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Search Results for " Kynurenine "

ターゲット

阻害剤

天然化合物

リコンビナントタンパク質

カタログ番号	製品名	別名	ターゲット
T3011L	Kynurenine sulfate monohydrate	L-Kynurenine sulfate monohydrate	Others
	Kynurenine sulfate monohydrate is a precursor of kynurenic acid which is the only recognized endogenous excitatory amino acid receptor antagonist agent in the central nervous system. L-Kyn is known to be a pigment genera...		Others
T37683	3-Hydroxykynurenine	3-hydroxy-DL-Kynurenine,DL-3-Hydroxykynurenine	Others
	3-Hydroxykynurenine (3-hydroxy-DL-Kynurenine) is an active metabolite of tryptophan and inhibits yeast and rat liver aldehyde dehydrogenase by 97 and 69%.		Others
T72430	L-Kynurenine sulfate		Others
	L-Kynurenine sulfate, an aryl hydrocarbon receptor (AHR) agonist, activates AHR-driven polarization of naive T cells towards the anti-inflammatory Treg phenotype.		Others
T1896	Ro 61-8048		Hydroxylase
	Ro 61-8048 is a potent and selective inhibitor of kynurenine hydroxylase with an IC50 value of 37 nM.		Hydroxylase
T4410	LM10		Others
	Selective tryptophan 2, 3-dioxygenase (TDO) inhibitor (IC50 values are 0.62 and 2 μM for human and mouse TDO, respectively). Exhibits selectivity for TDO over IDO, MAO-A, MAO-B, and a panel of receptors and transporters....		Others
T71760	4-Chlorokynurenine		Others
	4-Chlorokynurenine is a prodrug of 7-Cl-kynurenic acid (7-Cl-KYNA), a potent, selective antagonist of the NMDA/glycine receptor.		Others
T28368	PF-04859989 HCl	PF 04859989,PF04859989,PF-04859989HCl,PF-04859989	Others
	PF-04859989 HCl is a brain-penetrable irreversible inhibitor of kynurenine amino transferase II (KAT II), the enzyme responsible for most of the brain synthesis of kynurenic acid. PF-04859989 HCl has been implicated in s...		Others
T26785	BFF122	BFF 122,BF5,BFF-122	Others
	BFF122 is an inhibitor of kynurenine aminotransferase II (KAT II).		Others
T13258L	UPF-648		Others
	UPF-648 is a potent kynurenine 3-monooxygenase inhibitor. It also shows highly active at 1 uM (81 ± 10% KMO inhibition).		Others
T70041	GSK065		Others
	GSK065 is a potent inhibitor of kynurenine-3-monooxygenase (KMO).		Others
T70701	CHDI340246		Others
	CHDI-340246 is a potent and selective kynurenine mono-oxygenase (KMO) inhibitor.		Others
T15426	GSK180		Hydroxylase
	GSK180 is a selective competitive inhibitor of kynurenine 3-monooxygenase (KMO; IC50: ~6 nM), an enzyme involved in tryptophan metabolism.		Hydroxylase
T11470	GSK 366		Hydroxylase
	GSK 366 is a potent kynurenine-3-monooxygenase (KMO) inhibitor (IC50s: 0.7 nM and 2.3 nM for P. fluorescens-KMO and human KMO).		Hydroxylase
T13258	UPF-648 sodium salt		Others
	UPF-648 sodium salt is an inhibitor of kynurenine 3-monooxygenase (KMO) and exhibits highly active at 1 uM (81 ± 10% KMO inhibition).		Others
T24617	PF-04859989		Others
	PF-04859989 is a brain-penetrable irreversible inhibitor of kynurenine amino transferase II. PF-04859989 is ~1000-fold selective for KAT II over human KAT I, KAT III, and KAT IV. PF-04859989 has IC50 values of 23 nM for ...		Others
T63613	JM6		Others
	JM6 is a weak kynurenine 3-monooxygenase (KMO) inhibitor that acts on mouse KMO (IC50: 19.85 μM). JM6 can be used to study Alzheimer's disease.		Others
T69944	NLG802 HCl		Others
	NLG802 is an orally bioavailable prodrug of indoximod, a methylated tryptophan, with immune checkpoint inhibitory and antineoplastic activities. Upon oral administration, the indoximod prodrug NLG802 is converted to indo...		Others
T4532L	Linrodostat mesylate	ONO-7701,BMS-986205,ONO 7701,BMS986205,BMS 986205	Others
	Linrodostat (BMS-986205, ONO-7701, and F001287) is a selective and orally active IDO1 inhibitor with potential immunomodulating and antineoplastic activities. By inhibiting IDO1 and reducing kynurenine in tumor cells, BM...		Others
T84434	Kynurenic Acid hydrate	KYNA	Others
	Kynurenic acid, an active metabolite of tryptophan, is synthesized through a kynurenine intermediate by kynurenine aminotransferases (KATs). It acts as an antagonist of both NMDA and AMPA receptors, as well as α7 nicotin...		Others
T73581	HI5		Others
	HI5, a potent inhibitor of tubulin and indoleamine 2,3-dioxygenase (IDO), exhibits an inhibitory concentration (IC50) of 70 nM in HeLa cells. It suppresses IDO expression, reduces kynurenine production, and enhances T ce...		Others

