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T35992 |
Ent-Prostaglandin F2α
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ent-Prostaglandin F2α |
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ent-Prostaglandin F2α is the enantiomer of PGF2α and is found in urine. |
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T36455 |
11β-Prostaglandin F2α
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11β-Prostaglandin F2α |
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11β-Prostaglandin F2α is a bioactive metabolite catalyzed by AKR1C3 that stimulates prostaglandin F receptors and induces slug expression in breast cancer. 11β-Prostaglandin F2α is also an endogenous metabolite present i... |
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T38195 |
Prostaglandin F2α Ethanolamide
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Prostaglandin F2α Ethanolamide |
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Prostaglandin F2α ethanolamide (PGF2α-EA) is produced by COX-2 metabolism of the endogenous cannabinoid, arachidonoyl ethanolamide (AEA), found in brain, liver, and other mammalian tissues. AEA can be metabolized directl... |
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T37840 |
20-hydroxy Prostaglandin F2α
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20-hydroxy Prostaglandin F2α |
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20-hydroxy Prostaglandin F2α (20-hydroxy PGF2α) is the ω-oxidation product of PGF2α. Cultured type II alveolar cells from pregnant rabbits metabolize exogenous PGF2α via microsomal cytochrome P450 ω-oxidation, producing ... |
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T37993 |
16,16-dimethyl Prostaglandin F2α
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16,16-dimethyl Prostaglandin F2α |
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16,16-dimethyl Prostaglandin F2α can be used in related research in the field of life sciences. Its product number is T37993 and CAS number is 39746-23-1. |
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T37327 |
Prostaglandin F2α 1,15-lactone
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Prostaglandin F2α 1,15-lactone |
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PGF2α 1,15-lactone is a lipid-soluble internal ester of PGF2α. Hydrolysis of the lactone readily produces free PGF2α in plasma. In rhesus monkeys, a total dose of 15 mg of PGF2α 1,15-lactone terminates early pregnancy, w... |
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T38196 |
Prostaglandin F2α isopropyl ester
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Prostaglandin F2α isopropyl ester |
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PGF2α isopropyl ester is an ester prodrug of PGF2α with enhanced lipid solubility. Due to better membrane penetration, PGF2α isopropyl ester is more suitable than PGF2α or PGF2α tromethamine salt for topical application ... |
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T37275 |
2,3-dinor-11β-Prostaglandin F2α
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2,3-dinor-11β-Prostaglandin F2α |
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2,3-dinor-11β-Prostaglandin F2α (2,3-dinor-11β-PGF2α) was recovered from the urine of both normal monkeys and humans when infused with radiolabeled PGD2, where it represented approximately 1% and 4% of the infused radiol... |
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T37995 |
16-phenoxy tetranor Prostaglandin F2α
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16-phenoxy tetranor Prostaglandin F2α |
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16-phenoxy PGF2α is a metabolically stable analog of PGF2α. It binds to the FP receptor on ovine luteal cells with much greater affinity (440%) than PGF2α. |
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T37946 |
17-trifluoromethylphenyl trinor Prostaglandin F2α
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17-trifluoromethylphenyl trinor Prostaglandin F2α |
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A number of 17-phenyl trinor prostaglandin F2α (17-phenyl trinor PGF2α) derivatives have been approved for the treatment of glaucoma. Of these, the unsubstituted or meta-substituted aromatic derivatives are the most pote... |
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T36146 |
13,14-dihydro Prostaglandin F2α
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13,14-dihydro Prostaglandin F2α,13,14-dihydro PGF2α |
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13,14-dihydro Prostaglandin F2α (13,14-dihydro PGF2α) is the analog of PGF2α which has no unsaturation in the lower side chain. It causes luteolysis in hamsters with a potency five times higher than PGF2α. The ED50 value... |
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T36617 |
Ent-8-iso Prostaglandin F2α
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ent-8-iso Prostaglandin F2α |
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ent-8-iso Prostaglandin F2α is a potent vasoconstrictor of porcine retinal and cerebral microvessels with EC50 values of 30.6 and 53.5 nM, respectively. |
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T37991 |
15-keto Prostaglandin F2α
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15-keto Prostaglandin F2α,15-keto PGF2α |
Endogenous Metabolite
,
Prostaglandin Receptor
