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T10889 |
CRTh2 antagonist 2
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GPR
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CRTh2 antagonist 2 is a selective and potent CRTH2 antagonist, IC50≤10 nM. CRTh2 antagonist 2 can be used to study the direction of androgenic alopecia. |
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T10084 |
CRTh2 antagonist 1
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GPR
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CRTh2 antagonist 1 is a CRTh2 antagonist (IC50: 89 nM). |
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T10890 |
CRTh2 antagonist 3
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Others
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CRTh2 antagonist 3 is a powerful chemokine receptor homologous molecule expressed on Th2 cell (CRTh2) antagonists. CRTh2 antagonist 3 enhanced the activity of PDK1 on short peptide substrates with EC50 of 2 μM and Kd of ... |
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T10891 |
CRTH2-IN-1
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Ramatroban analog |
P450
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CRTH2-IN-1 is a selective prostaglandin D2 receptor DP2 (CRTH2) antagonist, a Ramatroban analog, with an IC50 of 6 nM in the human DP2 binding assay. |
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T17232 |
Vidupiprant
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AMG 853 |
Prostaglandin Receptor
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Vidupiprant (AMG 853) is an effective dual antagonist of CRTH2 and prostanoid D receptor with IC50s of 8 nM and 35 nM in human plasma. Vidupiprant can be used in studies about the treatment of asthma. |
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T14565 |
BI-671800
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AP-761,Cmpd A |
GPR
,
Prostaglandin Receptor
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BI-671800 (AP-761) is a highly specific and potent antagonist of chemoattractant receptor-homologous molecule on Th2 cells (DP2/CRTH2). With IC50 values of 4.5 nM and 3.7 nM for PGD2 binding to CRTH2 in hCRTH2 and mCRTH2... |
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T3520 |
Setipiprant
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KYTH-105,ACT-129968 |
GPR
,
Prostaglandin Receptor
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Setipiprant (ACT-129968) is an orally available, selective CRTH2 antagonist (IC50: 6.0 nM). CRTH2 is a G protein-coupled receptor for prostaglandin (PGD2). PGD2 is produced by the mast cells and is a key mediator in vari... |
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T10691 |
CAY10595
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GPR
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CAY10595 is an antagonist of the CRTh2 (DP2) receptor with a Ki of 10 nM. |
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T3965 |
Fevipiprant
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QAW039,NVP-QAW039 |
GPR
,
Prostaglandin Receptor
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Fevipiprant (NVP-QAW039) is a selective, potent, reversible competitive CRTh2 antagonist. |
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T7359 |
CAY10471 Racemate
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TM30089 Racemate |
GPR
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Prostaglandin Receptor
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CAY10471 Racemate (TM30089 Racemate) is a potent, highly selective CRTH2/DP 2 receptor antagonist. CAY10471 Racemate binds to the human CRTH2/DP2, DP1, and TP receptors( Ki values of 0.6, 1200, and >10,000 nM,respectivel... |
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T6399 |
AZD1981
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GPR
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Prostaglandin Receptor
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AZD1981 is an effective and specific CRTh2 (DP2) receptor antagonist (IC50: 4 nM), showing >1000-fold selectivity over more than 340 other enzymes and receptors, including DP1. AZD1981 has been used in trials studying th... |
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T77601 |
(2-{[2-(2-fluorophenoxy)ethyl]sulfanyl}-1H-benzimidazol-1-yl)acetic acid
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GPR
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(2-{[2-(2-fluorophenoxy)ethyl]sulfanyl}-1H-benzimidazol-1-yl)acetic acid is a prostaglandin-like CRTH2 antagonist with an IC50 < 10 μM, which can be used in studies of rhinitis, COPD, rheumatoid arthritis, eczema and con... |
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T2396 |
Ramatroban
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BAY u3405 |
GPR
,
Prostaglandin Receptor
,
PPAR
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Ramatroban (BAY u3405) (BAY u3405) is a thromboxane A(2) (TxA(2)) antagonist marketed for allergic rhinitis. It has been used in trials studying the treatment of Asthma. |
