JAK

The JAK-STAT signalling pathway is a chain of interactions between proteins in a cell, and is involved in processes such as immunity, cell division, cell death and tumour formation. There are 4 JAK proteins: JAK1, JAK2, JAK3 and TYK2. JAKs contains a FERM domain (approximately 400 residues), an SH2-related domain (approximately 100 residues), a kinase domain (approximately 250 residues) and a pseudokinase domain (approximately 300 residues). The kinase domain is vital for JAK activity, since it allows JAKs to phosphorylate (add phosphate groups to) proteins.

Cat. No.	製品名	CAS No.	Purity
T6020	Pacritinib	937272-79-2	98%
T6020	Pacritinib (SB1518) is an effective and specific inhibitor of JAK2 and FLT3 (IC50: 23/22 nM, in cell-free assays).
T6914	Oclacitinib maleate	1640292-55-2	98%
T6914	Oclacitinib is a novel inhibitor of JAK family members with IC50 ranging from 10 to 99 nM and JAK1-dependent cytokines with IC50 ranging from 36 to 249 nM, which...
TQ0010	Brepocitinib	1883299-62-4	98%
TQ0010	PF-06700841 is a potent dual JAK1/TYK2 inhibitor (IC50s: 17 nM/23 nM). It also inhibits JAK2/3 (IC50s: 77 nM/6.49 μM).
T2S1040	Jolkinolide B	37905-08-1	98%
T2S1040	Jolkinolide B is a bioactive diterpene isolated from the roots of Euphorbia fischeriana Steud. Jolkinolide B induces apoptosis in cancer cells. Jolkinolide B can...
T1995	Fedratinib	936091-26-8	98%
T1995	Fedratinib (TG101348) is an ATP-competitive inhibitor of JAK2 (IC50: 3 nM) with significantly less potent activity against JAK3.
T2S1975	Ponicidin	52617-37-5	98%
T2S1975	Ponicidin has anti-leukemia, immunoregulatory and anti-inflammatory functions, it also has anti-viral function especially in the upper respiratory tract infectio...
T35900	JAK2-IN-7	2593402-36-7	98%
T35900	JAK2-IN-7 is a selective JAK2 inhibitor with IC 50 s of 3, 11.7, and 41 nM for JAK2, SET-2, and Ba/F3 V617F cells, respectively. JAK2-IN-7 possesses over 14-fold...
T9251	Fedratinib hydrochloride hydrate	1374744-69-0	98%
T9251	Fedratinib hydrochloride hydrate is a potent, selective, ATP-competitive and orally active JAK2 inhibitor.
T61494	JAK-IN-21	2445499-20-5	98%
T61494	JAK-IN-21 is a selective and potent JAK inhibitor that inhibits JAK1, JAK2, J2V617F and TYK2 with IC50 values of 1.73, 2.04, 109 and 62.9 nM, respectively.
T5S0993	Kurarinone	34981-26-5	98%
T5S0993	Kurarinone, a flavanoid derived from shrub Sophora flavescens,Kurarinone exhibits anti-tumor, estrogenic, and anti-inflammatory activities, it also shows strong ...
T12266L	Ilginatinib maleate	1354799-87-3	98%
T12266L	Ilginatinib maleate is a highly active and orally bioavailable inhibitor of JAK2.
T4227	SB1317 hydrochloride (1204918-72-8(free base))	T4227	98%
T4227	SB1317 is an effective inhibitor of CDK2/JAK2/FLT3 (IC50: 13/73/56 nM).
T17019	TCS 21311	1260181-14-3	98%
T17019	TCS 21311 is an effective and highly selective inhibitor of JAK3 (IC50: 8 nM). TCS 21311 inhibits PKCα, PKCθ, and GSK3β (IC50s: 13, 68, and 3 nM, respectively)....
T67907	Nimucitinib	2740557-24-6	98%
T67907	Nimucitinib is a Janus kinase (JAK) inhibitor that can be used to treat dry eye and promote tear production.
T4657	WHI-P97	211555-05-4	98%
T4657	WHI-P97 is a rationally designed potent inhibitor of JAK-3. IC50 value: Target: JAK3 Treatment of mast cells with WHI-P97 inhibited the translocation of 5-lipoxy...
T3042	NSC 42834	195371-52-9	98%
T3042	NSC 42834(JAK2 Inhibitor V, Z3) is a novel specific inhibitor of Jak2, inhibiting Jak2-V617F and Jak2-WT autophosphorylation in a dose-dependent manner.
T9826	GDC-0214	1831144-46-7	98%
T9826	GDC-0214 is an inhaled small-molecule JAK1 inhibitor and reduces fractional exhaled nitric oxide (Feno).
T2398	Tofacitinib Citrate	540737-29-9	98%
T2398	Tofacitinib citrate is a a potent, cell-permeable inhibitor of JAK1/2/3 (IC50s: 1/20/112 nM).
T5091	FM-381	2226521-65-7	98%
T5091	FM381 is a potent covalent reversible inhibitor of JAK3. FM-381 has an IC50 of 127 pM for JAK3, with 410, 2700 and 3600-fold selectivity over JAK1, JAK2 and TYK2...
T40443	JAK2-IN-6	353512-04-6	98%
T40443	JAK2-IN-6, a polysubstituted aminothiazole derivative, is a potent and selective inhibitor of JAK2 (ic50 at 22.86 μg/mL). Jak2-in-6 inhibits the activity of JAK2...