|
T0396 |
Pipemidic acid
|
Acido pipemidico |
Antibacterial
,
Antibiotic
|
|
Pipemidic acid (Acido pipemidico), a new antibacterial agent, inhibits the activity of Pseudomonas aeruginosa. |
|
T4201 |
Avibactam sodium
|
AVE-1330A,NXL-104 |
Antibacterial
,
Antibiotic
|
|
Avibactam sodium (NXL-104) is a reversible β-lactamase inhibitor (IC50: 8/80/38 nM, for TEM-1/P99/KPC-2 β-lactamases). |
|
T1293 |
Gatifloxacin
|
BMS 206584-01,PD 135432,CG5501,BMS-206584,AM-1155 |
Topoisomerase
,
Antibacterial
,
Antibiotic
|
|
Gatifloxacin (CG5501) is an antibiotic of the fourth-generation fluoroquinolone family, that like other members of that family, inhibits the bacterial enzymes DNA gyrase and topoisomerase IV. |
|
T20711 |
Hemipyocyanine
|
528-71-2 |
Amylase
|
|
Hemipyocyanine (528-71-2) is the virulence factor of Gram-negative, aerobic rod bacterium Pseudomonas aeruginosa. Hemipyocyanine is an α-Amylase inhibitor. |
|
T38137 |
3,5-Dimethylbenzaldehyde
|
|
Endogenous Metabolite
,
Antifungal
|
|
3,5-Dimethylbenzaldehyde has broad-spectrum antimicrobial activity, inhibiting Bacillus subtilis, Pseudomonas albicans, Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Streptococcus pneumoniae. |
|
T38173 |
Propargylcholine
|
Propargylcholine (bromide) |
Antibacterial
|
|
Propargylcholine (Propargylcholine (bromide)) is an alkyne-modified choline analog and inhibits choline catabolism at the level of Dgc enzyme-catalyzed dimethylglycine demethylation in Pseudomonas aeruginosa. |
|
T67912 |
PA3552-IN-1
|
|
|
|
PA3552-IN-1 is an antibiotic adjuvant that can reduce the expression of PA3552 and restore the sensitivity of MDR Pseudomonas aeruginosa DK2 strain to Polymyxin B. |
|
T7495 |
Hexa-D-arginine
|
|
Others
|
|
Hexa-D-arginine is an inhibitor of furin,blocks the activation of Pseudomonas aeruginosa exotoxin A in vivo. |
|
T65309 |
S-Methyl methanesulfonothioate
|
|
Antibacterial
|
|
S-Methyl methanesulfonothioate is a biological raw material with cytotoxicity and potential antimicrobial activity for the study of Pseudomonas aeruginosa infections. |
|
T9119 |
SU0268
|
|
Others
|
|
SU0268 is a potent and specific 8-Oxoguanine DNA glycosylase 1 (OGG1) inhibitor. SU0268 regulates inflammatory responses during Pseudomonas aeruginosa infection. |
|
TP1050L |
Murepavadin acetate(944252-63-5 free base)
|
|
Antibacterial
,
Antibiotic
|
|
Murepavadin acetate is a potent and specific antibiotic for the treatment of bacterial infections cused by Pseudomonas aeruginosa. Murepavadin acetate targets the lipopolysaccharide transport portin D. |
|
T77686 |
1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone
|
|
Antifungal
|
|
1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone has broad-spectrum antifungal activity with inhibitory effects on Candida albicans, Aspergillus niger, Pseudomonas aeruginosa and Staphylococcus aureus. |
|
T4998L |
Cefpodoxime (free acid)
|
|
Others
|
|
Cefpodoxime (free acid) is an oral, third-generation cephalosporin antibiotic. It is active against most Gram-positive and Gram-negative organisms, except Pseudomonas aeruginosa, Enterococcus, and Bacteroides fragilis. |
|
T22269 |
Benzyldodecyldimethylammonium Chloride Dihydrate
|
|
Antibacterial
|
|
Benzyldodecyldimethylammonium chloride dihydrate can be used as an insecticide reagent. It can target drug-resistant bacteria, such as methicillin-resistant Staphylococcus aureus, multidrug-resistant Pseudomonas aerugino... |
|
T23858 |
WCK-5153
|
WCK 5153,WCK5153 |
Antibacterial
|
|
WCK-5153 is an enhancer of β-Lactamase and an inhibitor of PBP2 with antimicrobial activities against Pseudomonas aeruginosa. WCK-5153 can be used in studies about the treatment of serious infections caused by highly dru... |
|
T78226 |
Methyl 2-amino-5-bromobenzoate
|
Methyl 5-Bromoanthranilate |
HCV Protease
,
Antifungal
|
|
Methyl 2-amino-5-bromobenzoate (Methyl 5-Bromoanthranilate) is a hepatitis C virus NS5b RNA polymerase inhibitor with antimicrobial activity that inhibits Pseudomonas aeruginosa infections and is involved in the producti... |
|
T7858 |
Ceftezole sodium
|
Celoslin,Falomesin,Alomen |
Anti-infection
,
Antibacterial
,
