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Search Results for " NADH "

阻害剤

天然化合物

リコンビナントタンパク質

カタログ番号	製品名	別名	ターゲット
T36420	IM-156 acetate	HL271 acetate
	IM-156 acetate, an activator of NADH dehydrogenase (IC50=2.2 μM) and AMP-activated protein kinase alpha (AMPKα), is an orally available and bioavailable inhibitor of mitochondrial oxidative phosphorylation (OxPhos).IM-15...
T73486	RIG012		Others
	RIG012 is a potent RIG-I inhibitor with an IC50 value of 0.71 μM measured by NADH-coupled ATPase.RIG012 inhibited the expression of IFN-β and ISG hRsad2.		Others
T7575L1	[Sar1, Ile8]-Angiotensin II acetate		RAAS
	[Sar1, Ile8]-Angiotensin II acetate activates both the NADPH and NADH oxidases, and stimulates superoxide anion formation in vascular smooth muscle cells. [Sar1, Ile8]-Angiotensin II acetate has multiple effects on vascu...		RAAS
T20067	WST-1	WST 1
	WST-1 is a cytotoxic, water-soluble tetrazolium salt that induces intracellular mitochondrial dehydrogenases to undergo NADH-dependent enzymatic reactions, releasing water-soluble methylbenzene products.WST-1 can be used...
T60774	NITD-916	NITD916,NITD 916	Antibiotic
	NITD-916 is an orally active and highly lipophilic inhibitor of Mycobacterium enoyl reductase InhA with an IC50 of 570 nM.NITD-916 is a potent 4-hydroxy-2-pyridone derivative that forms a ternary complex with InhA and NA...		Antibiotic
T9558	KL-11743		transporter
	KL-11743 specifically blocks glucose metabolism, triggering an acute collapse in NADH pools and a striking accumulation of aspartate, indicating a dramatic shift toward oxidative phosphorylation in the mitochondria.		transporter
T22223	3PO		Glucokinase , Autophagy
	3PO is a small-molecule inhibitor of PFKFB3 (IC50: 22.9 μM), inhibiting the proliferation of several human malignant hematopoietic and adenocarcinoma cell lines (IC50: 1.4-24 μM). It suppresses glucose uptake, and decrea...		Glucokinase , Autophagy
T16342	KL1333	NQO1 activator 1	NADPH , Mitochondrial Metabolism
	KL1333 (NQO1 activator 1) enhances energy metabolism and mitochondrial dysfunction in MELAS fibroblasts. Elevated NAD+ levels trigger the activation of SIRT1 and AMPK, and subsequently activates PGC-1α. NQO1 activator 1 ...		NADPH , Mitochondrial Metabolism
T71866	Cochlioquinone B
	Cochlioquinone B is a phytotoxin that inhibits NADH oxidase and NADH-2,3-dimethoxy-5-pentyl-1,4-benzoquinone reductase from heart mitochondria.
T70935	Phenoxan
	Phenoxan is isolated from Polyangium; inhibits electron transport at NADH-ubiquinone oxidoreductase.
T36875	Sartorypyrone D
	Sartorypyrone D is a fungal metabolite that has been found inN. fischeri.1It inhibits NADH fumarate reductase (NFRD; IC50= 1.7 μM inA. suummitochondria) and NADH oxidase (IC50= 3 μM in bovine heart mitochondria). Sartory...
T75289	NAD sodium
	NAD sodium (β-Nicotinamide Adenine Dinucleotide sodium) is an analogue of NAD that can be reduced to β-nicotinamide adenine dinucleotide (NADH) through reactions that oxidize organic substrates. Furthermore, NAD sodium c...
T61192	CBR-6672
	CBR-6672, a type II NADH dehydrogenase inhibitor, demonstrates potent antimycobacterial activity against mycobacterium tuberculosis (Mtb) with a minimum inhibitory concentration (MIC) of 0.14 μM [1].
T76116	L-Lactate dehydrogenase
	L-Lactate dehydrogenase, a redox enzyme, catalyzes the in vivo reduction of pyruvate to L-lactate with absolute enantiospecificity by utilizing NADH [1].
T68317	VJ115
	VJ115 is a novel chemical entity that inhibits the enzyme ENOX1, a NADH oxidase. Genetic and small molecule inhibition of ENOX1 inhibits endothelial cell tubule formation and tumor-mediated neo-angiogenesis. Inhibition o...
T76207	Glucose dehydrogenase (GDH)
	Glucose dehydrogenase (GDH) is an oxidoreductase enzyme that facilitates the oxidation of β-D-glucose into β-D-glucono-1,5-lactone, while concurrently reducing cofactor NADP+ to NADPH, and to a lesser degree, NAD+ to NAD...
T78360	Glyceraldehyde phosphate dehydrogenase	GAPDH,G3PDH,GADPH
	Glyceraldehyde phosphate dehydrogenase, targeted by anti-thymocyte and anti-apoptotic agents, catalyzes the oxidation of reduced nicotinamide adenine dinucleotide (NADH) by perhydroxyl radicals [1] [2].
T61035	CBR-3465
	CBR-3465 is an inhibitor of mycobacterium tuberculosis (Mtb) type II NADH dehydrogenase. The MIC of CBR-3465 against Mtb is 0.16 μM [1].
