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カタログ番号	製品名	別名	ターゲット
T6152	PD318088		MEK
	PD318088 is a non-ATP competitive allosteric MEK1/2 inhibitor, binding simultaneously with ATP in a region of the MEK1 active site that is adjacent to the ATP-binding site.		MEK
T6692	TAK-733	TAK733,TAK 733	MEK
	TAK-733 is an orally bioavailable small-molecule inhibitor of MEK1 and MEK2 (MEK1/2) with potential antineoplastic activity.		MEK
T2708	SL327	SL 327,SL-327	MEK , DNA/RNA Synthesis
	SL327 is a selective inhibitor for MEK1/2 with IC50 of 0.18 μM/0.22 μM; able to transport through the blood-brain barrier.		MEK , DNA/RNA Synthesis
T6785	BI-847325		Apoptosis , MEK , Aurora Kinase
	BI-847325 is a selective dual inhibitor of MEK and aurora kinases (AK) with IC50 values of 4 and 15 nM for human MEK2 and AK-C, respectively.		Apoptosis , MEK , Aurora Kinase
T21635	PD184161		MEK
	PD184161 is a novel, orally-active MEK inhibitor. PD184161 inhibited MEK activity (IC50 = 10-100 nM) in a time- and concentration-dependent manner[1].		MEK
T21295	BIX02189	BIX 02189	ERK , MEK
	BIX02189 is a potent and selective inhibitor of MEK5 and ERK5(IC50 : 1.5 nM and 59 nM).		ERK , MEK
T2443	CI-1040	PD 184352	Apoptosis , MEK
	CI-1040 (PD 184352) (PD184352) is an ATP non-competitive MEK1/2 inhibitor (IC50: 17 nM).		Apoptosis , MEK
T7610	GW284543	UNC10225170	MEK
	GW284543 (UNC10225170) is a selective inhibitor of MEK5 .		MEK
T2623	PD98059	PD 98059	ERK , Aryl Hydrocarbon Receptor , MEK , Autophagy
	PD98059 is an MEK inhibitor that inhibits MEK1 and MEK2 (IC50=2/50 μM) and is non-ATP-competitive. PD98059 is also antagonistic as a ligand for AHR. PD98059 inhibits autophagy.		ERK , Aryl Hydrocarbon Receptor , MEK , Autophagy
T21980	PD 198306		MEK
	PD 198306 is a selective inhibitor of MAPK/ERK-kinase (MEK) with antihyperalgesic effects. PD 198306 reduces the Streptozocin-induced increase in the level of active ERK1.		MEK
T5412	RO4987655	CH4987655,RG7167	MEK
	RO4987655 (RG7167) is an orally active and highly selective MEK inhibitor (IC50: 5.2 nM for MEK1/MEK2).		MEK
T6189	Mirdametinib	PD325901,PD0325901	Apoptosis , MEK , Autophagy
	Mirdametinib (PD325901) is an MEK inhibitor (IC50=0.33 nM) with selective, non-ATP-competitive, and oral activity. Mirdametinib exhibits antitumor activity by inhibiting p-ERK1/2 expression and inducing apoptosis.		Apoptosis , MEK , Autophagy
T1144L	Lidocaine Hydrochloride hydrate		EGFR , Sodium Channel
	Lidocaine Hydrochloride hydrate is an amide local anesthetic, has anti-inflammatory property.		EGFR , Sodium Channel
T6218	Selumetinib	ARRY-142886,AZD6244	Apoptosis , ERK , MEK
	Selumetinib (AZD6244) (AZD6244) is an effective, specific inhibitor of MEK1 and ERK1/2 phosphorylation (IC50: 14/10 nM).		Apoptosis , ERK , MEK
T6971	Ro 5126766	CH5126766,Avutometinib,VS-6766,RO5126766	Raf , MEK
	RO5126766 (CH5126766) is a dual RAF/MEK inhibitor with IC50 of 8.2 nM, 19 nM, 56 nM, and 160 nM for BRAF V600E, BRAF, CRAF, and MEK1, respectively. Phase 1.		Raf , MEK
T6760	APS-2-79 hydrochloride	APS-2-79 HCl,APS-2-79	MEK , MAPK
	APS-2-79 hydrochloride (APS-2-79 HCl) is a MAPK antagonist that modulating KSR-dependent MAPK signalling by antagonizing RAF heterodimerization as well as the conformational changes required for phosphorylation and activ...		MEK , MAPK
T0468	Lidocaine	Lignocaine,Alphacaine,Xylocaine	Apoptosis , ERK , NF-κB , MEK , Sodium Channel , Histamine Receptor
	Lidocaine (Alphacaine) is an amide local anesthetic with anti-inflammatory properties in vitro and in vivo. It has this functions perhaps due to an attenuation of intracellular adhesion molecule-1 (ICAM-1), pro-inflammat...
T6223	U0126-EtOH	U0126 Ethanol,U0126	Mitophagy , Influenza Virus , MEK , Autophagy