Antibiotic
,
Glucosidase
|
|
Ceftezole sodium (Falomesin) is a broad-spectrum cephalosporin antibiotic active gram-negative and gram-positive bacteria except for Proteus vulgaris, Pseudomonas aeruginosa, and Serratia marcescens. It has the inhibitio... |
|
T60247 |
Diethylamine NONOate diethylammonium salt
|
NOC-18 Diethylamine,DEA NONOate diethylamine |
Antibiotic
|
|
Diethylamine NONOate diethylammonium salt (DEA NONOate diethylamine) is a nitric oxide donor with antibacterial activity, a dispersant for preformed biofilms of Pseudomonas aeruginosa and inhibits the growth of E. coli. ... |
|
T124492 |
Imipenem
|
N-Formimidoyl thienamycin,MK0787 |
Antifungal
|
|
Imipenem (MK0787) is a thienomycin derivative that belongs to the class of antibiotics with antibacterial activity and partial inhibition against gram-positive and gram-negative bacteria. Imipenem can be used to study ca... |
|
T13789 |
N-dodecanoyl-L-Homoserine lactone
|
C12-HSL |
Others
|
|
N-dodecanoyl-L-Homoserine lactone (C12-HSL) is a quorum sensing (QS) signaling molecule, a microbial communication mechanism modulated by acyl homoserine lactone (AHL) molecules impacts biofilm formation in bioreactors. |
|
T35449 |
α-(difluoromethyl)-DL-Arginine
|
DFMA,RMI 71897,α-(difluoromethyl)-DL-Arginine |
Others
|
|
α-(difluoromethyl)-DL-Arginine (RMI 71897) is an enzyma-activated, irreversible inhibitor of arginine decarboxylase for E. coli (Ki = 800 μM), Pseudomonas aeruginosa, and Klebsiella pneumoniae. At 0.01 mM, it has been sh... |
|
T33857 |
PA Autoinducer
|
3O-C12 autoinducer,PA-Autoinducer |
|
|
PA Autoinducer is a Pseudomonas aeruginosa autoinducer. |
|
T13788 |
N-Butanoyl-DL-homoserine lactone
|
(Rac)-C4-HSL |
Others
|
|
N-Butanoyl-DL-homoserine lactone aptamers blocks qurom sensing and inhibits biofilm formation in Pseudomonas aeruginosa. |
|
T25136 |
Aztreonam lysine
|
Corus 1020,Corus1020,Corus-1020,Aztreonam lysinate |
|
|
Aztreonam lysine is an inhaled anti-pseudomonal treatment for people who have pulmonary Pseudomonas aeruginosa infection with cystic fibrosis (CF). |
|
T64422 |
Murepavadin
|
|
|
|
Murepavadin is a highly potent, specific, macrocycle Pseudomonas antibiotic for the treatment of bacterial infections caused by Pseudomonas aeruginosa.. |
|
T39983 |
SPR206 acetate
|
|
|
|
SPR206 acetate is a polymyxin analog that exhibits antibiotic activity against Gram-negative pathogens, including multidrug-resistant (MDR) variants. By interacting with the outer membrane of the bacterium, SPR206 acetat... |
|
T39296 |
DS86760016
|
|
|
|
DS86760016 is a highly effective inhibitor of leucyl-tRNA synthetase (LeuRS), demonstrating potent activity against multidrug-resistant (MDR) Gram-negative bacteria including Escherichia coli, Klebsiella pneumoniae, and ... |
|
T15142 |
Vebufloxacin
|
OPC7241,Flumenique,DM8966 |
Antibacterial
|
|
Vebufloxacin (OPC-7251) shows potent antibacterial activity against gram-positive and -negative bacteria, including Staphylococcus aureus and Pseudomonas aeruginosa. It has potent activity characteristically against Prop... |
|
T61368 |
FPI-1602
|
|
|
|
FPI-1602 is a β-lactamase inhibitor with strong antimicrobial activity against Pseudomonas aeruginosa, Escherichia coli, and Enterobacter species [1]. |
|
T77029 |
Gremubamab
|
|
|
|
Gremubamab (MEDI3902), a humanized IgG1 kappa anti-PcrV/Psl monoclonal antibody, specifically targets and binds to the Pseudomonas aeruginosa PcrV protein and Psl exopolysaccharide. It shows promise for the study of Pseu... |
|
T77184 |
Rivabazumab
|
|
|
|
Rivabazumab is a recombinant antibody against Pseudomonas aeruginosa pcrV [1] . |
|
T78537 |
Cefetamet pivoxyl
|
Ro 15-8075 free base |
Antibiotic
|
|
Cefetamet pivoxyl, a cephalosporin antibiotic, effectively inhibits 355 enteropathogens, including Gram-negative bacteria (ausgenommen Pseudomonas aeruginosa) and Legionella pneumophila [1]. |
|
T37912 |
Furanone C-30
|
|
|
|
Synthetic furanone bacterial quorum sensing inhibitor. Inhibits virulence factor expression in Pseudomonas aeruginosa and increases bacterial susceptibility to antibiotics in vitro. Also inhibits bacterial quorum sensing... |
|