T76206	Beta-Galactose dehydrogenase
	Beta-Galactose dehydrogenase catalyzes the conversion of galactose into galactonolactone, simultaneously reducing NAD to fluorescent NADH. This enzyme is useful for the determination of galactose [1].
T83800	6-Biotin-17-NAD+ sodium	6-Biotin-17-Nicotinamide adenine dinucleotide,β-Nicotinamide-N6-(2-(6-(6-[biotinyl]aminohexanoyl)aminohexanoyl)aminoethyl)adenine dinucleotide
	6-Biotin-17-NAD+, a biotinylated derivative of the signaling molecule and enzyme cofactor NAD+, is utilized in high-throughput screening (HTS) assays to measure the activity of mitochondrial complex I, also referred to a...
T37502	Sn-Glycerol 3-phosphate lithium
	sn-Glycerol 3-phosphate lithium is synthesized via the cytosolic glycerol 3-phosphate dehydrogenase pathway. This process involves the conversion of dihydroxyacetone phosphate to sn-Glycerol 3-phosphate using NADH, which...
T73478	ME-143	NV-143
	ME-143, a second-generation tumor-specific NADH oxidase inhibitor, exhibits efficacy by inhibiting the WNT/β-catenin pathway in colorectal cancer cells. Demonstrating broad activity against cancers both in vitro and in v...
T79252	Apoptosis inducer 13		Reactive Oxygen Species
	Apoptosis Inducer 13 (Compound Ru4) promotes apoptosis in cancer cells while also suppressing their migration and invasion. Additionally, it facilitates the conversion of coenzyme NADH to NAD+, and elevates intracellular...		Reactive Oxygen Species
T38230	Iromycin A
	Iromycin A is a bacterial pyridone metabolite that inhibits nitric oxide synthase (NOS) activity, with selectivity for NOS III (endothelial NOS) over NOS I (neuronal NOS). Iromycin metabolites and derivatives block NADH ...
T27568	IACS-010759 hydrochloride	IACS-010759 HCl,IACS-010759,IACS10759,IACS-10759,IACS 10759
	IACS-010759 is a potent inhibitor of complex I of OXPHOS with orally bioavailable. IACS-10759 effectively inhibits ATP production and oxygen consumption in isolated mitochondria, and inhibits the conversion of NADH to NA...
T73032	MtInhA-IN-1
	MtInhA-IN-1 is a potent, selective, and orally active inhibitor targeting the Mycobacterium tuberculosis NADH-dependent enoyl-acyl carrier protein reductase (MtInhA), demonstrating an IC50 of 0.23 μM. It exhibits strong ...
T37583	XTT (sodium salt hydrate)
	XTT is a cell-impermeable, negatively charged tetrazolium dye that produces a water-soluble formazan when reduced at the cell surface by cellular-derived NADH and an electron mediator.1,2It is frequently used in colorime...
T20016	Diuron	HW 920,Dirurol,Karmex,Lucenit,Marmer,Seduron
	Diuron is a Phenylurea herbicide that inhibits photosynthesis by preventing the formation of ATP and NADH. Diuron (25 nM/ml) decreases total respiration in roots of wheat by 50% and ground respiration by 100%. Diuron (2,...
T37070	Pyridomycin
	Pyridomycin is a structurally unusual antimycobacterial cyclodepsipeptide whose composition includes two rare moieties: 3-(3-pyridyl)-L-alanine and 2-hydroxy-3-methylpent-2-enoic acid. It inhibits NADH-dependent enoyl (A...
T83866	LCC-12 formate
	LCC-12, a derivative of the biguanide metformin, acts as a copper (II) chelator. It efficiently forms a monomeric bond with copper (II) and at 20 µM, it mitigates hydrogen peroxide-induced oxidation from NADH to NAD+. At...
T83865	HP661
	HP661, a selective inhibitor of mitochondrial complex I (NADH dehydrogenase), impedes complex I activity by 77.6% at 1 µM, demonstrating lesser inhibition towards complex III (28.1%) and no inhibitory effects on complexe...
T37692	Piericidin B
	Piericidin B is a bacterial metabolite that has been found inS. mobaraensisand has insecticidal and antimicrobial activities.1,2,3It inhibits NADH oxidase activity in isolated bovine heart mitochondria and inhibits respi...
T35712	Debutyldronedarone hydrochloride	SR35021 hydrochloride
	N-Desbutyl dronedarone is an active metabolite of the antiarrhythmic agent dronedarone .1,2,3It is formed from dronedarone by cytochrome P450s (CYPs) and monoamine oxidase (MAO) in human hepatocyte preparations.4N-Desbut...
T35520	Aflatoxin G1-13C17	Aflatoxin G1-13C17
	Aflatoxin G1-13C17is intended for use as an internal standard for the quantification of aflatoxin G1by GC- or LC-MS. Aflatoxin G1is a mycotoxin that has been found inA. terricola.1In vivo, aflatoxin G1is lethal to duckli...

