|
T7133 |
Anagliptin
|
SK-0403 |
Proteasome
,
DPP-4
|
|
Anagliptin (SK-0403) is a potent Inhibitor of DPP-4(IC50 of 3.8 nM), for the treatment of type 2 diabetes mellitus. |
|
T9116 |
SMCC
|
N-Succinimidyl 4-(N-maleimidomethyl)cycl |
Others
|
|
SMCC (N-Succinimidyl 4-(N-maleimidomethyl)cycl) is a heterobifunctional protein crosslinker. |
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T16899 |
SMCC-DM1
|
DM1-SMCC |
Others
|
|
SMCC-DM1 (DM1-SMCC) (DM1-SMCC) is a drug-linker conjugate which composed of a potent microtubule-disrupting agent DM1 and a linker SMCC to make antibody-drug conjugate (ADC). |
|
T11917 |
Lys-SMCC-DM1
|
Lys-Nε-MCC-DM1 |
Microtubule Associated
|
|
DM1 is a tubulin inhibitor. Lys-SMCC-DM1 (Lys-Nε-MCC-DM1) is the active metabolite of DM1. |
|
T18728 |
Sulfo-SMCC sodium
|
|
Others
|
|
Sulfo-SMCC sodium, a widely utilized non-cleavable, hetero-bifunctional crosslinker for antibody-drug conjugates (ADCs), features both N-hydroxysuccinimide (NHS) ester and maleimide groups. These functionalities enable i... |
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T17833 |
DM4-SMCC
|
|
Others
|
|
DM4-SMCC, a non-cleavable drug-linker conjugate for antibody-drug conjugates (ADC), leverages the antitumor efficacy of DM4 (an antitubulin agent) through attachment with the SMCC linker, exhibiting antitumor activity[1]... |
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T18856 |
Trans-Sulfo-SMCC
|
|
Others
|
|
trans-Sulfo-SMCC is a non-cleavable and membrane permeable ADC crosslinker. |
|
T15161 |
Doxorubicin-SMCC
|
|
Others
|
|
Doxorubicin-SMCC is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. |
|
T63090 |
SMCypI C31
|
|
|
|
SMCypIC31 is a non-peptide cyclophilin inhibitor that effectively inhibits peptidyl-prolyl cis/trans isomerase (PPIase) (IC50: 0.1 μM). SMCypI C31 has a pan-genotypic effect against HCV, with an EC50 range of 1.20-7.76 μ... |
|
T33865 |
Palbociclib-SMCC
|
PD0332991-SMCC,Palbociclib-SMCC linker,PD 0332991-SMCC,PD-0332991-SMCC |
|
|
Palbociclib-SMCC is a Palbociclib derivative with a SMCC linker. |
|
TP1639 |
Smcy HY Peptide (738-746)
|
Smcy HY Peptide 738-746 |
|
|
Smcy HY Peptide (738-746) is an H2-Db-restricted peptide, derived from the amino acid sequence 738 to 746 of the Smcy protein. |
|
T18361 |
MMAE-SMCC
|
|
Others
|
|
MMAE-SMCC is a drug-linker conjugate designed for antibody-drug conjugates (ADC). It consists of MMAE, a potent inhibitor of mitosis and tubulin, and SMCC, a linker that facilitates the development of ADCs. |
|
T28289 |
Paclitaxel-SMCC
|
SMCC taxol, Taxol-SMCC, Taxol SMCC,Paclitaxel with SMCC linker,SMCC-Taxol,Paclitaxel ADC conjugate. |
|
|
Paclitaxel-SMCC is a paclitaxel derivative with a SMCC linker. (Succinimidyl-4-( N -maleimidomethyl)cyclohexane-1-carboxylate). Paclitaxel-SMCC can be used to synthesize Paclitaxel bioconjugates with enzymes, antobodies,... |
|
T81280 |
Rha-PEG3-SMCC
|
|
|
|
Rha-PEG3-SMCC (Compound 13) serves as an ADC (antibody-drug conjugate) linkage agent with robust antitumor properties, utilizing the protein crosslinker SMCC, which is tethered through the non-cleavable linker Rha-PEG3. |
