|
T62164 |
TNK2-IN-1
|
|
|
|
TNK2-IN-1 is a TNK2 inhibitor (IC50: 224 nM) that can be used in cancer research. |
|
T5092 |
AIM-100
|
AIM100 |
ACK
|
|
AIM-100 is a Ack1 inhibitor (IC50: 24 nM). |
|
T3196 |
GNF-7
|
GNF7 |
Bcr-Abl
,
ACK
,
AChR
|
|
GNF-7 is Bcr-Abl WT and Bcr-Abl T315I inhibitor with IC50 of 133 nM and 61 nM, respectively. |
|
T2641 |
KRCA-0008
|
KRCA 0008,KRCA0008 |
ACK
,
ALK
|
|
KRCA-0008 is an effective and specific ALK/Ack1 inhibitor (IC50: 12/4 nM); displays drug-like properties without hERG liability. |
|
T3710 |
XMD16-5
|
|
Tyrosinase
,
PPAR
|
|
XMD16-5 is a TNK2 inhibitor. TNK2 genomic amplification has been associated with late-stage or metastatic lung and prostate Ys. Overexpression of TNK2 promoted metastasis in a mouse model of breast Y. TNK2 signaling is d... |
|
T3709 |
XMD8-87
|
ACK1-B19 |
Tyrosinase
,
PPAR
|
|
XMD8-87 (ACK1-B19) is a TNK2 inhibitor with activity in the inhibition of TNK2 phosphorylation. XMD8-87 and XMD16-5 potently inhibit phosphorylation of TNK2 truncation mutations found in solid tumor types. |
|
T3630 |
Relugolix
|
RVT-601,TAK-385 |
GNRH Receptor
|
|
Relugolix (RVT-601) is an orally available, non-peptide gonadotropin-releasing hormone (GnRH or luteinizing hormone-releasing hormone (LHRH)) antagonist, with potential antineoplastic activity. Relugolix competitively bi... |
|
T74642 |
DB1113
|
|
|
|
DB1113 (Example 24) is a bifunctional compound designed for the targeted degradation of various kinases. It effectively degrades a range of kinases, including ABL1, ABL2, BLK, CDK11B, CDK4, CSK, EPHA3, FER, GAK, LIMK1, M... |
|
T82385 |
FMF-06-098-1
|
|
PROTACs
|
|
FMF-06-098-1 is a multitargeted depressant capable of promoting the degradation of a wide array of kinases, including AAK1, ABL2, AURKA, AURKB, BUB1B, CDC7, CDK1, CDK12, CDK13, CDK2, CDK4, CDK6, CDK7, CDK9, CHEK1, CSNK1D... |
|
T74644 |
DB0614
|
|
|
|
DB0614 (Example 21) is a bifunctional compound designed for the targeted degradation of kinases, effectively breaking down a wide array of kinases including AAK1, AURKA, BMP2K, CAMKK1, CDK16, CML, CDK6, EIF2AK2, FER, GAK... |
|
T12102 |
Mps1-IN-1
|
|
Others
|
|
Mps1-IN-1 is a potent, selective and ATP-competitive inhibitor of Mps1 kinase (IC50 : 367 nM ) |