Compounds

IM-156 acetate

T36420

Synonym: HL271 acetate

[Sar1, Ile8]-Angiotensin II acetate

Synonym: NITD916,NITD 916

Target: Glucokinase, Autophagy

KL1333

T16342

Synonym: NQO1 activator 1

Target: NADPH, Mitochondrial Metabolism

L-Lactate dehydrogenase

Glucose dehydrogenase (GDH)

T76207

Synonym:

Target:

Glyceraldehyde phosphate dehydrogenase

T78360

Synonym: GAPDH,G3PDH,GADPH

beta-Galactose dehydrogenase

T76206

Synonym:

Target:

6-Biotin-17-NAD+ sodium

T83800

Synonym: 6-Biotin-17-Nicotinamide adenine dinucleotide,β-Nicotinamide-N6-(2-(6-(6-[biotinyl]aminohexanoyl)aminohexanoyl)aminoethyl)adenine dinucleotide

Target:

sn-Glycerol 3-phosphate lithium

Target: Reactive Oxygen Species

IACS-010759 hydrochloride

T27568

Synonym: IACS-010759 HCl,IACS-010759,IACS10759,IACS-10759,IACS 10759

XTT (sodium salt hydrate)

Synonym: HW 920,Dirurol,Karmex,Lucenit,Marmer,Seduron

Debutyldronedarone hydrochloride

T35712

Synonym: SR35021 hydrochloride

Target:

Aflatoxin G1-13C17

T35520

Synonym: Aflatoxin G1-13C17

Target:

カタログ番号	製品名	別名	ターゲット
T5283	NADH disodium salt	Disodium NADH,NADH, disodium salt hydrate	Others , Endogenous Metabolite
	NADH disodium salt (Disodium NADH) hydrate is the reduced form of nicotinamide adenine dinucleotide (NAD) that can donate electrons as part of a reducing reaction. In that process, NADH disodium salt hydrate becomes oxid...		Others , Endogenous Metabolite
T8347	Rifamycin S		Reactive Oxygen Species , ROS , Antibacterial , Antibiotic
	Rifamycin S is a potent DNA-dependent RNA polymerase inhibitor,is a quinone and an antibiotic agnet against Gram-positive bacteria		Reactive Oxygen Species , ROS , Antibacterial , Antibiotic
TN1774	Isobavachromene		Others , Antibacterial
	Isobavachromene is an inhibitor of NADH-Ubiquinone oxidoreductase and ornithine decarboxylase. Isobavachromene has antifungal activity.		Others , Antibacterial
T19343	Sn-Glycerol 3-phosphate	Glycerol 3-phosphate,sn-Glycerol 3-phosphate lithium salt	Endogenous Metabolite
	sn-Glycerol 3-phosphate is produced by the reduction of dihydroxyacetone phosphate by NADH formed during glycolysis of the cytoplasmic glycerol 3-phosphate dehydrogenase pathway.		Endogenous Metabolite
T1609	NAD+	Cozymase,β-DPN,DPN,β-Nicotinamide Adenine Dinucleotide,β-NAD	NADPH , Endogenous Metabolite
	NAD+ (β-Nicotinamide Adenine Dinucleotide) is a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous...		NADPH , Endogenous Metabolite
T19343L	Glycerol 3-phosphate biscyclohexylammonium salt		Endogenous Metabolite
	Glycerol 3-phosphate biscyclohexylammonium salt is an endogenous metabolite produced by cytosolic glycerol 3-phosphate dehydrogenase pathway.		Endogenous Metabolite
T81570	Paecilaminol	FKI-0550
	Paecilaminol (FKI-0550) is a potent inhibitor of the NADH-fumarate reductase enzyme, demonstrating an inhibitory concentration (IC50) of 5.1 µM against the NADH-fumarate reductase derived from Ascaris suum [1].
T74201	3′-Hydroxy-4′-O-methylglabridin
	3′-Hydroxy-4′-O-methylglabridin effectively prevents NADH-dependent peroxidation, exhibiting potent antioxidant properties [1].
T40529	(R)-(-)-1,2-Propanediol
	(R)-(-)-1,2-Propanediol is the (R)-enantiomer of 1,2-Propanediol, which is derived from glucose through the expression of NADH-linked glycerol dehydrogenase genes in Escherichia coli.
TN3069	4beta-Carboxy-19-nortotarol		NADPH-oxidase
	4 beta-Carboxy-19-nortotarol can inhibit microsomal lipid peroxidation induced by Fe(III)-ADP/NADPH and mitochondrial lipid peroxidation induced by Fe(III)-ADP/ NADH, it inhibits linoleic acid autoxidation but not genera...		NADPH-oxidase
T80016	Aurachin D		Antibiotic
	Aurachin D is an antibiotic that inhibits Gram-positive bacteria and some fungi. It also blocks NADH oxidation in beef heart submitochondrial particles [1].		Antibiotic
T37714	Fuscin
	Fuscin is a quinonoid fungal metabolite originally isolated from O. fuscum that has diverse biological activities. It inhibits binding of the ADP/ATP translocase inhibitor atractyloside to rat liver mitochondria in an AD...

