|
T21946 |
BIMU 8
|
|
5-HT Receptor
|
|
BIMU 8 is a selective agonist of 5-HT4 with EC50s of 18 nM, 77 nM, and 540 nM for wild-type 5HT4 receptor, T3.36A, and W6.48A mutant 5-HT4. |
|
TQ0311 |
GSK163090
|
|
Dopamine Receptor
,
5-HT Receptor
|
|
GSK163090 is a specific and orally active 5-HT1A/B/D receptor antagonist (pKis: 9.4/8.5/9.7, and 6.3/6.7 for 5-HT1A/B/D, and dopamine D2/D3). |
|
T16421 |
P-MPPI hydrochloride
|
|
5-HT Receptor
|
|
p-MPPI hydrochloride is a selective antagonist of 5-HT1A receptor, and has antidepressant and anxiolytic-like effects. |
|
T22453 |
Venlafaxine
|
Wy 45030 |
Serotonin Transporter
|
|
Venlafaxine (Wy 45030), an arylalkanolamine serotonin-norepinephrine reuptake inhibitor (SNRI), is used to treat major generalised anxiety disorder (GAD), depressive disorder (MDD), panic disorder and social phobia. |
|
T0162 |
Quetiapine
|
ICI204636,Quetiapin |
Dopamine Receptor
,
5-HT Receptor
,
Adrenergic Receptor
,
AChR
,
Histamine Receptor
|
|
Quetiapine (ICI204636) is used for the therapy of schizophrenia, and for the treatment of acute manic episodes associated with bipolar I disorder. The mechanism of quetiapine' action is thought by mediated through antago... |
|
T21013 |
Clomipramine
|
Chlorimipramine,Anafranil,Clomicalm,Anafranil (free base),Clomipramina |
5-HT Receptor
|
|
Clomipramine (Clomicalm) is a tricyclic antidepressant (TCA). It is used for the treatment of the panic disorder, obsessive-compulsive disorder, major depressive disorder, and chronic pain. It may decrease the risk of su... |
|
T0255 |
Clomipramine hydrochloride
|
Clomipramine HCl,Anafranil |
Dopamine Receptor
,
5-HT Receptor
,
Serotonin Transporter
,
Norepinephrine
,
GST
|
|
Clomipramine hydrochloride (Anafranil) is a tricyclic antidepressant similar to IMIPRAMINE that selectively inhibits the uptake of serotonin in the brain. It is readily absorbed from the gastrointestinal tract and demeth... |
|
T0137 |
Mirtazapine
|
6-Azamianserin,Org3770 |
Dopamine Receptor
,
5-HT Receptor
,
Opioid Receptor
,
Adrenergic Receptor
,
Histamine Receptor
|
|
Mirtazapine (6-Azamianserin) is a tetracyclic antidepressant with a somewhat unique mechanism of action. Mirtazapine therapy can be associated with transient asymptomatic elevations in serum aminotransferase levels and h... |
|
T6241 |
Quetiapine hemifumarate
|
Quetiapine Fumarate,ICI-204636 |
Dopamine Receptor
,
5-HT Receptor
,
Adrenergic Receptor
|
|
Quetiapine hemifumarate (ICI-204636), an atypical antipsychotic, is used in the treatment of bipolar I mania, schizophrenia, bipolar II depression, bipolar I depression. |
|
T26375 |
(S)-Amisulpride
|
Esamisulpride,(S) Amisulpride,SEP-4199 |
Dopamine Receptor
,
5-HT Receptor
|
|
(S)-Amisulpride ((S) Amisulpride) (Esamisulpride) is a potent dopamine D2/D3 receptor antagonist. (S)-Amisulpride is an antagonist at the 5-HT7 receptor with a Ki of 900 nM. (S)-Amisulpride has antipsychotic and antidepr... |
|
T1445 |
Agomelatine
|
Thymanax,S-20098,Valdoxan |
Melatonin Receptor
,
5-HT Receptor
|
|
Agomelatine (Valdoxan) is structurally closely related to melatonin. Agomelatine is a potent agonist at melatonin receptors and an antagonist at serotonin-2C (5-HT2C) receptors, tested in an animal model of depression. |
|
T0472 |
Venlafaxine hydrochloride
|
Venlafaxine HCl,Wy 45030 hydrochloride |
5-HT Receptor
,
Serotonin Transporter
|
|
Venlafaxine hydrochloride (Wy 45030 hydrochloride) is a cyclohexanol and phenylethylamine derivative that functions as a SEROTONIN AND NORADRENALINE REUPTAKE INHIBITOR (SNRI) and is used as an ANTIDEPRESSIVE AGENT. |
|
T4274 |
Melitracen hydrochloride
|
Thymeol hydrochloride,Melixeran |
Dopamine Receptor
,
5-HT Receptor
|
|
Melitracen hydrochloride (Thymeol hydrochloride) , an antidepressant, is used as potential dopamine D1/2 receptor antagonist to treat depression. |
|
T22051 |
BU 224 hydrochloride
|
|
Imidazoline Receptor
|
|
BU 224 hydrochloride is a selective imidazoline I(2) binding site ligand and has antinociceptive and antidepressant-like activities. |
