The insulin-like growth factors (IGFs) are proteins with high sequence similarity to insulin. IGFs are part of a complex system that cells use to communicate with their physiologic environment. This complex system (often referred to as the IGF "axis") consists of two cell-surface receptors (IGF1R and IGF2R), two ligands (IGF-1 and IGF-2), a family of seven high-affinity IGF-binding proteins (IGFBP1 to IGFBP7), as well as associated IGFBP degrading enzymes, referred to collectively as proteases. The IGF "axis" is also commonly referred to as the Growth Hormone/IGF-1 Axis. Insulin-like growth factor 1 (IGF-1) is mainly secreted by the liver as a result of stimulation by growth hormone (GH). IGF-1 is important for both the regulation of normal physiology, as well as a number of pathological states, including cancer. The IGF axis has been shown to play roles in the promotion of cell proliferation and the inhibition of cell death.
カタログ番号 | 製品名 / Synonyms | Species | Expression System |
---|---|---|---|
TMPY-04508 | IGFBP-7 Protein, Mouse, Recombinant (aa 1-281, hFc)
IGFBP-7 Protein, Mouse, Recombinant (aa 1-281, hFc)
|
Mouse | HEK293 |
Insulin-like growth factor-binding protein 7 (IGFBP7) is a member of the IGFBP family. It has been identified in colorectal adenocarcinoma (CRC) cell lines. The ... | |||
TMPY-00836 | IGFBP-4 Protein, Human, Recombinant (His)
IGFBP-4 Protein, Human, Recombinant (His)
|
Human | HEK293 |
Insulin-like growth factor-binding protein 4 (IGFBP-4) is a 24-kDa protein that binds insulin-like growth factor 1 (IGF-1) and IGF-2 with high affinity and inhib... | |||
TMPY-02533 | IGFBP-7 Protein, Human, Recombinant (aa 30-282, His)
IGFBP-7 Protein, Human, Recombinant (aa 30-282, His)
|
Human | HEK293 |
Insulin-like growth factor-binding protein 7 (IGFBP7) is a member of the IGFBP family. It has been identified in colorectal adenocarcinoma (CRC) cell lines. The ... | |||
TMPY-06982 | IGF1/IGF-I Protein, Human, Recombinant
IGF1/IGF-I Protein, Human, Recombinant
|
Human | E. coli |
IGF I, also known as Mechano Growth Factor, somatomedin-C, IGF-I, and IGF1, is a secreted protein that belongs to the insulin family. The insulin family, compris... | |||
TMPY-06982 | IGF1/IGF-I Protein, Human, Recombinant
IGF1/IGF-I Protein, Human, Recombinant
|
Human | E. coli |
IGF I, also known as Mechano Growth Factor, somatomedin-C, IGF-I, and IGF1, is a secreted protein that belongs to the insulin family. The insulin family, compris... | |||
TMPY-06982 | IGF1/IGF-I Protein, Human, Recombinant
IGF1/IGF-I Protein, Human, Recombinant
|
Human | E. coli |
IGF I, also known as Mechano Growth Factor, somatomedin-C, IGF-I, and IGF1, is a secreted protein that belongs to the insulin family. The insulin family, compris... | |||
TMPY-06982 | IGF1/IGF-I Protein, Human, Recombinant
IGF1/IGF-I Protein, Human, Recombinant
|
Human | E. coli |
IGF I, also known as Mechano Growth Factor, somatomedin-C, IGF-I, and IGF1, is a secreted protein that belongs to the insulin family. The insulin family, compris... | |||
TMPY-02295 | IGFBP-7 Protein, Human, Recombinant (aa 1-282, hFc)
IGFBP-7 Protein, Human, Recombinant (aa 1-282, hFc)
|
Human | HEK293 |
Insulin-like growth factor-binding protein 7 (IGFBP7) is a member of the IGFBP family. It has been identified in colorectal adenocarcinoma (CRC) cell lines. The ... | |||
TMPY-02118 | IGFBP-6 Protein, Mouse, Recombinant (His)
IGFBP-6 Protein, Mouse, Recombinant (His)