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15-keto Prostaglandin F2α is a metabolite of Prostaglandin F2α that lowers intraocular pressure in rabbits. |
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T36166 |
8-iso-15-keto Prostaglandin F2α
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8-iso-15-keto Prostaglandin F2α |
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8-iso-15-keto Prostaglandin F2α (8-iso-15-keto PGF2α) is a metabolite of the isoprostane 8-iso PGF2α in rabbits, monkeys, and humans. 8-isoprostane (8-iso PGF2α) is a prostaglandin-like product of non-specific lipid pero... |
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T37326 |
Prostaglandin F2α 1,11-lactone
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Prostaglandin F2α 1,11-lactone,PGF2α 1,11-lactone |
Prostaglandin Receptor
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Prostaglandin F2α 1,11-lactone (PGF2α 1,11-lactone) is a lipid-soluble prodrug of Prostaglandin F2α and can be used in studies about treating glaucoma. Prostaglandin F2α 1,11-lactone is active as an antifertility agent w... |
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T37948 |
17-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F2α
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17-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F2α |
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A number of 17-phenyl trinor prostaglandin F2α(17-phenyl trinor PGF2α) derivatives have been approved for the treatment of glaucoma.1,2,3Of these, the ones wherein the 13,14-double bond has been hydrogenated retain relat... |
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T37936 |
16-phenoxy tetranor Prostaglandin F2α isopropyl ester
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16-phenoxy tetranor Prostaglandin F2α isopropyl ester |
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Prostaglandin F2α (PGF2α) drives luteolysis and smooth muscle contraction by activating the FP receptor. Stable, lipophilic analogs of PGF2α are used to modulate luteolysis and treat glaucoma. 16-phenoxy tetranor Prostag... |
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T37940 |
17-phenyl trinor Prostaglandin F2α cyclopropyl amide
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17-phenyl trinor Prostaglandin F2α cyclopropyl amide |
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17-phenyl trinor Prostaglandin F2α cyclopropyl amide (17-phenyl trinor PGF2α cyclopropyl amide) is a novel analog of 17-phenyl trinor PGF2α ethyl amide. There are no published reports on the biological activity of 17-phe... |
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T37777 |
17-trifluoromethylphenyl trinor Prostaglandin F2α ethyl amide
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17-trifluoromethylphenyl trinor Prostaglandin F2α ethyl amide |
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Prostaglandin F2α (PGF2α), acting through the FP receptor, causes smooth muscle contraction and exhibits potent luteolytic activity. 17-trifluoromethylphenyl trinor Prostaglandin F2α (17-trifluoromethylphenyl trinor PGF2... |
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T37937 |
16-phenoxy tetranor Prostaglandin F2α methyl ester
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16-phenoxy tetranor Prostaglandin F2α methyl ester |
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Prostaglandin F2α (PGF2α) drives luteolysis and smooth muscle contraction by activating the FP receptor. Stable, lipophilic analogs of PGF2α are used to modulate luteolysis and treat glaucoma. 16-phenoxy tetranor Prostag... |
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T37947 |
17-trifluoromethylphenyl trinor Prostaglandin F2α methyl ester
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17-trifluoromethylphenyl trinor Prostaglandin F2α methyl ester |
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Prostaglandin F2α (PGF2α), acting through the FP receptor, causes smooth muscle contraction and exhibits potent luteolytic activity. 17-trifluoromethylphenyl trinor PGF2α is an analog of PGF2α that shares the meta-triflu... |
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T37944 |
17-phenyl trinor Prostaglandin F2α methyl amide
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17-phenyl trinor Prostaglandin F2α methyl amide |
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17-phenyl trinor Prostaglandin F2α (17-phenyl trinor PGF2α) is a metabolically stable analog of PGF2α and is a potent agonist for the FP receptor, binding with a relative potency of 756% compared to that of PGF2α. The et... |
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T37938 |
17-phenoxy trinor Prostaglandin F2α ethyl amide
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17-phenoxy trinor Prostaglandin F2α ethyl amide |
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Prostaglandin F2α (PGF2α), acting through the FP receptor, causes smooth muscle contraction and exhibits potent luteolytic activity. Both 17-phenyl trinor PGF2α and 16-phenoxy tetranor PGF2α are metabolically stable anal... |
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T37942 |
17-phenyl trinor Prostaglandin F2α dimethyl amide
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17-phenyl trinor Prostaglandin F2α dimethyl amide |
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17-phenyl trinor Prostaglandin F2αdimethyl amide is an isomer of 17-phenyl trinor prostaglandin F2αethyl amide .
