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T1485 |
Methotrexate
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NCI-C04671,WR19039,Amethopterin,CL14377 |
Apoptosis
,
Dehydrogenase
,
DNA/RNA Synthesis
,
Antifolate
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Methotrexate (WR19039) is a folate analog, an inhibitor of the dihydrofolate reductase DHFR. Methotrexate has antimetabolic, antitumor, and immunosuppressive activities, and is commonly used in rheumatoid arthritis and v... |
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T8003 |
Methotrexate disodium
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Apoptosis
,
Dehydrogenase
,
DNA/RNA Synthesis
,
Antifolate
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Methotrexate disodium is an tetrahydrofolate dehydrogenase inhibitor |
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T16045 |
Methotrexate metabolite
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DAMPA |
Antifolate
,
Drug Metabolite
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Methotrexate metabolite (DAMPA) (DAMPA) is the active metabolite of Methotrexate. Methotrexate is a folic acid antagonist. Methotrexate is used as a chemotherapeutic agent and immunosuppressant. |
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T28027 |
Methotrexate monohydrate
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Methotrexate hydrate |
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Methotrexate monohydrate is a DHhF reductase inhibitor. Methotrexate monohydrate increases T cell apoptosis, decreases T cell activation and suppresses cytokine production. |
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T25244 |
Chloromethylketone methotrexate
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Methotrexate chloromethylketone analog |
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Chloromethylketone methotrexate is an analog of methotrexate and a potential antitumor. |
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T25322 |
Diazoketone methotrexate
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Methotrexate diazoketone analog |
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Diazoketone methotrexate is an analog of methotrexate with potential antitumor activity. |
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T25796 |
Methotrexate 1-methyl ester
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Methotrexate related compound I,Methotrexate alpha-methyl ester |
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Methotrexate 1-methyl ester is an impurity of Methotrexate which is a folic acid antagonist. It's used as an antineoplastic and antirheumatic. |
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T25887 |
Methotrexate Triglutamate
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MTXPG3,NSC-341076,NSC 341076,NSC341076 |
Others
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Methotrexate Triglutamate (MTXPG3) has potential anti-inflammatory activity and can be used to study arthritis and lupus erythematosus. |
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T25886 |
Methotrexate Diglutamate
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NSC-269401,NSC 269401,NSC269401 |
DHFR
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Methotrexate Diglutamate Small molecule compound present in the liver that acts as a partially purified human dihydrofolate reductase inhibitor. |
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T37269 |
7-hydroxy Methotrexate (sodium salt)
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7-hydroxy Methotrexate (sodium salt),7-hydroxy MTX |
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7-hydroxy Methotrexate (sodium salt) is the major metabolite of Methotrexate (T1485). |
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T29486 |
7-Methotrexate
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7-Mtx |
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7-Methotrexate is used as a chemotherapy agent and immune system suppressant. It is used to treat cancer, autoimmune diseases, ectopic pregnancy, and medical abortions. |
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T24427 |
Lysine-methotrexate
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ADMPL |
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Lysine-methotrexate is an anticancer drug. It is an inhibitor of dihydrofolate reductase. |
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T69257 |
Methotrexate diethyl ester
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Methotrexate diethyl ester is an antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of tetrahydrofoltae dehydrogenase and prevents the formation of tetrahydrofolate, necessary for synthes... |
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T24456 |
Methotrexate-alpha-alanine
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Mtx-ala |
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Methotrexate-alpha-alanine is a prodrug. |
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T29454 |
5-Hexadecyl methotrexate
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Hexadecyl-mtx |
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5-Hexadecyl methotrexate is a amphipathic analog of methotrexate. |
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T24571 |
Ornithine-methotrexate
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ADMPO |
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Ornithine-methotrexate is a ornithine analog of methotrexate. It is an inhibitors of dihydrofolate reductase. |
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T69177 |
Methotrexate di-n-butyl ester
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Methotrexate di-n-butyl ester is an antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of tetrahydrofoltae dehydrogenase and prevents the formation of tetrahydrofolate, necessary for synt... |
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T33327 |
Methotrexate-gamma-monoamide
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Methotrexate-gamma-monoamide is a Methotrexate analog. |
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T24457 |
Methotrexate-gamma-aspartate
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Methotrexate-gamma-aspartate has growth inhibitory effects. It is used in antibody-targeted liposomes. |
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T24985 |
5-Monobutyl methotrexate
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NSC-305986,gamma-Mbmtx,NSC 305986,NSC305986 |
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5-Monobutyl methotrexate is an antineoplastic antimetabolite with immunosuppressant properties. It is a TETRAHYDROFOLATE DEHYDROGENASE inhibitor and prevents the formation of tetrahydrofolate, necessary for synthesis of ... |
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T33326 |
Methotrexate-alpha glutamate
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Meapa-glu-glu |