天然物製品

NADH disodium salt

T5283

Synonym: Disodium NADH,NADH, disodium salt hydrate

Target: Others, Endogenous Metabolite

Rifamycin S

T8347

Synonym:

Target: Reactive Oxygen Species, ROS, Antibacterial, Antibiotic

Isobavachromene

TN1774

Synonym:

Target: Others, Antibacterial

sn-Glycerol 3-phosphate

T19343

Synonym: Glycerol 3-phosphate,sn-Glycerol 3-phosphate lithium salt

Target: Endogenous Metabolite

NAD+

T1609

Synonym: Cozymase,β-DPN,DPN,β-Nicotinamide Adenine Dinucleotide,β-NAD

Target: NADPH, Endogenous Metabolite

Glycerol 3-phosphate biscyclohexylammonium salt

T19343L

Synonym:

Target: Endogenous Metabolite

3′-Hydroxy-4′-O-methylglabridin

T74201

Synonym:

Target:

(R)-(-)-1,2-Propanediol

T40529

Synonym:

Target:

4beta-Carboxy-19-nortotarol

TN3069

Synonym:

Target: NADPH-oxidase

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPH-00673	NADH pyrophosphatase Protein, E. coli O157:H7, Recombinant (His)	E. coli	E. coli
	mRNA decapping enzyme that specifically removes the nicotinamide adenine dinucleotide (NAD) cap from a subset of mRNAs by hydrolyzing the diphosphate linkage to produce nicotinamide mononucleotide (NMN) and 5' monophosph...
TMPH-03008	ENR Protein, Mycobacterium tuberculosis, Recombinant (His)	Mycobacterium tuberculosis	E. coli
	ENR Protein, Mycobacterium tuberculosis, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 32.6 kDa and the accession number is P9WGR0.
TMPY-02801	PHGDH Protein, Human, Recombinant (His)	Human	E. coli
	PHGDH is a member of the D-isomer specific 2-hydroxyacid dehydrogenase family. This new family consists of D-isomer-stereospecific enzymes. The conserved residues in this family appear to be the residues involved in the ...
TMPH-00162	MDH Protein, Bacillus methanolicus, Recombinant (His & Myc & SUMO)	Bacillus methanolicus	E. coli
	Catalyzes the oxidation of methanol to yield formaldehyde. It possesses a NADH-dependent formaldehyde reductase activity and cannot use NADP. MDH Protein, Bacillus methanolicus, Recombinant (His & Myc & SUMO) is expresse...
TMPH-00161	MDH Protein, Bacillus methanolicus, Recombinant (His)	Bacillus methanolicus	P. pastoris (Yeast)
	Catalyzes the oxidation of methanol to yield formaldehyde. It possesses a NADH-dependent formaldehyde reductase activity and cannot use NADP. MDH Protein, Bacillus methanolicus, Recombinant (His) is expressed in yeast wi...
TMPH-01302	HSD17B1 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	Favors the reduction of estrogens and androgens. Converts estrone (E1) to a more potent estrogen, 17beta-estradiol (E2). Also has 20-alpha-HSD activity. Uses preferentially NADH. HSD17B1 Protein, Human, Recombinant (His ...
TMPH-01691	TOMM40 Protein, Human, Recombinant (GST)	Human	E. coli
	Channel-forming protein essential for import of protein precursors into mitochondria. Plays a role in the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) by forming a complex with ...
TMPY-03755	Glycerol 3 Phosphate Dehydrogenase/GPD1 Protein, Human, Recombinant (His)	Human	E. coli
	GPD1 (Glycerol-3-Phosphate Dehydrogenase 1) is a Protein Coding gene. 2 alternatively spliced human isoforms have been reported. GPD1 is a member of the NAD-dependent glycerol-3-phosphate dehydrogenase family. The encode...
TMPK-00571	OSMR Protein, Canine, Recombinant (His)	Canine	HEK293 Cells
