP kinase pathway. Anemarsaponin B c... | |||
T2836 | Isorhamnetin | 3-methylquercetin,3'-Methylquercetin,Isorhamnetol,3'-Methoxyquercetin | MEK , PI3K , Endogenous Metabolite |
Isorhamnetin (3-methylquercetin) is the methylated metabolite of quercetin. Quercetin is an important dietary flavonoid with in vitro antioxidant activity. Isorhamnetin prevents endothelial cell injuries from oxidized LD... |
カタログ番号 | 製品名 | Species | Expression System |
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TMPH-01250 | MAP2K3 Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38. Part of a signaling cascade that... |