|
T9499 |
Icenticaftor
|
QBW251 |
CFTR
|
|
Icenticaftor (QBW251) is an orally active potentiator of CFTR channel. |
|
T16681 |
Nesolicaftor
|
PTI-428 |
CFTR
,
Autophagy
|
|
Nesolicaftor (PTI-428) specifically enhances cystic fibrosis transmembrane conductance regulator protein synthesis. |
|
T14935 |
Elexacaftor
|
VX-445 |
CFTR
,
Autophagy
|
|
Elexacaftor (VX-445) is a modulator of cystic fibrosis transmembrane conductance regulator (CFTR) and it also facilitates the processing and trafficking of CFTR to increase the amount of CFTR at the cell surface. |
|
T3135 |
KM11060
|
|
CFTR
,
Autophagy
|
|
KM11060 is a novel corrector of the F508del-CFTR trafficking defect, Correcting F508del-CFTR trafficking, increasing the amount of functional CFTR at the plasma membrane. |
|
T1634 |
Glibenclamide
|
Glyburide |
Potassium Channel
,
Mitochondrial Metabolism
,
CFTR
,
P-gp
,
Autophagy
|
|
Glibenclamide (Glyburide) is an antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide. |
|
T1805 |
Ataluren
|
PTC124 |
CFTR
,
Autophagy
|
|
Ataluren (PTC124) is a novel, orally administered drug that targets nonsense mutations. Ataluren is approved for use by the European Medicines Agency to treat Duchenne Muscular Dystrophy in patients aged 5 years and olde... |
|
T5312 |
CFTR corrector 2
|
FDL169 |
CFTR
,
Autophagy
|
|
CFTR corrector 2 (FDL169) is a novel and potent CFTR (Cystic fibrosis transmembrane conductance regulator) corrector for treating cystic fibrosis (CF) patients who carry the F508del mutation. |
|
T2486 |
IOWH-032
|
IOWH032,IOWH 032 |
CFTR
,
Autophagy
|
|
IOWH-032 (IOWH032) , a synthetic CFTR inhibitor, has been investigated for the treatment of cholera, diarrhea, and secretory diarrhea. |
|
T2451 |
GlyH-101
|
GlyH 101 |
CFTR
,
Autophagy
|
|
GlyH-101 is a cell-permeable glycinyl hydrazone compound that blocks CFTR with Ki of 1.4 uM. |
|
T1874 |
PPQ-102
|
PPQ102,CFTR Inhibitor,PPQ 102 |
CFTR
,
Autophagy
|
|
PPQ-102 (CFTR Inhibitor), an effective CFTR inhibitor, can completely inhibit CFTR chloride current (IC50: 90 nM). |
|
T2588 |
Ivacaftor
|
Ivacaftor (VX-770),VX-770 |
CFTR
,
Autophagy
|
|
Ivacaftor (VX-770) (VX-770) is a potentiator of CFTR targeting G551D-CFTR (EC50: 100 nM) and F508del-CFTR (EC50: 25 nM) in Fisher rat thyroid cells, respectively. |
|
T7083 |
GLPG1837
|
ABBV-974 |
CFTR
,
Autophagy
|
|
GLPG1837 (ABBV-974) is an effective CFTR potentiator, with EC50s of 3 nM and 339 nM for F508del and G551D CFTR, respectively. |
|
T10591 |
BPO-27 racemate
|
BPO-27 (racemate) |
CFTR
,
Autophagy
|
|
|
|
T2595 |
Lumacaftor
|
VX-809,VRT 826809 |
CFTR
,
Autophagy
|
|
Lumacaftor (VRT 826809) is a CFTR modulator that corrects the folding and trafficking of CFTR protein. It enhances F508del-CFTR protein maturation in FRT cells (EC50: 100 nM). |
|
T2355 |
CFTR(inh)-172
|
CFTRinh 172,CFTR Inhibitor-172,CFTRinh-172,CFTRinh172 |
CFTR
,
Autophagy
|
|
CFTR(inh)-172 (CFTR Inhibitor-172) is a voltage-independent, selective CFTR inhibitor. |
|
T2263 |
Tezacaftor
|
VX661 |
CFTR
,
Autophagy
|
|
Tezacaftor (VX661) is a small molecule that can be used as a corrector of the cystic fibrosis transmembrane conductance regulator (CFTR) gene function. |
|
T20341 |
DNDS
|
|
CFTR
|
|
DNDS is a channel blocker of voltage-dependent cystic fibrosis transmembrane conductance regulator (CFTR). |
|
T63806 |
CFTR corrector 8
|
|
CFTR
|
|
