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T1488 |
Procarbazine hydrochloride
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NSC-77213 HCl,Procarbazine HCl |
DNA Alkylator/Crosslinker
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DNA/RNA Synthesis
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Procarbazine hydrochloride (NSC-77213 HCl) is the hydrochloride salt of a methylhydrazine derivative with antineoplastic and mutagenic activities. Although the exact mode of cytotoxicity has not been elucidated, procarba... |
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T6632 |
Raltitrexed
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ZD1694,D1694,ICI-D1694,Tomudex |
Nucleoside Antimetabolite/Analog
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DNA/RNA Synthesis
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Raltitrexed (D1694)(IC50 of 9 nM), a thymidylate synthase inhibitor, is used for the inhibition of L1210 cell growth. |
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T1349 |
5-Fluorouridine
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Others
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DNA/RNA Synthesis
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5-fluorouridine is also known as FUrd, 5-Fluorouracil 1-beta-D-ribofuranoside, 5-Fur, or 5-Fluoro-uridine. 5-fluorouridine is a solid. This compound belongs to the pyrimidine nucleosides and analogues. These are compound... |
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T24990 |
8-Deazafolic acid
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NSC-173522,NSC173522,NSC 173522 |
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8-Deazafolic acid is a potent folate-dependent bacteria inhibitor, Streptococcus faecium (ATCC 8043) and Lactobacillus casei (ATCC 7469), and to have activity against lymphoid leukemia L1210 in mice. |
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T69199 |
Homopteroic Acid
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Homopteroic Acid is an intermediate in the synthesis of Homofolic Acid which inhibits the growth of L1210 mouse leukemia cells when intracellular folates are acquired via the high-affinity folate binding protein. |
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T69172 |
Acetomycin
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Acetomycin is a γ-lactone microbial metabolite originally isolated from S. ramulosus that has anticancer activity. It inhibits proliferation of HCT-8 human colon and L1210 mouse leukemia cancer cells. |
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T68952 |
NU1064
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NU1064 is a potent poly(ADP-ribose) polymerase (PARP) inhibitor, which can potentiate the cytotoxicity of a panel of mechanistically diverse anti-cancer agents in L1210 cells. NU1064 potentiated a sublethal concentration... |
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T69057 |
Elliptinium acetate
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NSC 264137,Celiptium,NSC 264137 ; Celiptium |
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Elliptinium acetate (NSC 264137), a DNA intercalating agent, exhibits high cytotoxicity towards L1210 cells and forms covalent bonds with nucleic acids from these cells. It holds potential in cancer research, especially ... |
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T70304 |
CI-898 HCl
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CI-898 HCl is a lipophilic antifolate inhibitor of dihydrofolate reductase (DHFR). It has enhanced binding to DHFR in the presence of the cofactor NADPH. Cl-898 HCl inhibits cell growth and halts the cell cycle at the G1... |
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T38383 |
Altemicidin
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Altemicidin is a monoterpene alkaloid originally isolated fromS. sioyaensiswith acaricidal and anticancer activities.1It is acaricidal to two-spotted spider mites (T. urticae) in a greenhouse pot test at concentrations o... |
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T38101 |
Bisucaberin
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Bisucaberin is a siderophore and bacterial metabolite that has been found inA. haloplanktisand has anticancer activity.1,2It inhibits the growth of L1210 and 1MC carcinoma cells (IC50s = 9.7 and 12.7 μM, respectively) an... |
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T36477 |
Urdamycin A
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Urdamycin A is a bacterial metabolite originally isolated fromS. fradiaethat has antibacterial and anticancer activities.1,2It is active against a variety of Gram-positive and Gram-negative bacteria, includingB. subtilis... |
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T68667 |
Oxanosine
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Oxanosine is an analog of guanosine that has been found in S. capreolus and has diverse biological activities, including antibacterial, antiviral, and anticancer properties. It is active against a variety of bacteria, in... |
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T36748 |
Heliquinomycin
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Heliquinomycin is a bacterial metabolite originally isolated fromStreptomycesthat has diverse biological activities.1It is active against a variety of Gram-positive bacteria, including strains ofB. anthracis, B. subtilis... |