	U0126-EtOH (U0126 Ethanol) is a non-ATP competitive specific inhibitor of MEK1/2 (IC50: 0.07/0.06 μM).		Mitophagy , Influenza Virus , MEK , Autophagy
T6083	AZD8330	ARRY-424704,ARRY-704	ERK , MEK
	AZD8330 (ARRY-704) is a novel, selective, non-ATP competitive MEK 1/2 inhibitor with IC50 of 7 nM. Phase 1.		ERK , MEK
T2508	Binimetinib	ARRY-438162,ARRY-162,MEK162	MEK , Autophagy
	Binimetinib (ARRY-162) (MEK162, ARRY-162, ARRY-438162) is an orally available inhibitor of MEK1/2 (IC50: 12 nM) in a cell-free assay.		MEK , Autophagy
T2125	Trametinib	GSK1120212,JTP-74057	Apoptosis , MEK , Autophagy
	Trametinib (GSK1120212) is a MEK inhibitor that inhibits MEK1 and MEK2 (IC50=0.7/0.9 nM) with ATP non-competitive and oral activity. Trametinib activates autophagy and induces apoptosis.		Apoptosis , MEK , Autophagy
T2378	RGB-286638 free base		GSK-3 , MEK , JAK , CDK
	RGB-286638 free base is a novel CDK inhibitor with IC50s of 1 nM/2 nM/3 nM/4 nM/5 nM for cyclin T1-CDK9/cyclin B1-CDK1/cyclin E-CDK2/cyclin D1-CDK4/cyclin E-CDK3/p35-CDK5 respectively; less potent against cyclin H-CDK7 a...		GSK-3 , MEK , JAK , CDK
T6636	Refametinib	BAY 86-97661,BAY 869766,RDEA119	MEK
	Refametinib (RDEA119) (RDEA119, Bay 86-9766) is an effective, ATP non-competitive and specific inhibitor of MEK1/2 (IC50: 19/47 nM).		MEK
T6843	GDC-0623	G-868,GDC0623,RG 7421,MEK inhibitor 1	Apoptosis , MEK
	GDC-0623 (RG 7421) is a potent and ATP-uncompetitive MEK1 inhibitor with Ki of 0.13 nM. Phase 1.		Apoptosis , MEK
T3623	Cobimetinib	RG7420,XL518,GDC-0973	Apoptosis , MEK
	Cobimetinib (GDC-0973) is a selective inhibitor of mitogen-activated protein kinase kinase (MEK) (IC50: 0.9 nM). Cobimetinib specifically binds to and inhibits the catalytic activity of MEK1, resulting in inhibition of e...		Apoptosis , MEK
T6131	Pimasertib	AS703026,MSC1936369B,SAR 245509	MEK
	Pimasertib (AS703026) is an orally bioavailable small-molecule inhibitor of MEK1 and MEK2 (MEK1/2) with potential antineoplastic activity.		MEK
T1144	Lidocaine hydrochloride	Lidocaine HCL,Lignocaine hydrochloride,Xyloneural,Lidothesin	Apoptosis , ERK , NF-κB , MEK , Sodium Channel
	Lidocaine hydrochloride (Lignocaine hydrochloride) is a local anesthetic and cardiac depressant used as an antiarrhythmic agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its ...		Apoptosis , ERK , NF-κB , MEK , Sodium Channel
T5857	Trametinib (DMSO solvate)	Trametinib DMSO solvate,GSK-1120212 (DMSO solvate),Trametinib dimethyl sulfoxide,JTP-74057 (DMSO solvate)	Apoptosis , MEK
	Trametinib (DMSO solvate) (GSK-1120212 (DMSO solvate)) is a Highly Potent and Selective MEK Inhibitor that specifically inhibits MEK1/2(IC50 :2 nM)		Apoptosis , MEK
T9321	Zapnometinib	ATR-002,3,4-difluoro-2-(2-chloro-4-iodophenylaMino)-benzoic acid,PD0184264,2-(2-chloro-4-iodoanilino)-3,4-difluorobenzoic acid	Influenza Virus , MEK , Antibacterial
	Zapnometinib (ATR-002) is a MEK inhibitor.		Influenza Virus , MEK , Antibacterial
T21332	U0126	U 0126,U-0126	Mitophagy , MEK , Autophagy
	U0126, an effective and selective non-competitive inhibitor of MAP kinase, inhibits MEK-1 and MEK-2 with IC50 values of 0.07 and 0.06 μM respectively. U0126 inhibits autophagy and mitophagy.		Mitophagy , MEK , Autophagy
T22677	Cobimetinib racemate	Cobimetinib (racemate)	MEK
	Cobimetinib racemate (Cobimetinib (racemate)) (GDC-0973 racemate) is a selective inhibitor of MEK.Cobimetinib racemate is also known as a mitogen-activated protein kinase, is a key component of the RAS/RAF/MEK/ERK pathwa...		MEK
T70317	BIBU-1361 dihydrochloride
	BIBU-1361 dihydrochloride is an inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase that blocks downstream EGFR signaling events such as MAPKK/MAPK activation.