|
T4297 |
Flibanserin
|
BIMT-17BS,Girosa,BIMT-17 |
Dopamine Receptor
,
5-HT Receptor
|
|
Flibanserin (Girosa) is a serotonergic antidepressant used to treat hypoactive sexual desire disorder. Flibanserin has been associated with a low rate of minor serum aminotransferase elevations during treatment but has n... |
|
T1483 |
Citalopram hydrobromide
|
Lu 10-171,Nitalapram HBr,Bonitrile HBr,XU-62-320,Lu 10-171 HBr,Citalopram HBr |
5-HT Receptor
,
Serotonin Transporter
,
Autophagy
|
|
Citalopram hydrobromide (XU-62-320) , a selective serotonin reuptake inhibitor (SSRI), selectively inhibits the CNS neuronal reuptake of serotonin, thereby potentiating serotonergic activity in the central nervous system... |
|
T3275 |
Nefazodone hydrochloride
|
Dutonin,MJ-13754-1,Serzone,BMY-13754-1,BMY-13754 |
5-HT Receptor
,
Adrenergic Receptor
|
|
Nefazodone hydrochloride (Serzone) is a serotoninergic modulating antidepressant that is used in therapy of depression, aggressive behavior and panic disorder. |
|
T68040 |
Cericlamine
|
|
5-HT Receptor
|
|
Cericlamine is a selective 5-hydroxytryptamine (5-HT) reuptake blocker with antidepressant activity. |
|
T60027 |
(+)-OSU 6162
|
Piperidine, 3-[3-(methylsulfonyl)phenyl]-1-propyl-, (3R)- |
5-HT Receptor
|
|
(+)-OSU 6162 (Piperidine, 3-[3-(methylsulfonyl)phenyl]-1-propyl-, (3R)-) is an agonist of 5-HT Receptor with anti-Alzheimer and antidepressant activities. |
|
T24444 |
Medifoxamine
|
LG 152,Medifoxamina,LG-152,LG152 |
Dopamine Receptor
,
Monoamine Oxidase
|
|
Medifoxamine (LG 152) is a selective non-monoamine oxidase inhibitor that exhibits antidepressant activity through inhibition of 5 HT reuptake.Medifoxamine preferentially inhibits dopamine reuptake. |
|
T0450 |
Fluoxetine
|
LY-110140 |
5-HT Receptor
,
Serotonin Transporter
,
MRP
,
Autophagy
|
|
Fluoxetine (LY-110140) is a highly specific serotonin uptake inhibitor and selective 5-hydroxytryptamine (5-HT) reuptake inhibitor. Fluoxetine has antidepressant activity. |
|
T37015 |
Iprindole
|
|
5-HT Receptor
|
|
Iprindole, a tricyclic indole antidepressant, is a dual weak inhibitor of noradrenaline and 5-HT uptake [1]. |
|
T22442 |
Trazodone
|
AF-1161 |
5-HT Receptor
|
|
Trazodone (AF-1161), a 5-HT 2A/2C receptor antagonist, is used as an antidepressant for treating major anxiety disorders and depressive disorder. |
|
T1279 |
Vilazodone
|
SB659746A,EMD 68843 |
5-HT Receptor
,
Serotonin Transporter
|
|
Vilazodone (SB659746A) is a selective serotonin (5-HT) reuptake inhibitor (SSRI) and a 5-HT-1A receptor partial agonist, with antidepressant and anti-anxiety activities. Vilazodone inhibits the reuptake of serotonin from... |
|
T62711 |
OPC-14523 hydrochloride
|
|
|
|
OPC-14523 hydrochloride is an orally active sigma and 5-HT1A receptor agonist with antidepressant-like activity. OPC-14523 shows a high affinity for the sigma receptor σ1/2 (IC50=47/56 nM), the 5-HT1A receptor (IC50=2.3 ... |
|
T68069 |
Femoxetine
|
|
MAO
,
5-HT Receptor
|
|
Femoxetine is a 5-HT inhibitor with antidepressant activity that potentiates morphine-induced anti-injury feelings and inhibits MAO-A and MAO-B required for the production of high exercise capacity in mice. |
|
T68162 |
Tiflucarbine
|
Tiflucarbina |
5-HT Receptor
,
PDE
|
|
Tiflucarbine is a potential non-selective 5-HT agonist with antidepressant activity.Tiflucarbine dose-dependently increased the specific activity of soluble calmodulin (CaM)-dependent phosphodiesterase in rat brain. |
|
T68141 |
Seganserin
|
|
5-HT Receptor
|
|
Seganserin, a non-selective 5-hydroxytryptamine 2-HT receptor antagonist, reversed the inhibitory effects of fluoxetine and quipazine on luteinizing hormone-induced hyperphagia, depression and nociception, and reversed t... |
|
T67956 |
Litoxetine
|
|
5-HT Receptor
|
|
Litoxetine is a selective 5-HT uptake inhibitor and is a 5-HT3 receptor antagonist. Litoxetine acts as an antidepressant and has shown antiemetic properties in ferrets. Litoxetine (1 and 10 mg/kg i.v.) dose-dependently r... |
