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Search Results for " Tpo "

ターゲット

阻害剤

天然化合物

リコンビナントタンパク質

カタログ番号	製品名	別名	ターゲット
T17146	TPO agonist 1		Others
	TPO agonist 1 is a thrombopoietin agonist. It would be useful as promoters of thrombopoiesis and megakaryocytopoiesis to treat thrombocytopenia.		Others
T2562	Eltrombopag	SB-497115,SB-497115-GR	Thrombin
	Eltrombopag (SB-497115-GR), an orally active thrombopoietin receptor agonist with megakaryopoiesis stimulating activity, binds to and stimulates the platelet thrombopoietin receptor (TPO-R or CD110).		Thrombin
T6825	Eltrombopag Olamine	Promacta Olamine,Revolade,Eltrombopag diethanolamine salt,SB497115,SB-497115GR	Thrombin
	Eltrombopag Olamine (Eltrombopag diethanolamine salt) is the orally active ethanolamine salt of eltrombopag, a small-molecule, nonpeptide thrombopoietin receptor agonist with megakaryopoiesis-stimulating activity. Eltrom...		Thrombin
T7417	Avatrombopag	YM477,AKR-501,E5501	Thrombin , Thrombopoietin Receptor
	Avatrombopag (YM477) is a new oral thrombopoietin (TPO) receptor agonist, activating TPO receptor and increasing megakaryocytic proliferation/differentiation and platelet production.		Thrombin , Thrombopoietin Receptor
T3473	(S)-ATPO	ATPO	GluR
	(S)-ATPO is Competitive antagonist at GluR1-4 (AMPA-preferring) receptors.		GluR
T17147	TPOP146		Epigenetic Reader Domain
	TPOP146 is a selective CBP/P300 benzoxazepine bromodomain inhibitor (Kd: 134 nM and 5.02 μM for CBP and BRD4).		Epigenetic Reader Domain
TQ0223	Lusutrombopag	S-888711,Mulpleta	Thrombin , Thrombopoietin Receptor
	Lusutrombopag (Mulpleta) is an orally bioavailable, small molecule thrombopoietin (TPO) receptor agonist for chronic liver disease (CLD) patients with thrombocytopenia prior to elective invasive surgery.		Thrombin , Thrombopoietin Receptor
T67894	Butyzamide		Thrombopoietin Receptor , JAK
	Butyzamide is an effective and oral Mpl activator. It is a novel non-peptide-based molecule with antagonistic effects on thrombopoietin (TPO) receptors, which promotes proliferation of human Mpl (hMpl) expression and mou...		Thrombopoietin Receptor , JAK
T68560	Totrombopag choline
	Totrombopag, also known LGD-4665, GSK2285921 and SB559448, is an oral thromobopoietin receptor agonist, is being developed as a new generation small molecule thrombopoietin (TPO) mimetic. It is a highly selective and po...
T40654	Avatrombopag hydrochloride	AKR-501 hydrochloride,YM477hydrochloride,E5501hydrochloride
	Avatrombopag hydrochloride (AKR-501) is an orally active, nonpeptide agonist of the thrombopoietin (TPO) receptor with an EC 50 of 3.3 nM. It effectively mimics the biological activities of TPO, stimulating platelet prod...
T27536	Hetrombopag olamine
	Hetrombopag olamine is a non-peptide thrombopoietin (TPO) receptor agonist with oral activity.
T62865	Rafutrombopag
	Rafutrombopag is a thrombopoietin (TPO) agonist.
TMIH-0102	Avatrombopag-d8
	Avatrombopag-d8 is a deuterated compound of Avatrombopag. Avatrombopag has a CAS number of 570406-98-3. Avatrombopag is a new oral thrombopoietin (TPO) receptor agonist, activating TPO receptor and increasing megakaryocy...
T68888	Avatrombopag maleate
	Avatrombopag, also known as AKR-501, YM477, AS 1670542 or E5501, is a novel orally-active thrombopoietin (TPO) receptor agonist. AKR-501 specifically targeted the TPO receptor and stimulated megakaryocytopoiesis througho...
T60281	MPO-IN-4
	MPO-IN-4 (compound 12) is a potent and selective myeloperoxidase (MPO) inhibitor with an IC 50 of 25 nM. MPO-IN-4 also demonstrates inhibition of thyroid peroxidase (TPO) with IC50 of 2.2 μM. MPO-IN-4 has no effect on me...
T38602	(E/Z)-Eltrombopag 13C4	(E/Z)-Eltrombopag 13C4,(E/Z)-SB-497115 13C4
	(E/Z)-Eltrombopag 13C4 ((E/Z)-SB-497115 13C4) is a mixture complex of E-Eltrombopag and Z-Eltrombopag, with 13C labeled. Z-Eltrombopag is a thrombopoietin (TPO) receptor agonist developed for certain conditions that lead...
T72265	Eltrombopag methyl ester
	Eltrombopag Methyl Ester, a derivative of Eltrombopag, functions as a thrombopoietin (Tpo) receptor agonist to enhance platelet production and is employed in the study of certain thrombocytopenia variants.
T40137	MPO-IN-1
	MPO-IN-1 is a powerful and orally bioavailable indole-containing inhibitor that acts irrevocably on myeloperoxidase (MPO). With IC50 values of 2.6 μM and 5.3 μM for MPO and thyroid peroxidase (TPO), respectively, MPO-IN-...

