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カタログ番号 | 製品名 | 別名 | ターゲット |
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T11186 | EMPA | OX Receptor | |
EMPA is a selective, high-affinity and reversible antagonist of orexin OX2 receptor(human and rat OX2-HEK293 membranes with KD values of 1.1 and 1.4 nM respectively) | |||
T5503 | IPSU | OX Receptor | |
IPSU is an antagonist of OX2 receptor. IPSU Exhibits approximately six-fold selectivity for OX2 versus OX1 receptors. | |||
T2710 | TCS 1102 | DORA-1 | OX Receptor |
TCS 1102 is an effective, dual orexin receptor antagonist (Ki: 0.2/3 nM for OX2/1 receptors). | |||
T3177 | Orexin 2 Receptor Agonist | OX2R | OX Receptor |
Orexin 2 Receptor Agonist (OX2R) is an effective (EC50: 23 nM) and OX2R-selective (OX1R/OX2R EC50 ratio: 70) agonist. | |||
T1913 | MK-3697 | OX Receptor | |
MK-3697, an isonicotinamide small molecule, acts as a potent and selective Orexin 2 receptor antagonist (Ki: 0.95 nM). | |||
T4965 | TCS-OX2-29 | OX Receptor | |
TCS-OX2-29 is a potent and selective OX2 receptor antagonist (IC50: 40 nM). It displays >250-fold selectivity for OX2 over OX1. | |||
T16096 | Filorexant | MK-6096 | OX Receptor |
Filorexant (MK-6096) is an orally bioavailable effective and selective reversible antagonist of OX1 and OX2 receptor with (Ki <3 nM). | |||
T2613 | Almorexant | ACT 078573 | OX Receptor |
Almorexant (ACT 078573) is a potent and competitive dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist with Ki values of 1.3 and 0.17 nM for OX1 and OX2, respectively. | |||
T12877L | Seltorexant | JNJ-42847922 | OX Receptor |
Seltorexant (JNJ-42847922) crosses the blood-brain barrier and quickly occupies OX2R binding sites in the rat brain. Seltorexant is a high-affinity and selective orexin-2 receptor antagonist (pKi: 8.0 and 8.1 for human a... | |||
T5498 | SB-649868 | GSK649868 | OX Receptor |
SB-649868 (GSK649868) is a potent and selective orally active antagonist of orexin(pKi =9.4 and 9.5 at the OX1 and OX2 receptor, respectively). | |||
T3722 | MK-1064 | Urokinase inhibitor 1,MK 1064 | OX Receptor |
MK-1064 (Urokinase inhibitor 1) is a selective orexin 2 receptor antagonist (2-SORA). | |||
T6658 | SB-408124 | OX Receptor | |
SB408124 is a non-peptide antagonist for OX1 receptor with Ki of 57 nM and 27 nM in both whole cell and membrane, respectively, exhibits 50-fold selectivity over OX2 receptor. | |||
T6140 | SB-334867 free base | SB334867A free base,SB-334867,SB 334867,SB334867 | OX Receptor |
SB-334867 free base (SB334867A free base) is a selective orexin-1 (OX1) receptor antagonist. | |||
T6155 | Almorexant hydrochloride | ACT-078573 hydrochloride,Almorexant HCl | OX Receptor |
Almorexant hydrochloride (ACT-078573 hydrochloride) is a potent and competitive dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist with Ki values of 1.3 and 0.17 nM for OX1 and OX2, respectively. | |||
T76437 | Hypocretin (70-98), human | ||
Hypocretin (70-98), human, is a polypeptide that binds to the orexin receptor OX1R and facilitates apoptosis [1]. |
カタログ番号 | 製品名 | Species | Expression System |
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TMPH-01816 | OX1R Protein, Human, Recombinant (His & SUMOstar) | Human | P. pastoris (Yeast) |
Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Triggers an increase in cytoplasmic Ca(2+) levels in response to orexin-A binding. OX1R Protein, Human, Recombi... |