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Methotrexate-alpha glutamate is a chemotherapy agent and immune system suppressant. It is used to treat cancer, autoimmune diseases, ectopic pregnancy, and medical abortions. |
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T31908 |
Gamma-tert-Butyl methotrexate
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gamma-Tbmtx,NSC378900,NSC-378900,NSC 378900 |
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gamma-tert-Butyl methotrexate is a bioactive chemical. |
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T25797 |
Methotrexate 5-methyl ester
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Methotrexate 5-methyl ester is an impurity of Methotrexate which is a folic acid antagonist. It's used as an antineoplastic and antirheumatic. |
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T65289 |
Methotrexate (hydrate)
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Methotrexate (hydrate) is a useful organic compound for research related to life sciences. The catalog number is T65289 and the CAS number is 133073-73-1. |
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T20339 |
7-Hydroxymethotrexate
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NSC 380963,NSC-380963,NSC380962,NSC380963,NSC 380962,NSC-380962 |
Drug Metabolite
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7-Hydroxymethotrexate is the major metabolite of Methotrexate.Methotrexate is an inhibitor of folic acid, inhibiting dihydrofolate reductase, which prevents the conversion of folic acid to tetrahydrofolate, and inhibitin... |
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T29484 |
7-Hydroxydichloromethotrexate
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7Hdcm,7 Hdcm,7-Hdcm |
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7-Hydroxydichloromethotrexate is a methotrexate metabolite. |
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T68629 |
Lysine-iodoacetylmethotrexate
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Lysine-iodoacetylmethotrexate if a Folic Acid Antagonist. |
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T25335 |
Dioleoylmethotrexate
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Dioleoylmethotrexate is an antineoplastic. |
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T30593 |
Bromochloromethotrexate
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NSC 98579,NSC98579,NSC-98579 |
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Bromochloromethotrexate is a bioactive chemical. |
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T25324 |
Dichloromethotrexate
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NSC 29630,3988-B-129-4,NSC29630,Dichloroamethopterin,NSC-29630 |
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Dichloromethotrexate is an enzyme dihydrofolate reductase inhibitor, thus preventing the synthesis of purine nucleotides and thymidylates and inhibiting DNA and RNA synthesis. This agent is metabolized and excreted by th... |
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T29391 |
3'-Chloromethotrexate
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NSC 29631,NSC29631,SKI 23338,NSC-29631,AI3-50533 |
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3'-Chloromethotrexate is a chemotherapy agent and immune system suppressant. It can be used to treat cancer, autoimmune diseases, ectopic pregnancy, and medical abortions. |
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T34822 |
Tetrahydromethotrexate
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NSC 526044,NSC-526044,NSC526044 |
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Tetrahydromethotrexate is a folic acid derivative. |
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T33741 |
NSC 174121
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NSC-174121,NSC174121 |
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NSC 174121 is a methotrexate derivative. |
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T73358 |
(-)SHIN2
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(-)SHIN2 is the isomer of (+)SHIN2 . (+)SHIN2 is an inhibitor of serine hydroxymethyltransferase (SHMT) with antileukemic effect. (+)SHIN2 synergisty with and Methotrexate in vivo xenotransplantation models [1] . |
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T20340 |
10-Formyldihydrofolate
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10-Formyldihydrofolate is a Methotrexate metabolite. It inhibits thymidylate synthetase and glycinamide ribotide transformylase. |
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T74009 |
1,1,3-Tribromoacetone
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1,1,3-Tribromoacetone is an impurity of Methotrexate [1]. Methotrexate is an antimetabolite and antifolate drug that blocks the enzyme dihydrofolate reductase, stopping the transformation of folic acid into tetrahydrofol... |
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T63743 |
Folinic acid calcium hydrate
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Folinic acid (Leucovorin) calcium hydrate is a biofolic acid often used as a rescue agent with methotrexate (MTX) to reduce MTX-induced toxicity. |
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T68661 |
Edatrexate
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CGP 30694 |
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Edatrexate (CGP 30694), also known as 10-Ethyl-10-deazaaminopterin, is an analog of Methotrexate that demonstrates antitumor activity against Methotrexate-resistant tumors. This antifolate antimetabolite is utilized in r... |
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T75839 |
Kisspeptin-10, rat TFA
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Kisspeptin-10, rat TFA serves as both a potent vasoconstrictor and an inhibitor of angiogenesis, as well as acting as a ligand for the rodent kisspeptin receptor (KISS1, GPR54). Additionally, Kisspeptin-10 TFA demonstrat... |
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T41148 |
Phototrexate
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Phototrexate is a photoswitchable potent inhibitor of human dihydrofolate reductase (DHFR). Phototrexate is a photochromic analog of Methotrexate. Antifolate activity is switched on (cis-Phototrexate) by UVA (375 nm) lig... |
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T70304 |
CI-898 HCl
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CI-898 HCl is a lipophilic antifolate inhibitor of dihydrofolate reductase (DHFR). It has enhanced binding to DHFR in the presence of the cofactor NADPH. Cl-898 HCl inhibits cell growth and halts the cell cycle at the G1... |
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T69451 |
R-130823
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R-130823 is a ighly selective inhibition against mitogen-activated protein kinase p38alpha (IC50=22 nM). The release of tumor necrosis factor-alpha, interleukin-1beta, -6 and -8 was inhibited in lipopolysaccharide-stimul... |