|
T72050 |
4-N-Dodecyloxyphenol
|
4-dodecoxyphenol,p-Dodecyloxyphenol |
|
|
4-N-Dodecyloxyphenol (p-Dodecyloxyphenol) is a compound that can be used as an additive to ferroelectric or ferroelectric liquid crystals or to display the SmC phase and has no chiral groups. |
|
T20765 |
Atorvastatin
|
|
HMG-CoA Reductase
,
Autophagy
|
|
Atorvastatin is an orally active HMG-CoA reductase inhibitor that has the ability to effectively lower blood lipids by activating liver cytochrome p450 to accelerate metabolism. Atorvastatin inhibited proliferation and i... |
|
T3116 |
Atorvastatin hemicalcium salt
|
Lipitor,Atorvastatin hemicalcium,Atorvastatin Calcium,CI-981,Sortis |
Ferroptosis
,
HMG-CoA Reductase
,
Autophagy
|
|
Atorvastatin hemicalcium salt (Atorvastatin Calcium), an effective HMG-CoA reductase inhibitor (IC50 = 8 nM), is utilized as a cholesterol-lowering medication. |
|
T6265 |
Bosentan (hydrate)
|
Bosentan Hydrate,Benzenesulfonamide,Actelion,Ro 47-0203 |
Endothelin Receptor
|
|
Bosentan hydrate (Ro 47-0203) is a competitive and dual antagonist of endothelin-1 at the endothelin-A (ET-A) and endothelin-B (ET-B) receptors. |
|
TP1016L |
Aviptadil Acetate
|
Vasoactive Intestinal Peptide acetate salt |
RAAS
,
SARS-CoV
|
|
Aviptadil Acetate (Vasoactive Intestinal Peptide acetate salt) induces pulmonary vasodilation and inhibits the proliferation of vascular SMCs and platelet aggregation. Avitadil acetate can be used for research on pulmona... |
|
T6264 |
Bosentan
|
Actelion,Ro 47-0203,Benzenesulfonamide |
Endothelin Receptor
|
|
Bosentan (Benzenesulfonamide) is a sulfonamide-derived, competitive and specific endothelin receptor antagonist with a slightly higher affinity for the endothelin A receptor than endothelin B receptor. Bosentan blocks th... |
|
T73820 |
Bosentan-d4
|
|
|
|
Bosentan-d4, the deuterium-labeled variant of Bosentan, serves as a competitive dual antagonist against endothelin-1 (ET) by targeting both ET A and ET B receptors. It exhibits binding affinities with K i values of 4.7 n... |
|
T15127 |
Difluoro atorvastatin
|
Fluoroatorvastatin |
Others
|
|
Difluoro atorvastatin is an Atorvastatin impurity. Atorvastatin is an orally active HMG-CoA reductase inhibitor and it has the ability to effectively decrease blood lipids. Atorvastatin inhibits human SV-SMC proliferatio... |
|
T72101 |
Atorvastatin hemicalcium trihydrate
|
|
|
|
Atorvastatin Hemicalcium Trihydrate, an orally active HMG-CoA reductase inhibitor, effectively reduces blood lipids. It also inhibits human SV-SMC proliferation and invasion, showing IC50 values of 0.39 μM and 2.39 μM, r... |
|
T60412 |
BPN-15477
|
|
|
|
BPN-15477 is a splicing modulator compound (SMC) that restores the correct splicing of ELP1 exon 20. It can be used for frontotemporal dementia research. BPN-15477 corrects the splicing of the ELP1 transcript which signi... |
|
T67442 |
CGP-53716
|
|
|
|
The growth factors, platelet-derived growth factor (PDGF) and basic fibroblast growth factor (bFGF) play major roles in enhanced smooth muscle cells growth in rodent blood vessels after vascular injury. Tyrosine kinase i... |