Compounds

Kynurenine sulfate monohydrate

T3011L

Synonym: L-Kynurenine sulfate monohydrate

Target: Others

3-Hydroxykynurenine

T37683

Synonym: 3-hydroxy-DL-Kynurenine,DL-3-Hydroxykynurenine

Target: Others

L-Kynurenine sulfate

Synonym: PF 04859989,PF04859989,PF-04859989HCl,PF-04859989

Target: Others

BFF122

T26785

Synonym: BFF 122,BF5,BFF-122

Synonym: ONO-7701,BMS-986205,ONO 7701,BMS986205,BMS 986205

Target: Others

Kynurenic Acid hydrate

カタログ番号	製品名	別名	ターゲット
T4928	L-Kynurenine	(S)-Kynurenine	AhR , Aryl Hydrocarbon Receptor , Endogenous Metabolite
	L-Kynurenine ((S)-Kynurenine) is a key intermediate in the breakdown pathway of tryptophan. L-Kynurenine is a substrate of kynureninase, KMO, and KAT associated with the suppression of antitumor immune responses. It has ...		AhR , Aryl Hydrocarbon Receptor , Endogenous Metabolite
T10938	D-Kynurenine	(R)-2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid,ZINC901103	GPR , AhR , Endogenous Metabolite
			GPR , AhR , Endogenous Metabolite
T3011	2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid	Kynurenine,Dl-Kynurenine,Kynurenin,3-Anthraniloylalanine	Others , Endogenous Metabolite
	2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid is a ketone and amino acid derivative with a variety of biological functions including vasodilatory, immunomodulatory, and neuromodulatory activities.2-Amino-4-(2-aminophenyl)...		Others , Endogenous Metabolite
T4096	Quinolinic acid	pyridine-2,3-dicarboxylic acid,QUIN	Endogenous Metabolite , NMDAR , iGluR
	Quinolinic acid (QUIN) is an endogenous N-methyl-D-aspartate (NMDA) receptor agonist synthesized from L-tryptophan via the kynurenine pathway.		Endogenous Metabolite , NMDAR , iGluR
T4707	3-Hydroxyanthranilic acid	3-HYDROXY-2-AMINOBENZOIC ACID	Others , Antioxidant , Endogenous Metabolite
	3-Hydroxyanthranilic acid is a tryptophan metabolite in the kynurenine pathway. It has been found in human epidermis and bladder tissue and has been detected in a variety of biological fluids such as urine and blood. Wit...		Others , Antioxidant , Endogenous Metabolite
T80656	Cannflavin A		Others
	Cannflavin A, isolated from Cannabis sativa L., exhibits anti-cancer, neuroprotective, and anti-inflammatory activities by inhibiting Aβ1-42 aggregation and kynurenine-3-monooxygenase (KMO), as well as inducing apoptosis...		Others

天然物製品

L-Kynurenine

T4928

Synonym: (S)-Kynurenine

Target: AhR, Aryl Hydrocarbon Receptor, Endogenous Metabolite

D-Kynurenine

T10938

Synonym: (R)-2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid,ZINC901103

Target: GPR, AhR, Endogenous Metabolite

2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid

T3011

Synonym: Kynurenine,Dl-Kynurenine,Kynurenin,3-Anthraniloylalanine

Target: Others, Endogenous Metabolite

Quinolinic acid

T4096

Synonym: pyridine-2,3-dicarboxylic acid,QUIN

Target: Endogenous Metabolite, NMDAR, iGluR

3-Hydroxyanthranilic acid

T4707

Synonym: 3-HYDROXY-2-AMINOBENZOIC ACID

Target: Others, Antioxidant, Endogenous Metabolite

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPH-01598	CCBL2 Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	CCBL2 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 67.4 kDa and the accession number is Q6YP21.
TMPH-01596	AADAT Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a vari...
TMPH-01595	KMO Protein, Human, Recombinant (His)	Human	E. coli
	Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA r...
TMPH-01597	KYAT1 Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA), an intermediate in the tryptophan catabolic pathway which is also a broad spectrum antagonist of the thre...
TMPY-02803	IDO2 Protein, Human, Recombinant (His)	Human	E. coli
	IDO2 belongs to the indoleamine 2,3-dioxygenase family. Indoleamine 2,3-dioxgyenase (IDO), is a cytosolic haem protein which, together with the hepatic enzyme tryptophan 2,3-dioxygenase, catalyzes the conversion of trypt...