|
T6948 |
Pluripotin
|
SC1 |
ERK
,
Raf
,
S6 Kinase
|
|
Pluripotin (SC1) (SC1), which keep embryonic stem cell (ESC) self-renewal, is a dual inhibitor of extracellular signal-regulated kinase 1 (ERK1, MAPK3) and RasGAP. |
|
T9743 |
FEN1-IN-SC13
|
|
Others
|
|
FEN1-IN-SC13 is a potent inhibitor of DNA fragmentation endonuclease 1 (FEN1) |
|
T6207 |
SC144
|
|
Apoptosis
,
Interleukin
|
|
SC144 is an orally active small-molecule gp130 inhibitor. |
|
T33750 |
NSC127916
|
NSC 127916,NSC-127916 |
|
|
NSC127916 is a bioactive chemical. |
|
T61177 |
NSC114126
|
|
|
|
NSC114126 is a highly effective and orally bioavailable inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR-TK). This compound exhibits robust antiproliferative properties, making it a... |
|
T12260 |
NSC117079
|
|
Others
|
|
|
|
T81640 |
NSC15520
|
|
|
|
NSC15520, a small-molecule inhibitor of Replication Protein A (RPA), selectively targets the N-terminal DNA binding domain (DBD) of RPA, preventing its interaction with p53 and RAD9. Additionally, NSC15520 impedes the he... |
|
T33752 |
NSC190488
|
|
|
|
NSC190488 is a bioactive chemical. |
|
T68637 |
NSC13987
|
|
|
|
NSC13987 is an inhibitor of Nef-calnexin interaction. |
|
T25884 |
NSC103054
|
NSC-103054,NSC 103054 |
|
|
NSC103054 is an ABCG2 transporter function inhibitor. |
|
T41260 |
SC144 hydrochloride
|
|
|
|
SC144 hydrochloride, a first-in-class, orally active, small-molecule gp130 (IL6-beta) inhibitor, demonstrates potent inhibition of gp130 ligand-triggered signaling. By binding to gp130, it initiates gp130 phosphorylation... |
|
T69141 |
NSC1008
|
|
|
|
NSC1008 is an inhibitor of the Ras Converting Enzyme 1 (Rce1) protease that disrupts Ras membrane localization in human cells. |
|
T24549 |
NSC114792
|
NSC-114792,NSC 114792 |
|
|
NSC114792 is a selective JAK3 inhibitor. |
|
T25885 |
NSC12404
|
CID 224134,CID224134,CID-224134,NSC 12404,NSC-12404 |
|
|
NSC-12404 is a selective non-lipid LPA2/3 agonist. |
|
T33751 |
NSC145021
|
NSC-145021,NSC 145021 |
|
|
NSC145021 is a bioactive chemical. |
|
T16351 |
NSC16168
|
|
Estrogen/progestogen Receptor
|
|
NSC16168 inhibits DNA repair and potentiates CDDP efficacy in cancer. NSC16168 is a specific ERCC1-XPF inhibitor (IC50: 0.42 μM). |
|
T78203 |
NSC194598
|
|
|
|
NSC194598 is a p53 DNA-binding inhibitor, demonstrating an in vitro IC50 of 180 nM and an in vivo range of 2-40 μM. It disrupts the transcriptional activation of the mutated RET gene in human medullary thyroid carcinoma ... |
|
T12114 |
MSC1094308
|
|
p97
|
|
MSC1094308 is a reversible and allosteric inhibitor of the type II AAA ATPase. |
|
T24548 |
NSC10010 hydrochloride
|
NSC#10010,NSC 10010,NSC# 10010,NSC#-10010,NSC-10010 |
|
|
NSC10010 hydrochloride is an effective growth inhibitor for gammaherpesvirus-associated B-lymphomas. It acts through activation of both the NF-κB and c-Myc-mediated signaling pathways. |
|
T28201 |
NSC1011
|
NSC 1011,NSC-1011 |
|
|
NSC1011 is an inhibitor of ras converting enzyme 1 (Rce1). |
|
T69893 |
NSC109131
|
|
|
|
NSC109131 is an inhibitor of human tyrosyl-DNA phosphodiesterase 1 (TDP1). |
|
T28203 |
NSC156529
|
NSC-156529,NSC 156529 |
|
|
NSC156529 downregulates AKT1 signaling. NSC156529 efficiently decreases the proliferation of human cancer cells in vitro, and substantially inhibits the growth of prostate tumor xenografts in vivo. |
|
T33749 |
NSC107392
|
NSC 107392,NSC-107392 |
|
|
NSC107392 is a substrate of ABCG2. |
|
T71527 |
NSC145366
|
|
|
|
NSC145366 is an inhibitor of Hsp90 activities which targets the Hsp90 C-terminal domain to induce allosteric inhibition and selective client downregulation. NSC145366 increases Hsp90 oligomerization resulting in alloster... |
|
T62722 |
SC13
|
|
|
|
SC13, a novel mitragynine analog, exhibits low-efficacy agonism at Mu opioid receptors and provides antinociception while minimizing adverse effects. |
|
T60095 |
CCF0058981
|
|
SARS-CoV
|
|
CCF0058981 (CCF981) is a 3-chlorophenyl analogue, serving as a noncovalent inhibitor of SARS-CoV-2 3CL pro (SC2), demonstrating potent activity with an IC50 of 68 nM. It also exhibits inhibitory effects against SARS-CoV-... |