Compounds

Synonym: TAK733,TAK 733

Target: MEK

SL327

T2708

Synonym: SL 327,SL-327

Target: MEK, DNA/RNA Synthesis

BI-847325

T6785

Synonym:

Target: Apoptosis, MEK, Aurora Kinase

Target: Apoptosis, MEK

Target: ERK, Aryl Hydrocarbon Receptor, MEK, Autophagy

Synonym: CH4987655,RG7167

Target: MEK

Mirdametinib

T6189

Synonym: PD325901,PD0325901

Target: Apoptosis, MEK, Autophagy

Lidocaine Hydrochloride hydrate

T1144L

Synonym:

Target: EGFR, Sodium Channel

Selumetinib

T6218

Synonym: ARRY-142886,AZD6244

Target: Apoptosis, ERK, MEK

Ro 5126766

T6971

Synonym: CH5126766,Avutometinib,VS-6766,RO5126766

Target: Raf, MEK

APS-2-79 hydrochloride

T6760

Synonym: APS-2-79 HCl,APS-2-79

Target: MEK, MAPK

Lidocaine

T0468

Synonym: Lignocaine,Alphacaine,Xylocaine

Target: Apoptosis, ERK, NF-κB, MEK, Sodium Channel, Histamine Receptor

U0126-EtOH

T6223

Synonym: U0126 Ethanol,U0126

Target: Mitophagy, Influenza Virus, MEK, Autophagy

AZD8330

T6083

Synonym: ARRY-424704,ARRY-704

Target: ERK, MEK

Binimetinib

T2508

Synonym: ARRY-438162,ARRY-162,MEK162

Target: MEK, Autophagy

Trametinib

T2125

Synonym: GSK1120212,JTP-74057

Target: Apoptosis, MEK, Autophagy

RGB-286638 free base

T2378

Synonym:

Target: GSK-3, MEK, JAK, CDK

Refametinib

T6636

Synonym: BAY 86-97661,BAY 869766,RDEA119

Target: MEK

GDC-0623

T6843

Synonym: G-868,GDC0623,RG 7421,MEK inhibitor 1

Target: Apoptosis, MEK

Cobimetinib

T3623

Synonym: RG7420,XL518,GDC-0973

Target: Apoptosis, MEK

Pimasertib

T6131

Synonym: AS703026,MSC1936369B,SAR 245509

Target: MEK

Lidocaine hydrochloride

T1144

Synonym: Lidocaine HCL,Lignocaine hydrochloride,Xyloneural,Lidothesin

Target: Apoptosis, ERK, NF-κB, MEK, Sodium Channel

Trametinib (DMSO solvate)

T5857

Synonym: Trametinib DMSO solvate,GSK-1120212 (DMSO solvate),Trametinib dimethyl sulfoxide,JTP-74057 (DMSO solvate)

Target: Apoptosis, MEK

zapnometinib

T9321

Synonym: ATR-002,3,4-difluoro-2-(2-chloro-4-iodophenylaMino)-benzoic acid,PD0184264,2-(2-chloro-4-iodoanilino)-3,4-difluorobenzoic acid

Target: Influenza Virus, MEK, Antibacterial

U0126

T21332

Synonym: U 0126,U-0126

Target: Mitophagy, MEK, Autophagy

Cobimetinib racemate

T22677

Synonym: Cobimetinib (racemate)

Target: MEK

BIBU-1361 dihydrochloride

T70317

Synonym:

Target:

カタログ番号	製品名	別名	ターゲット
TMS2181	Trans-Zeatin	(E)-Zeatin	ERK , MEK , Endogenous Metabolite
	trans-Zeatin ((E)-Zeatin) is the member of the plant growth hormone family known as cytokinins, which regulate cell division, development, and nutrient processing.		ERK , MEK , Endogenous Metabolite
T7030	Anemarsaponin B		p38 MAPK , NF-κB , MEK , COX , NO Synthase
	Anemarsaponin B has anti-inflammatory effect in LPS-treated RAW 264.7macrophages, the effect is associated with the inhibition of NF-κB transcriptional activity, possibly via the p38 MAP kinase pathway. Anemarsaponin B c...		p38 MAPK , NF-κB , MEK , COX , NO Synthase
T2836	Isorhamnetin	3-methylquercetin,3'-Methylquercetin,Isorhamnetol,3'-Methoxyquercetin	MEK , PI3K , Endogenous Metabolite
	Isorhamnetin (3-methylquercetin) is the methylated metabolite of quercetin. Quercetin is an important dietary flavonoid with in vitro antioxidant activity. Isorhamnetin prevents endothelial cell injuries from oxidized LD...		MEK , PI3K , Endogenous Metabolite

天然物製品

trans-Zeatin

TMS2181

Synonym: (E)-Zeatin

Target: ERK, MEK, Endogenous Metabolite

anemarsaponin B

T7030

Synonym:

Target: p38 MAPK, NF-κB, MEK, COX, NO Synthase

Isorhamnetin

T2836

Synonym: 3-methylquercetin,3'-Methylquercetin,Isorhamnetol,3'-Methoxyquercetin

Target: MEK, PI3K, Endogenous Metabolite

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPY-04756	MEK1 Protein, Mouse, Recombinant	Mouse	Baculovirus-Insect Cells
	MEK1, also known as MAP2K1 and MKK1, is a member of the dual-specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kin...
TMPY-04569	MEK1 Protein, Mouse, Recombinant (His & GST)	Mouse	Baculovirus-Insect Cells
	MEK1, also known as MAP2K1 and MKK1, is a member of the dual-specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kin...
TMPY-04365	MKK6 Protein, Human, Recombinant (S207D, T211D, His & GST)	Human	Baculovirus-Insect Cells
	Dual specificity mitogen-activated protein kinase kinase 6, also known as MAP kinase kinase 6, MAPKK 6, MAPK / ERK kinase 6, SAPKK3, MAP2K6, and MKK6, is a protein that belongs to the protein kinase superfamily, STE Ser ...
TMPY-04748	MKK6 Protein, Human, Recombinant	Human	Baculovirus-Insect Cells
	Dual specificity mitogen-activated protein kinase kinase 6, also known as MAP kinase kinase 6, MAPKK 6, MAPK / ERK kinase 6, SAPKK3, MAP2K6, and MKK6, is a protein that belongs to the protein kinase superfamily, STE Ser ...
TMPY-04364	MKK6 Protein, Human, Recombinant (His & GST)	Human	Baculovirus-Insect Cells
	Dual specificity mitogen-activated protein kinase kinase 6, also known as MAP kinase kinase 6, MAPKK 6, MAPK / ERK kinase 6, SAPKK3, MAP2K6, and MKK6, is a protein that belongs to the protein kinase superfamily, STE Ser ...
TMPY-04749	MKK6 Protein, Human, Recombinant (S207D, T211D)	Human	Baculovirus-Insect Cells
	Dual specificity mitogen-activated protein kinase kinase 6, also known as MAP kinase kinase 6, MAPKK 6, MAPK / ERK kinase 6, SAPKK3, MAP2K6, and MKK6, is a protein that belongs to the protein kinase superfamily, STE Ser ...
TMPY-04544	MEK2 Protein, Human, Recombinant (GST)	Human	Baculovirus-Insect Cells
	Dual specificity mitogen-activated protein kinase kinase 2, also known as MAP kinase kinase 2, MAPKK2, ERK activator kinase 2, MAPK / ERK kinase 2, MEK2 and MAP2K2, is a member of the protein kinase superfamily, STE Ser/...
TMPY-04572	MKK4 Protein, Mouse, Recombinant (His & GST)	Mouse	Baculovirus-Insect Cells
	Dual specificity mitogen-activated protein kinase kinase 4, also known as MAP kinase kinase 4, MAPKK4, JNK-activating kinase 1, MAPK/ERK kinase 4, SAPK/ERK kinase 1, c-Jun N-terminal kinase kinase 1, JNKK, and MAP2K4, is...
TMPY-04547	PBK/TOPK Protein, Human, Recombinant (His)	Human	Baculovirus-Insect Cells
	PDZ binding kinase (PBK), also known as TOPK (T-LAK cell-originated protein kinase), is a serine/threonine kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family, and has all the chara...