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T62407 |
PDHK-IN-4
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PDHK-IN-4 (Compound 30) is a potent inhibitor of PDHK, acting on PDHK2 (IC50: 0.0051 μM) and PDHK4 (IC50: 0.0122 μM). PDHK-IN-4 has the potential to be investigated in cancer diseases. |
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T63327 |
PDHK-IN-5
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PDHK-IN-5 is a potent inhibitor of PDHK, acting on PDHK2 (IC50: 0.006 μM) and PDHK4 (IC50: 0.0329 μM), which are drug targets for many diseases including diabetes and cancer. PDHK-IN-5 has the potential to be investigate... |
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T60527 |
PDHK-IN-3
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PDHK-IN-3 (compound 7) is a potent inhibitor of pyruvate dehydrogenase kinase(PDHK) with IC50s of 0.21 and 1.54 μM for PDHK2 and PDHK4, respectively [1]. |
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T22350 |
JX06
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Apoptosis
,
Dehydrogenase
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PDK
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JX06, a potent, selective and covalent PDK inhibitor, inhibits PDK1, PDK2 and PDK3 with IC50 of 49 nM, 101 nM and 313 nM respectively. |
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T2447 |
AZD7545
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Dehydrogenase
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AZD7545 is a potent PDHK inhibitor. |
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T17224 |
VER-246608
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Dehydrogenase
,
PDK
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VER-246608 is an effective and ATP-competitive inhibitor of pyruvate dehydrogenase kinase (IC50s: 35 nM, 40 nM, 84 nM, and 91 nM for PDK-1, PDK-3, PDK-2, and PDK-4, respectively).VER-246608 disrupts Warburg metabolism an... |
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T11765 |
KPLH1130
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Dehydrogenase
,
PDK
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KPLH1130, a specific pyruvate dehydrogenase kinase (PDK) inhibitor, enhances glucose tolerance in mice fed a high-fat diet (HFD). It effectively hinders macrophage polarization and mitigates proinflammatory reactions. |
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T12412L |
PDK4-IN-1 hydrochloride
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Apoptosis
,
PDK
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T19783 |
Dehydroabiethylamine
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NSC-2955,NSC 2955,Dehydroabietylamine,NSC2955,Leelamine free base,Leelamine |
P450
,
PDK
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Dehydroabiethylamine (NSC-2955) is an inducer of hepatic CYP2B activity. Dehydroabiethylamine inhibits pyruvate dehydrogenase kinases (PDKs) and intracellular cholesterol transport with anti-tumor activity. |
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T37355 |
CAY10703
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Dichloroacetate (DCA) is an inhibitor of all pyruvate dehydrogenase kinase (PDHK) isoforms, which are enzymes that phosphorylate and inhibit PDH in mitochondria. Inhibition of PDHK shifts cell metabolism from glycolysis ... |
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T63012 |
TM-1
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TM-1 is a potent pyruvate dehydrogenase kinase (PDHK) inhibitor that inhibits the activity of PDHK1 (IC50: 2.97 μM) and PDHK2 (IC50: 5.2 μM). TM-1 blocks pyruvate dehydrogenase complex (PDHC) phosphorylation and inhibits... |