	OSMR is targeted to the mitochondrial matrix via the presequence translocase-associated motor complex components, mtHSP70 and TIM44. OSMR interacts with NADH ubiquinone oxidoreductase 1/2 (NDUFS1/2) of complex I and prom...
TMPK-00493	OSMR Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293 Cells
	OSMR is targeted to the mitochondrial matrix via the presequence translocase-associated motor complex components, mtHSP70 and TIM44. OSMR interacts with NADH ubiquinone oxidoreductase 1/2 (NDUFS1/2) of complex I and prom...
TMPJ-00956	MDH2 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Malate dehydrogenase, mitochondrial is a 338 amino acids protein that belongs to the LDH/MDH superfamily. MDH type 1 family. MDH2 catalyzes the reversible oxidation of malate to oxaloacetate, utilizing the NAD/NADH cofac...
TMPJ-00724	LDHA Protein, Human, Recombinant (His)	Human	E. coli
	L-Lactate Dehydrogenase A Chain (LDHA) is an enzyme that catalyzes the conversion of L-lactate and NAD+ to pyruvate and NADH in the final step of anaerobic glycolysis. LDHA contains an N-terminal coenzyme binding region,...
TMPH-00916	ADH1B Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Catalyzes the NAD-dependent oxidation of all-trans-retinol and its derivatives such as all-trans-4-hydroxyretinol and may participate in retinoid metabolism. In vitro can also catalyzes the NADH-dependent reduction of al...
TMPJ-01009	BLVRA Protein, Human, Recombinant (His)	Human	E. coli
	Human Biliverdin reductase A (BLVRA) is belonged to the Gfo/Idh/MocA family and Biliverdin reductase subfamily. BLVRA is an enzyme that in humans is encoded by the BLVRA gene. BLVRA plays an important role in reducing th...
TMPJ-00797	LDHB Protein, Human, Recombinant (His)	Human	E. coli
	L-Lactate Dehydrogenase B Chain (LDH-B) is a member of the lactate dehydrogenase family that consists of three members, LDH-A, LDH-B and LDH-C; members of this family function as powerful markers for germ cell tumors. LD...
TMPY-03497	AKR1C2 Protein, Human, Recombinant (His)	Human	E. coli
	AKR1C2 is a member of the aldo/keto reductase superfamily, which consists of more than 4 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols using ...
TMPY-01812	Enoyl-ACP Reductase Protein, E. coli, Recombinant (His)	E. coli	E. coli
	Enoyl-ACP reductase, also known as NADH-dependent enoyl-ACP reductase and FABI, is a cell inner membrane and peripheral membrane protein which belongs to theshort-chain dehydrogenases/reductases (SDR) family and FabI ...
TMPY-02599	MDH1 Protein, Rat, Recombinant (His)	Rat	E. coli
	Malate dehydrogenases 1(MDH1 / MDHA) is a soluble form of malate dehydrogenases. Malate dehydrogenases (MDH) is a group of multimeric enzymes consisting of identical subunits usually organized as either dimer or tetramer...
TMPH-02617	COX5A Protein, Mouse, Recombinant (His & SUMO)	Mouse	E. coli
	Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase...
TMPY-02519	BLVRB Protein, Human, Recombinant (His)	Human	E. coli
	Biliverdin reductase (hBVR) is a serine/threonine kinase that catalyzes reduction of the heme oxygenase (HO) activity product, biliverdin, to bilirubin. BVR consists of an N-terminal dinucleotide-binding domain (Rossmann...
TMPY-01869	SIRT1 Protein, Human, Recombinant (His)	Human	E. coli
	SIRT1 belongs to the sirtuin family. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. SIRT1 is included in class I of the sirtuin family. It is a NAD-dependent prote...