T79004 |
ATP synthase inhibitor 2 TFA
|
|
|
|
ATP Synthase Inhibitor 2 (Compound 22) TFA is a potent inhibitor of Pseudomonas aeruginosa ATP synthase with an IC50 value of 10 μg/mL. It effectively halts ATP synthesis in Pseudomonas aeruginosa at a concentration of 1... |
|
T62624 |
LpxA-IN-1
|
|
|
|
LpxA-IN-1, a novel UDP-N-acetylglucosamine acyltransferase (LpxA) inhibitor exhibiting potent activity (IC 50 2 nM), effectively targets Pseudomonas aeruginosa with a minimum inhibitory concentration (MIC) of 8 μg/mL. |
|
T61305 |
LasR-IN-3
|
|
|
|
LasR-IN-3, a chemical compound, acts as an inhibitor of LasR in Pseudomonas aeruginosa. It induces structural instability in LasR and causes complete dissociation of its functioning dimeric form [1]. |
|
T82944 |
ATP Synthesis-IN-2
|
|
|
|
ATP Synthesis-IN-2 (Compound 5) serves as a potent inhibitor of ATP synthesis activity, displaying significant antibacterial properties with an IC50 value of 0.7 μg/mL against Pseudomonas aeruginosa (PA) [1]. |
|
T10944 |
D13-9001
|
|
Others
|
|
The KD values of D13-9001 in Escherichia coli and Pseudomonas aeruginosa were 1.15μM and 3.57μM, respectively. D13-9001 has antibiotic activity. It is an effective AcrB (AcrAB-TolC efflux pump subunit) and MexB (MexAB-Op... |
|
T73531 |
SABA1
|
|
|
|
SABA1 demonstrates antibacterial efficacy against Pseudomonas aeruginosa and Escherichia coli, achieving an IC50 value of 4.0 µM against E. coli ACC. |
|
T61169 |
PqsR-IN-1
|
|
|
|
PqsR-IN-1 (Compound 18) is a potent inhibitor of PqsR, which is a transcriptional regulator involved in the quorum sensing mechanism of Pseudomonas aeruginosa. This compound effectively reduces the production of pyocyani... |
|
T77185 |
Rivabazumab pegol
|
|
|
|
Rivabazumab pegol, a pegylated Fab antibody targeting the PcrV protein, is utilized in phase II studies for chronic Pseudomonas aeruginosa infections [1]. |
|
TP1638 |
OV-1, sheep
|
|
|
|
This alpha-helical antimicrobial OV-1 ovispirin peptide derived from SMAP29 peptide.It was found to inhibit several antibiotic-resistant bacterial strains including mucoid and nonmucoid Pseudomonas aeruginosa. |
|
T68438 |
APO-6619
|
|
|
|
APO-6619 is an iron chelator which was shown to inhibit growth of the following bacterial strains: Acinetobacter baumannii, Pseudomonas aeruginosa, Staphylococcus aureus, Klebsiella pneumoniae, and Escherichia coli. AP... |
|
T61353 |
PqsR-IN-2
|
|
|
|
PqsR-IN-2 (Compound 19) is a highly potent inhibitor of PqsR, the transcriptional regulator responsible for quorum sensing in Pseudomonas aeruginosa. It effectively suppresses pyocyanin production without causing signifi... |
|
T60610 |
LasR-IN-4
|
|
|
|
LasR-IN-4 is a potent inhibitor of LasR which inhibits Pseudomonas aeruginosa and its biofilm formation, pyocyanin production, and rhamnolipids production [1]. |
|
T64315 |
VP-4509
|
|
|
|
VP-4509 is an anti-methicillin-resistant Staphylococcus aureus (MRSA) agent (MIC: 49.3 μM). VP-4509 exhibits high antibacterial activity against the gram-negative bacterium Pseudomonas aeruginosa (ATCC9027). |
|
T80527 |
D-K6L9
|
|
|
|
D-K6L9 exhibits antimicrobial and antibiofilm properties effective against Pseudomonas aeruginosa isolated from patients with cystic fibrosis. The compound demonstrates stability and resistance to degradation by protease... |
|
T78535 |
Trans-Clopenthixol dihydrochloride
|
(E)-Clopenthixol dihydrochloride |
Parasite
|
|
Trans-Clopenthixol dihydrochloride ((E)-Clopenthixol dihydrochloride), an antibiotic without neuroleptic effects, has demonstrated in vitro efficacy against Pseudomonas aeruginosa and Plasmodium falciparum, as referenced... |
|
T61108 |
YXL-13
|
|
|
|
YXL-13 is a highly effective inhibitor of Pseudomonas aeruginosa (PAO1), with an IC50 value of 3.686 μM. It effectively hinders the expression of virulence factors and inhibits biofilm formation in PAO1. Moreover, YXL-13... |
|
T80276 |
Lynronne-3
|
|
|
|
Lynronne-3, an antimicrobial peptide, demonstrates activity against Gram-positive bacteria, including multi-drug resistant (MDR) strains, with a minimum inhibitory concentration (MIC) ranging from 32-128 μg/mL for methic... |