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T3306 |
PF-04418948
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PF 04418948,PF04418948 |
Prostaglandin Receptor
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PF-04418948 is a potent EP2 receptor antagonist (IC50 = 16 nM for human EP2 receptors). Displays over 2000-fold selectivity for EP2 receptors over EP1, EP3, EP4, DP1 amd CRTH2 receptors; exhibits <30% binding at a divers... |
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TQ0051 |
MK-7246
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GPR
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MK-7246 is a potent and specific CRTH2 antagonist (Ki: 2.5 nM). |
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T14211 |
AMG-009
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Others
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AMG-009 is a prostaglandin D2 antagonist. For CRTH2 and DP receptors, the IC50s are 3 nM and 12 nM, respectively. |
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T16097 |
MK-8318
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Others
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MK-8318 is an effective and selective antagonist of the CRTh2 receptor (Ki: 5.0 nM). |
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T15828 |
L 888607
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Others
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L 888607 is an effective and selective CRTH2 agonist (Ki: 0.8 nM). |
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T28925 |
TASP0376377
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TASP-0376377,TASP 0376377 |
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TASP0376377 is a potent antagonist of CRTH2. |
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T28927 |
TASP0412098
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TASP 0412098,TASP-0412098 |
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TASP0412098 is a potent, selective CRTH2 antagonist with oral activity. |
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T27799 |
LAS191859
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LAS-191859,LAS 191859 |
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LAS191859 is a CRTH2/DP2 antagonist with IC50 values of 7.6, 9.58, 14 and 15.5nM for recombinant guinea pig, human, rat and mouse CRTH2/DP2 receptors, respectively. LAS191859 has a residence time half-life of 21h at CRTh... |
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T28221 |
NVP-QAV-680
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NVP-QAV680,QAV690 free acid,NVP,QAV-690 free acid,NVPQAV680,QAV 690 free acid |
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NVP-QAV-680 is a potent and selective antagonist of CRTh2 receptor. NVP-QAV-680 has nM functional potency for inhibition of CRTh2 driven human eosinophil and Th2 lymphocyte activation in vitro. |
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T12067 |
MK-7246 S enantiomer
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Others
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MK-7246 S enantiomer is a potent and selective CRTH2 antagonist. |
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T71245 |
ARRY-502
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ARRY-502 is a CRTH2 antagonist. Regulation of cytokine activity is important in molecularly targeted therapies for asthma. |
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T38365 |
CAY10597
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The biological effects of prostaglandin D2 (PGD2) are transduced by at least two 7-transmembrane G protein-coupled receptors, designated DP1 and CRTH2/DP2. In humans, CRTH2/DP2 is expressed on Th2 cells, eosinophils, and... |
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T37328 |
Prostaglandin H1
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Prostaglandin H1 |
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Prostaglandin H1 is the cyclooxygenase metabolite of DGLA, a CRTh2 agonist and a precursor of a family of 1 anti-inflammatory prostaglandins. Prostaglandin H1 can be used in the study of inflammation. |
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T37264 |
15(R)-15-methyl Prostaglandin D2
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15(R)15methyl PGD2 |
GPR
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15(R)-15-methyl Prostaglandin D2 (15(R)15methyl PGD2) is a synthetic analogue of PGD2 and a selective and potent CRTH2/DP2 receptor agonist that modulates eosinophil CD11b expression, actin polymerisation and chemotaxis. |
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T36545 |
Prostaglandin D2 methyl ester
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Prostaglandin D2 methyl ester |
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Prostaglandin D2 (PGD2) is the major eicosanoid product of mast cells and is produced in large quantities by hematopoietic PGD synthase during allergic and asthmatic anaphylaxis. It causes vasodilation, flushing, hypoten... |
