Powder: -20°C for 3 years | In solvent: -80°C for 1 year
AIM-100 is a Ack1 inhibitor (IC50: 24 nM).
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
2 mg | 在庫あり | ¥ 10,000 | |||
5 mg | 在庫あり | ¥ 16,000 | |||
10 mg | 在庫あり | ¥ 24,000 | |||
25 mg | 在庫あり | ¥ 50,000 | |||
50 mg | 在庫あり | ¥ 87,000 | |||
100 mg | 在庫あり | ¥ 137,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 22,500 |
説明 | AIM-100 is a Ack1 inhibitor (IC50: 24 nM). |
ターゲット&IC50 | Ack1:24 nM |
In vitro | AIM-100 not only inhibited Ack1 activation but also suppressed AKT tyrosine phosphorylation, leading to cell cycle arrest in the G1 phase [1]. It also was able to suppress AR Tyr(267) phosphorylation and its recruitment to the ATM enhancer. Notably, AIM-100 suppressed Ack1 mediated ATM expression and mitigated the growth of radioresistant CRPC tumors [2]. AIM-100, not only inhibited Ack1 activation but also able to suppress pTyr267-AR phosphorylation, binding of AR to PSA, NKX3.1, and TMPRSS2 promoters, and inhibit AR transcription activity [3]. |
別名 | AIM100 |
分子量 | 371.43 |
分子式 | C23H21N3O2 |
CAS No. | 873305-35-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 60 mg/mL (161.54 mM)
Ethanol: 30 mg/mL
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
AIM-100 873305-35-2 Tyrosine Kinase/Adaptors ACK TMPRSS2 Inhibitor Ack1 NKX3.1 TNK2 ATM Activated Cdc42 kinase 1 Tyr-phosphorylation PSA AIM100 Tyr267 inhibit anticancer AIM 100 inhibitor