N/A |
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T37930 |
15(R)-17-phenyl trinor Prostaglandin F2α
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15(R)-17-phenyl trinor Prostaglandin F2α |
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17-phenyl trinor Prostaglandin F2α N-ethyl amide (17-phenyl trinor PGF2α) is an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug, sold under the Allergan trade name 17-phenyl tr... |
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T37943 |
17-phenyl trinor Prostaglandin F2α isopropyl ester
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17-phenyl trinor Prostaglandin F2α isopropyl ester |
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17-phenyl trinor PGF2α N-ethyl amide is an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug, sold under the Allergan trade name Bimatoprost. The N-ethyl amide prostaglandin prod... |
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T35990 |
Ent-8-iso-15(S)-Prostaglandin F2α
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ent-8-iso-15(S)-Prostaglandin F2α |
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Isoprostanes are produced by the non-enzymatic, free radical peroxidation of phospholipid-esterified arachidonic acid. They have been used as biomarkers of oxidative stress, but they also have been found to have potent b... |
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T37934 |
15-keto-17-phenyl trinor Prostaglandin F2α
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15-keto-17-phenyl trinor Prostaglandin F2α |
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Bimatoprost is an F-series prostaglandin (PG) analog which has been approved for use as an ocular hypotensive drug. Oxidation of the C-15 hydroxyl group and amide hydrolysis of Bimatoprost produces 15-keto-17-phenyl trin... |
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T38197 |
Prostaglandin F2α Alcohol
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Prostaglandin F2α Alcohol is a PGF2α (T15133) analogue. Prostaglandin F2α Alcohol is an orally active prostaglandin F receptor (FP receptor) agonist. |
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T37935 |
16-phenoxy tetranor Prostaglandin F2α cyclopropyl methyl amide
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16-phenoxy tetranor Prostaglandin F2α cyclopropyl methyl amide |
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The actions of many clinical F-series prostaglandins (PGs), including those used for estrous synchronization and for reduction of intraocular pressure (IOP), are mediated through the PGF2α (FP) receptor. 16-phenoxy tetra... |
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T37941 |
17-phenyl trinor Prostaglandin F2α cyclopropyl methyl amide
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17-phenyl trinor Prostaglandin F2α cyclopropyl methyl amide |
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Prostaglandin F2α (PGF2α) activates the FP receptor, promoting smooth muscle contraction and luteolysis. 17-phenyl trinor PGF2α binds the FP receptor on ovine luteal cells with a relative potency of 756% compared to that... |
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T36156 |
15(S)-15-methyl Prostaglandin F2α methyl ester
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15(S)-15-methyl Prostaglandin F2α methyl ester |
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15(S)-15-methyl Prostaglandin F2α methyl ester can be used in related research in the field of life sciences. Its product number is T36156 and CAS number is 35700-21-1. |
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T36155 |
15(S)-15-methyl Prostaglandin F2α isopropyl ester
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15(S)-15-methyl Prostaglandin F2α isopropyl ester |
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15(S)-15-methyl Prostaglandin F2α (15(S)-15-methyl PGF2α) has been shown to have potent uterine stimulant and abortifacient properties when administered intramuscularly to induce labor. 15(S)-15-methyl PGF2α isopropyl es... |
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T36165 |
8-iso-13,14-dihydro-15-keto Prostaglandin F2α
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8-iso-13,14-dihydro-15-keto Prostaglandin F2α |
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8-iso-13,14-dihydro-15-keto Prostaglandin F2α (8-iso-13,14-dihydro-15-keto PGF2α) is a metabolite of the isoprostane, 8-isoprostane (8-iso PGF2α), in rabbits, monkeys and humans. 8-iso PGF2α is a PG-like product of non-s... |
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T35944 |
15-keto-17-phenyl trinor Prostaglandin F2α ethyl amide
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15-keto-17-phenyl trinor Prostaglandin F2α ethyl amide |
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Bimatoprost is the Allergan trade name for 17-phenyl trinor prostaglandin F2α ethyl amide (17-phenyl trinor PGF2α ethyl amide), an F-series PG analog which has been approved for use as an ocular hypotensive drug. Oxidati... |
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T38198 |
Prostaglandin F2α methyl ester
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Prostaglandin F2α methyl ester is a highly lipid-soluble PGF2α analog used to maintain low intraocular pressure. |
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T22285 |
Carboprost
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15(S)-15-Methyl Prostaglandin F2α,15-Methyl-PGF2α |
Prostaglandin Receptor
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Carboprost (15(S)-15-Methyl Prostaglandin F2α) is a synthetic prostaglandin analogue of PGF2α which has the effect of oxytocic. Carboprost is commonly used to restore uterine tone. |