|
T6188 |
Desvenlafaxine succinate hydrate
|
O-Desmethylvenlafaxine succinate hydrate,WY 45233 Succinate,Desvenlafaxine Succinate |
5-HT Receptor
,
Serotonin Transporter
,
Norepinephrine
|
|
Desvenlafaxine succinate hydrate (WY 45233 Succinate) is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI). |
|
T26137 |
RS 2232
|
RS-2232,RS2232 |
|
|
RS 2232 is an antidepressant found to be a competitive 5-HT inhibitor. |
|
T25248 |
Cianopramine
|
Ro 112465,Ro-112465,Ro112465 |
|
|
Cianopramine is a tricyclic antidepressant and a potent neuronal serotonin (5-HT) uptake inhibitor in animals. |
|
T30489 |
BMS 181101
|
BMS181101,BMS-181101 |
|
|
BMS-181101 is a novel antidepressant that has pharmacological characteristics as a serotonin reuptake inhibitor and a serotonin 5-HT receptor agonist. |
|
T13339 |
Wf-516
|
|
5-HT Receptor
|
|
Wf-516 is a 5-HT reuptake inhibitor (Kis: 5 nM and 40 nM for 5-HT1A receptor and 5-HT2A receptor in humans, respectively), and with potent antidepressant activity. |
|
T68793 |
Wy 25093
|
|
|
|
Wy 25093 is an inhibitor of the neuronal 5-hydroxytryptamine (5-HT) uptake process in vitro and in vivo, and may possess potential antidepressant activity. |
|
T68960 |
F-15599 Fumarate
|
|
|
|
F-15599 Fumarate is a highly selective post-synaptic 5-HT(1A) receptor agonist: in-vivo profile in behavioural models of antidepressant and serotonergic activity. |
|
T60508 |
(S)-Venlafaxine
|
|
|
|
(S)-Venlafaxine is the (S)-configuration of Venlafaxine which is an orally active, potent serotonin (5-HT)/norepinephrine (NE) reuptake dual inhibitor with antidepressant activity [1]. |
|
T12618 |
Quetiapine-d4 fumarate
|
Quetiapine D4 fumarate |
Others
|
|
Quetiapine D4 fumarate is the deuterium labeled Quetiapine fumarate. Quetiapine fumarate is a agonist of 5-HT receptors and a antagonist of dopamine receptor,with antidepressant and anxiolytic. |
|
T60607 |
Dasotraline
|
|
|
|
Dasotraline is a triple reuptake inhibitor that blocks dopamine(DA), norepinephrine(NE), and serotonin [5-hydroxytryptamine (5-HT)] transporters with IC 50 values of 4, 6, and 11 nM, respectively. Dasotraline represents ... |
|
T60576 |
Cyproheptadine
|
|
|
|
Cyproheptadine is a potent and orally active antagonist of the 5-HT 2A receptor. Cyproheptadine has antidepressant and antiserotonergic effects. Cyproheptadine also has antiplatelet and thromboprotective activities that ... |
|
T72220 |
DSP-1053 benzenesulfonate
|
|
|
|
DSP-1053, a benzylpiperidine derivative, is a potent inhibitor of the serotonin transporter (SERT) with a dissociation constant (K i) of 1.02 nM and exhibits partial agonistic activity at the 5-HT 1A receptor with a K i ... |
|
T70183 |
Eptapirone fumarate
|
|
|
|
Eptapirone, also known as F11440, is a potent 5HT(1A) receptor agonist with marked anxiolytic and antidepressant potential. The affinity of F 11440 for 5-HT1A binding sites (pKi, 8.33) was higher than that of buspirone (... |
|
T75944 |
Spadin TFA
|
|
|
|
Spadin TFA, a natural peptide originating from a propeptide in blood, acts as a powerful TREK-1 channel inhibitor with an IC 50 of 10 nM. It boosts dorsal raphe nucleus 5-HT neurotransmission in mice, activates hippocamp... |
|
T71302 |
Norfluoxetine-d5 HCl
|
|
|
|
Norfluoxetine-d5 is intended for use as an internal standard for the quantification of norfluoxetine by GC- or LC-MS. Norfluoxetine is an active metabolite of the antidepressant fluoxetine. It is formed from fluoxetine b... |
|
T70960 |
Maprotiline-d3 hydrochloride
|
|
|
|
Maprotiline-d3 is intended for use as an internal standard for the quantification of maprotiline by GC- or LC-MS. Maprotiline is a tricyclic antidepressant. It binds to the norepinephrine transporter (NET) and is selecti... |
|
T36521 |
Alaproclate (hydrochloride)
|
|
|
|
Alaproclate is a selective serotonin reuptake inhibitor (SSRI).1,2 It inhibits depletion of serotonin (5-HT) induced by 4-methyl-α-ethyl-m-tyramine in rat cerebral cortex, hippocampus, hypothalamus, and striatum (EC50s =... |
