Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Pico145 (HC-608) is a remarkable inhibitor of TRPC1/4/5 channels. Pico145 inhibits ( )-englerin A-activated TRPC4/TRPC5 channels (IC50s: 0.349 and 1.3 nM in cells) It also shows no effect on TRPC3, TRPC6, TRPV1, TRPV4, TRPA1, TRPM2, TRPM8.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 27,000 | |||
5 mg | 在庫あり | ¥ 67,000 | |||
10 mg | 在庫あり | ¥ 105,000 | |||
25 mg | 在庫あり | ¥ 173,000 | |||
50 mg | 在庫あり | ¥ 243,500 | |||
100 mg | 在庫あり | ¥ 328,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 76,500 |
説明 | Pico145 (HC-608) is a remarkable inhibitor of TRPC1/4/5 channels. Pico145 inhibits ( )-englerin A-activated TRPC4/TRPC5 channels (IC50s: 0.349 and 1.3 nM in cells) It also shows no effect on TRPC3, TRPC6, TRPV1, TRPV4, TRPA1, TRPM2, TRPM8. |
ターゲット&IC50 | TRPC4:0.349 nM (cell assay), TRPC5:1.3 nM (cell assay), TRPC4-TRPC1:0.03 nM (cell assay), TRPC5-TRPC1:0.2 nM (cell assay) |
In vitro | Pico145 is a remarkable small-molecule inhibitor of TRPC1/4/5 channels. Pico145 displays no effect on TRPC3, TRPC6, TRPV1, TRPV4, TRPA1, TRPM2, TRPM8. Pico145 inhibits (?)-englerin A-activated TRPC4/TRPC5 channels (IC50s: 0.349 and 1.3 nM in cells). Pico145 also inhibits human TRPC4-TRPC1 and TRPC5-TRPC1 concatemers expressed in HEK 293 Tet+ cells (IC50, 0.03 nM, and 0.2 nM, respectively). Pico145 effectively inhibits RPC4-TRPC1 channels activated by sphingosine 1-phosphate (S1P) and suppresses S1P-evoked Ca2+ entry through TRPC4-TRPC1 channels (IC50: 0.011 nM). The potency of Pico145 can be reduced by increased (?)-englerin A concentration. Pico145 also sensitizes EA-sensitive cancer cell line (Hs578T cells) (IC50, 0.11 nM). Pico145 (100 nM) lacks effect on store-operated Ca2+ entry and histamine-evoked Ca2+ entry into endothelial cells[1]. |
別名 | HC-608 |
分子量 | 524.88 |
分子式 | C23H20ClF3N4O5 |
CAS No. | 1628287-16-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 99 mg/mL (188.61 mM)
You can also refer to dose conversion for different animals. 詳細
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Pico145 1628287-16-0 Membrane transporter/Ion channel TRP/TRPV Channel TRP Channel Transient receptor potential channels inhibit HC608 Pico-145 Inhibitor HC 608 Pico 145 HC-608 inhibitor