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T4546 |
Dinoprost tromethamine salt
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Dinoprost Tromethamine,Zinoprost,Prostin F2 alpha,PGF2α THAM,Dinolytic,Prostaglandin F2α THAM |
Apoptosis
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Endogenous Metabolite
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Prostaglandin Receptor
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Autophagy
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PROTAC Linker
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Dinoprost tromethamine salt (PGF2α THAM) is a naturally occurring prostaglandin used in medicine to induce labor and as an abortifacient. |
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T37939 |
N-Desethyl Bimatoprost
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17-phenyl trinor Prostaglandin F2α amide |
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N-Desethyl Bimatoprost (17-phenyl trinor PGF2α amide) is an F-series PG analog in which the C-1 carboxyl group has been modified to an unsubstituted amide. PG esters have been shown to have ocular hypotensive activity. P... |
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T37945 |
Bimatoprost methyl ester
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17-phenyl trinor Prostaglandin F2α methyl ester |
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Prostaglandin F2α (PGF2α) drives luteolysis and smooth muscle contraction by activating the FP receptor. Bimatoprost methyl ester is a lipophilic analog of 17-phenyl trinor PGF2α, a potent agonist for the FP receptor. 17... |
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T36908 |
Bimatoprost grenod
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15-(6-nitroxyhexanoyl)-17-phenyl trinor Prostaglandin F2α |
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Bimatoprost grenod(15-(6-nitroxyhexanoyl)-17-phenyl trinor PGF2α) is a nitric oxide-donating derivative of 17-phenyl trinor PGF2α.1It increases cGMP levels in rabbit aqueous humor and iris ciliary body when topically adm... |
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T29725 |
AGN-191129
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AGN191129,Prostaglandin F2α alcohol methyl ether,PGF2α-OMe,UNII-NK1168QB5T |
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AGN-191129, also known as Prostaglandin F2α alcohol methyl ether (PGF2α-OMe), is an analog of PGF2α in which the C-1 carboxyl group has been replaced by an O-methyl ether. The compound is reported to retain ocular hypote... |
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T29246 |
Cloprostenol isopropyl ester
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(+)-16-m-chlorophenoxy tetranor Prostaglandin F2α isopropyl ester,(+)-Cloprostenol isopropyl ester |
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Cloprostenol isopropyl ester is a PGF2α agonist and a similar synthetic prostaglandin F2α (PGF2α), which can induce luteal dissolution in mares during the luteal phase without causing clinical side effects or stress resp... |
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T36605 |
(±)5-iPF2α-VI
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(±)5-iPF2α-VI |
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Isoprostanes are prostaglandin (PG)-like products of free-radical induced lipid peroxidation. Although the isoprostanes derived from arachidonic acid are the best characterized, many other polyunsaturated fatty acids can... |
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T62637 |
EIF2α activator 2
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EIF2α activator 2 (Compound 1) is a phosphorylated activator of eukaryotic initiation factor 2α (eIF2α). EIF2α activator 2 is anti-proliferative in K562 cells (IC50: 4.79 μM) and PBMC cells (IC50: 10.52 μM). |
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T63665 |
EIF2α activator 1
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EIF2α Activator 1 (Compound 40) is a chemical compound that activates the phosphorylation of eukaryotic initiation factor 2 alpha (eIF2α), enhancing the expression of downstream proteins ATF and CHOP. It demonstrates ant... |
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T21224 |
(+)-Fluprostenol
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Fluprostenol, (+)-,Travoprost acid,AL-5848 |
Prostaglandin Receptor
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(+)-Fluprostenol (AL-5848), an analogue of prostaglandin F2 alpha, is a prostaglandin F2α receptor PTGFR agonist and decreases the expression of Oviductal glycoprotein 1 (OVGP1). |
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T12285 |
Ebopiprant
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OBE022,OBE-022 |
Others
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T5847 |
Cloprostenol sodium salt
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ICI 80996 sodium salt,DL-Cloprostenol sodium,Cloprostenol sodium |
Prostaglandin Receptor
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Cloprostenol sodium salt (ICI 80996 sodium salt) is a more water solute, crystalline form of cloprostenol than the free acid, is a synthetic analog of prostaglandin F2α. |
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T2528 |
Latanoprost
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Xalatan,PHXA41 |
GPR
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Prostaglandin Receptor
,
RAR/RXR
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Latanoprost (Xalatan) is a prostaglandin F2alpha analogue and a prostanoid selective FP receptor agonist with an ocular hypertensive effect. |