|
Mouse | HEK293 |
Insulin-like growth factor-binding protein 6 (IGFBP6) is a 24-kDa protein that binds insulin-like growth factor 1 (IGF-1) and IGF-2 with high affinity and inhibi... | |||
TMPY-00835 | IGFBP-3 Protein, Human, Recombinant (His)
IGFBP-3 Protein, Human, Recombinant (His)
|
Human | HEK293 |
The Insulin-like Growth Factor (IGF) signaling system plays a central role in cellular growth, differentiation, and proliferation. IGFBP3 is the most abundant IG... | |||
TMPY-05206 | IGFBP-5 Protein, Human, Recombinant (His)
IGFBP-5 Protein, Human, Recombinant (His)
|
Human | Baculovirus-Insect Cells |
IGFBP-5 Protein, Human, Recombinant (His) is expressed in Baculovirus-Insect Cells with His tag. The predicted molecular weight is 30 kDa. Accession number: P245... | |||
TMPY-06879 | IGFBP-7 Protein, Mouse, Recombinant (aa 26-281, His)
IGFBP-7 Protein, Mouse, Recombinant (aa 26-281, His)
|
Mouse | HEK293 |
Insulin-like growth factor-binding protein 7 (IGFBP7) is a member of the IGFBP family. It has been identified in colorectal adenocarcinoma (CRC) cell lines. The ... | |||
TMPY-06848 | IGFBP-7 Protein, Human, Recombinant (K95R, His)
IGFBP-7 Protein, Human, Recombinant (K95R, His)
|
Human | HEK293 |
Insulin-like growth factor-binding protein 7 (IGFBP7) is a member of the IGFBP family. It has been identified in colorectal adenocarcinoma (CRC) cell lines. The ... | |||
TMPY-06649 | IGFBP-7 Protein, Human, Recombinant (His & Avi), Biotinylated
IGFBP-7 Protein, Human, Recombinant (His & Avi), Biotinylated
|
Human | HEK293 |
Insulin-like growth factor-binding protein 7 (IGFBP7) is a member of the IGFBP family. It has been identified in colorectal adenocarcinoma (CRC) cell lines. The ... | |||
TMPY-06644 | IGFBP-7 Protein, Human, Recombinant (hFc & Avi), Biotinylated
IGFBP-7 Protein, Human, Recombinant (hFc & Avi), Biotinylated
|
Human | HEK293 |
Insulin-like growth factor-binding protein 7 (IGFBP7) is a member of the IGFBP family. It has been identified in colorectal adenocarcinoma (CRC) cell lines. The ... | |||
TMPY-04942 | IGF1 LR3 Protein, Human, Recombinant
IGF1 LR3 Protein, Human, Recombinant
|
Human | Yeast |
IGF I, also known as Mechano Growth Factor, somatomedin-C, IGF-I, and IGF1, is a secreted protein that belongs to the insulin family. The insulin family, compris... | |||
TMPY-04878 | IGF1/IGF-I Protein, Mouse, Recombinant
IGF1/IGF-I Protein, Mouse, Recombinant
|
Mouse | Yeast |
IGF I, also known as Mechano Growth Factor, somatomedin-C, IGF-I, and IGF1, is a secreted protein that belongs to the insulin family. The insulin family, compris... | |||
TMPY-04513 | IGFBP-6 Protein, Rat, Recombinant (His)
IGFBP-6 Protein, Rat, Recombinant (His)
|
Rat | HEK293 |
Insulin-like growth factor-binding protein 6 (IGFBP6) is a 24-kDa protein that binds insulin-like growth factor 1 (IGF-1) and IGF-2 with high affinity and inhibi... | |||
TMPY-04319 | IGFBP-2 Protein, Mouse, Recombinant (hFc)
IGFBP-2 Protein, Mouse, Recombinant (hFc)
|
Mouse | HEK293 |
IGFBP-2, also known as IGFBP2, is an insulin-like growth factor-binding protein (IGFBP). IGFBPs prolong the half-life of the IGFs, control bioavailability, activ... | |||
TMPY-04213 | IGFBP-2 Protein, Mouse, Recombinant (His)
IGFBP-2 Protein, Mouse, Recombinant (His)
|
Mouse | HEK293 |
IGFBP-2, also known as IGFBP2, is an insulin-like growth factor-binding protein (IGFBP). IGFBPs prolong the half-life of the IGFs, control bioavailability, activ... |