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T10247 |
Adenosine 5'-diphosphoribose sodium
|
Adenosine 5'-diphosphoribose sodium,ADP ribose sodium |
Endogenous Metabolite
,
TRP/TRPV Channel
,
Autophagy
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T2007 |
RQ-00203078
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|
TRP/TRPV Channel
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RQ-00203078 is a highly selective, potent and orally available TRPM8 antagonist. |
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T16532 |
Pico145
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HC-608 |
TRP/TRPV Channel
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Pico145 (HC-608) is a remarkable inhibitor of TRPC1/4/5 channels. Pico145 inhibits ( )-englerin A-activated TRPC4/TRPC5 channels (IC50s: 0.349 and 1.3 nM in cells) It also shows no effect on TRPC3, TRPC6, TRPV1, TRPV4, T... |
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T9263 |
Cim0216
|
N-(5-methyl-1,2-oxazol-3-yl)-2-phenyl-2-(1,2,3,4-tetrahydroquinolin-1-yl)acetamide |
TRP/TRPV Channel
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CIM0216 is a synthetic TRPM3 activator whose potency and apparent affinity greatly exceeds that of the canonical TRPM3 agonist. |
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T1622 |
Rosiglitazone maleate
|
BRL 49653C,BRL 49653 |
Ferroptosis
,
TRP/TRPV Channel
,
PPAR
,
Autophagy
|
|
Rosiglitazone maleate (BRL 49653) is the maleate salt of rosiglitazone, an orally-active thiazolidinedione with antidiabetic properties and potential antineoplastic activity. |
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T80506 |
TAT-M2NX
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tatM2NX |
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TAT-M2NX (tatM2NX) is a selective TRPM2 inhibitor that exhibits neuroprotective effects in male mice. It is utilized in research to investigate ischemic neuronal injury [1]. |
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T73755 |
Farnesyl pyrophosphate
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Farnesyl pyrophosphate (Farnesyl diphosphate), a 15-carbon isoprenoid derived from the mevalonate (MVA) pathway, acts as a metabolic intermediary. It serves as a TRPM2 (TRP Channel) agonist, facilitating the opening of T... |
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T78081 |
Farnesyl Pyrophosphate ammonium
|
Farnesyl diphosphate ammonium |
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Farnesyl Pyrophosphate Ammonium Salt, a 15-carbon isoprenoid derived from the mevalonate (MVA) pathway, functions as a TRPM2 (TRP Channel) agonist, facilitating the opening of TRPM2 channels for ion influx. It serves as ... |
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T74779 |
JNJ-28583113
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|
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JNJ-28583113, a TRPM2 antagonist with brain permeability, inhibits the phosphorylation of GSK3α and β subunits, thereby protecting cells from oxidative stress-induced cell death. Additionally, it suppresses cytokine rele... |
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T37475 |
Cyclic ADP-Ribose (ammonium salt)
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cADP-Ribose,cADPR,Cyclic ADP-Ribose (ammonium salt) |
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Cyclic ADP-ribose (cADP-ribose) is an endogenous metabolite of NAD+ that mobilizes the release of stored Ca2+ in the endoplasmic reticulum via ryanodine receptors in various cell types.[1],[2],[3],[4],[5] This second mes... |
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T83730 |
Tat-M2NX TFA
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Tat-M2NX, a peptide antagonist of transient receptor potential melastatin 2 (TRPM2), blocks hydrogen peroxide-induced calcium influx in HEK293 cells expressing human TRPM2 at concentrations between 25 to 100 µM. In male ... |
