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T5491 |
GSK3179106
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c-RET
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GSK3179106 is RET kinase inhibitor with an IC50 of 0.4 nM |
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T1460 |
Dicyclomine hydrochloride
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AChR
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Dicyclomine hydrochloride is a muscarinic antagonist used as an antispasmodic and in urinary incontinence. |
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T40481 |
IBS008738
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IBS008738, a potent TAZ activator, stabilizes TAZ, elevates the unphosphorylated TAZ level, enhances the interaction of MyoD with the myogenin promoter, upregulates gene transcription regulated by MyoD, and competes with... |
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T1006 |
Propantheline bromide
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Neopepulsan,Pro-Banthine,Neometantyl |
AChR
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Propantheline bromide (Pro-Banthine) competitively antagonizes acetylcholine activity mediated by muscarinic receptors at neuroeffector sites on smooth muscle and exocrine gland cells. Propantheline Bromide is the bromid... |
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T1551 |
Tegaserod maleate
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HTF-919,SDZ-HTF-919 |
5-HT Receptor
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Tegaserod maleate (SDZ-HTF-919) is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. Its use was the only drug approved by the United States Food and Drug ... |
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T3178 |
BIBS 39
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RAAS
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BIBS 39 is a new nonpeptide angiotensin II (AII) receptor antagonist. |
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T26802 |
BIBS-222
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BIBS 222 |
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BIBS-222, a nonpeptide angiotensin II (Ang II) receptor antagonist, appears to be an effective antihypertensive in the model of the renal hypertensive rat. |
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T11852 |
リナクロチド
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Guanylate cyclase
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Linaclotide developed for the treatment of constipation-predominant irritable bowel syndrome (IBS-C) and chronic constipation, and is a potent and selective guanylate cyclase C agonist. |
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T60680 |
Tegaserod
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5-HT Receptor
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Tegaserod is an orally available 5-HT4R agonist and 5-HT2B receptor antagonist with inhibitory effects on various 5-hydroxytryptamine receptors. Tegaserod has antitumor activity and is used in the treatment of irritable ... |
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T38507 |
Renzapride
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BRL 24924 |
5-HT Receptor
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Renzapride (BRL 24924) is a mixed 5-hydroxytryptamine type 4 (5-HT4) agonist and 5-HT3 receptor antagonist.Renzapride can be used in the study of constipation-predominant irritable bowel syndrome (C-IBS). |
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T0918 |
Trimebutine
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Mebutin |
Opioid Receptor
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Trimebutine (Mebutin) is a spasmolytic agent that regulates intestinal and colonic motility and relieves abdominal pain with antimuscarinic and weak mu-opioid agonist effects. It is marketed for the treatment of irritabl... |
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T13002 |
SSR-241586
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Others
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SSR-241586 is a neurokinin receptors antagonist,and is shown to be active in the treatment of depression, schizophrenia, urinary trouble, emesis, and irritable bowel syndrome (IBS). |
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T21235 |
Alosetron
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Lotronex,GR68755,GR-68755,GR 68755 |
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Alosetron, a 5-HT3 antagonist, is used for the management of severe diarrhea-predominant irritable bowel syndrome (IBS) in women only. |
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T24887 |
Tiropramide
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CR-605 |
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Tiropramide is an antispasmodic drug. It also useful to inhibit the contractile response of the urinary bladder and in managing abdominal pain in IBS. |
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T38482 |
MM 419447
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|
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MM 419447 is a guanylate cyclase-C agonist, and it is a metabolite of linaclotide. This compound, MM 419447, shows promise in the field of irritable bowel syndrome with constipation (IBS-C) research. |
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T30936 |
Cilansetron Hydrochloride
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KC-9946,KC9946,KC 9946 |
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Cilansetron Hydrochloride can be used for irritable Bowel Syndrome (IBS) with Diarrhea Predominance. |
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T4633 |
Asimadoline
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EMD-61753 |
Opioid Receptor
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Asimadoline (EMD-61753) is a proprietary small molecule therapeutic, originally discovered by Merck KGaA of Darmstadt, Germany. Asimadoline was originally developed to treat peripheral pain such as arthritis. Asimadoline... |
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T63877 |
RET-IN-17
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|
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RET-IN-17 is a potent inhibitor of RET. RET-IN-17 has potential for studies of pain associated with IBS and other gastrointestinal disorders, as well as cancers with constitutive RET kinase activity. |
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T64234 |
Alosetron (Hydrochloride(1:X))
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|
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Alosetron (GR 68755) Hydrochloride (1:X) is a potent and highly selective 5-HT3 receptor antagonist with anti-inflammatory effects. Alosetron Hydrochloride (1:X) can be used in the study of irritable bowel syndrome (IBS)... |
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T72809 |
(S)-Renzapride
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(S)-BRL 24924 |
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(S)-Renzapride ((S)-BRL 24924), an isomer of Renzapride, acts as a 5-HT4 receptor agonist with a K_i value of 115 nM and also antagonizes 5HT2b and 5HT3 receptors. It is utilized in studies focused on constipation-predom... |
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T78084 |
PSB 0777 ammonium hydrate
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Adenosine Receptor
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PSB 0777 ammonium hydrate is a potent and selective adenosine A2A receptor full agonist, exhibiting K i values of 44.4 nM for rat A2A receptors and 360 nM for human A2A receptors. For rat and human A1 receptors, it shows... |