Compounds

Synonym: SB-497115,SB-497115-GR

Target: Thrombin

Eltrombopag Olamine

T6825

Synonym: Promacta Olamine,Revolade,Eltrombopag diethanolamine salt,SB497115,SB-497115GR

Target: Thrombin

Avatrombopag

T7417

Synonym: YM477,AKR-501,E5501

Target: Thrombin, Thrombopoietin Receptor

Target: Epigenetic Reader Domain

Lusutrombopag

TQ0223

Synonym: S-888711,Mulpleta

Target: Thrombin, Thrombopoietin Receptor

Butyzamide

T67894

Synonym:

Target: Thrombopoietin Receptor, JAK

Avatrombopag hydrochloride

T40654

Synonym: AKR-501 hydrochloride,YM477hydrochloride,E5501hydrochloride

(E/Z)-Eltrombopag 13C4

T38602

Synonym: (E/Z)-Eltrombopag 13C4,(E/Z)-SB-497115 13C4

Target:

Eltrombopag methyl ester

カタログ番号	製品名	別名	ターゲット
T3882	4”-O-Glucosylvitexin	glucosylvitexin	Thrombopoietin Receptor
	4”-O-Glucosylvitexin (glucosylvitexin) inhibits TPO activity.		Thrombopoietin Receptor

天然物製品

4”-O-Glucosylvitexin

T3882

Synonym: glucosylvitexin

Target: Thrombopoietin Receptor

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPJ-00235	TPO Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Thrombopoietin (TPO) is a glycoprotein hormone which belongs to the EPO/TPO family. It produced by the liver and kidney which regulates the production of platelets. TPO stimulates the production and differentiation of me...
TMPY-00939	Thrombopoietin Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	Thrombopoietin Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 37 kDa and the accession number is P40226-1.
TMPK-00940	C-MPL Protein, Mouse, Recombinant (aa 26-482, His)	Mouse	HEK293 Cells
	C-MPL Protein, Mouse, Recombinant (aa 26-482, His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 52.3 kDa and the accession number is Q08351-1.
TMPY-04201	Thrombopoietin Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	Thrombopoietin Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 45 kDa and the accession number is P40225-1.
TMPK-00877	C-MPL Protein, Human, Recombinant (aa 26-491, His)	Human	HEK293 Cells
	C-MPL Protein, Human, Recombinant (aa 26-491, His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 53.6 kDa and the accession number is P40238-1.
TMPK-00494	C-MPL Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293 Cells
	C-MPL Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 53.48 kDa and the accession number is A0A2K5UGC7.
TMPY-06863	C-MPL Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	C-MPL Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 52.64 kDa and the accession number is Q08351-1.
TMPK-00874	Thyroid Peroxidase Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	Thyroid peroxidase, also called thyroperoxidase (TPO) or iodide peroxidase that encodes a 933 amino-acid residue (aa) molecule with a single membrane-spanning region. Thyroid peroxidase plays a key role in thyroid hormon...
TMPJ-00071	EPO/Erythropoietin Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Erythropoietin (EPO) is a glycoprotein hormone that is principally known for its role in erythropoiesis, where it is responsible for stimulating proliferation and differentiation of erythroid progenitor cells. Erythropoi...