CFTR corrector 8 is a highly effective modulator of the cystic fibrosis transmembrane conductance regulator (CFTR). This compound is specifically designed for utilization in research related to cystic fibrosis, a genetic... |
|
T26955 |
Cavosonstat
|
N91115,N 91115,N-91115 |
GSNOR
,
CFTR
|
|
Cavosonstat (N91115) is an orally active S-nitrosoglutathione reductase (GSNOR) inhibitor that promotes cystic fibrosis transmembrane conductance regulator (CFTR) maturation and plasma membrane stabilization.Cavosonstat ... |
|
T60653 |
CFTR corrector 9
|
|
CFTR
|
|
CFTR Corrector 9, a cystic fibrosis transmembrane conductance regulator (CFTR) modulator, is employed in the research of cystic fibrosis (CF) and related CFTR-associated disorders [1]. |
|
T10776 |
CFTR corrector 4
|
|
CFTR
|
|
CFTR corrector 4 is a potent and orally available transmembrane conductance regulator (CFTR) for cystic fibrosis and is a potent (R,R) type active enantiomer. CFTR corrector 4 increases CFTR levels on the cell surface a... |
|
T29040 |
UCCF-029
|
UC(CF)-029,UC(CF) 029,UCCF029,UC(CF)029 |
|
|
UCCF-029 is an activator of cystic fibrosis transmembrane conductance regulator (CFTR). |
|
T23648 |
AF-2785
|
|
|
|
In epididymal epithelial cells, AF-2785 inhibits cystic fibrosis transmembrane conductance regulator Cl(-) channels. |
|
T13705 |
GLPG2451
|
|
Cysteine Protease
|
|
GLPG2451 is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator. It effectively potentiates low temperature rescued F508del CFTR (EC50: 11.1 nM). |
|
T74417 |
Vanzacaftor
|
|
|
|
Vanzacaftor is a cystic fibrosis transmembrane conductance regulator (CFTR) modulator researched for cystic fibrosis treatment. |
|
T13704 |
GLPG-3221
|
|
Others
|
|
GLPG-3221 can be uesd for the treatment of cystic fibrosis.GLPG-3221 is a potent, orally active corrector of CFTR (cystic fibrosis transmembrane conductance regulator), with an EC50 of 105 nM. |
|
T72860 |
(R)-Olacaftor
|
(R)-VX-440 |
Others
|
|
(R)-Olacaftor ((R)-VX-440), a Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) modulator, shows promising potential in cystic fibrosis (CF) research. |
|
T84699 |
(R)-Vanzacaftor
|
|
|
|
(R)-Vanzacaftor ((R)-VX-121) is a cystic fibrosis transmembrane conductance regulator (CFTR) modulator [1]. |
|
T37686 |
CFTR corrector 6
|
|
|
|
CFTR corrector 6 is a highly effective CFTR potentiator utilized in research on cystic fibrosis (CF) and related CFTR-associated disorders[1]. This potent compound exhibits potentiation activity on the Cystic Fibrosis Tr... |
|
T61306 |
SRI-41315
|
|
Others
|
|
SRI-41315, a chemical compound, effectively addresses premature termination codons (PTCs) associated with cystic fibrosis in immortalized and primary human bronchial epithelial cells. It induces a prolonged pause at stop... |
|
T78240 |
(R)-Elexacaftor
|
(R)-VX-445 |
CFTR
|
|
(R)-Elexacaftor, an enantiomer of Elexacaftor, functions as a modulator of the cystic fibrosis transmembrane conductance regulator (CFTR). It exhibits an EC50 of 0.29 µM for the CFTR dF508 mutation [1]. |
|
T37564 |
C4 Ceramide (d18:1/4:0)
|
C4 Ceramide (d18:1/4:0),Cer(d18:1/4:0) |
Others
|
|
C4 Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides. [1] [2] [3] It inhibits IL-4 production by 16% in EL4 T cells stimulated with phorbol 12-myristate 13-acetate when used... |
|
T37756 |
Phloxine B
|
|
|
|
Phloxine B is a red dye, the USP grade of which is used as a color additive for food, drugs, and cosmetics. It has also been used as an alternative to Gram staining, to differentiate between Gram-negative and Gram-positi... |
