Powder: -20°C for 3 years | In solvent: -80°C for 1 year
KL-11743 specifically blocks glucose metabolism, triggering an acute collapse in NADH pools and a striking accumulation of aspartate, indicating a dramatic shift toward oxidative phosphorylation in the mitochondria.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 26,500 | |||
5 mg | 在庫あり | ¥ 57,000 | |||
10 mg | 在庫あり | ¥ 91,500 | |||
25 mg | 在庫あり | ¥ 152,500 | |||
50 mg | 在庫あり | ¥ 217,000 | |||
100 mg | 在庫あり | ¥ 294,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 65,000 |
説明 | KL-11743 specifically blocks glucose metabolism, triggering an acute collapse in NADH pools and a striking accumulation of aspartate, indicating a dramatic shift toward oxidative phosphorylation in the mitochondria. |
ターゲット&IC50 | GLUT3:90 nM (IC50), GLUT4:68 nM (IC50), GLUT2:137 nM (IC50), GLUT1:115 nM (IC50) |
In vitro | Patient-derived xenograft models of succinate dehydrogenase A (SDHA)-deficient cancers are specifically sensitive to KL-11743, providing direct evidence that TCA cycle-mutant tumors are vulnerable to GLUT inhibitors in vivo[1]. |
分子量 | 522.6 |
分子式 | C30H30N6O3 |
CAS No. | 1369452-53-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 25 mg/mL (47.84 mM)
You can also refer to dose conversion for different animals. 詳細
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KL-11743 1369452-53-8 Metabolism transporter GLUT inhibit Inhibitor GLUT1 GLUT2 KL 11743 GLUT3 KL11743 glucose GLUT4 Glucose transporter inhibitor