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T11723L |
JNJ-39758979
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Histamine Receptor
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JNJ-39758979 is a selective and high-affinity histamine H4 receptor antagonist (Kis: 12.5, 5.3, and 25 nM for human, mouse, and monkey histamine H4 receptor, respectively). JNJ-39758979 functionally antagonizes histamine... |
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T22746 |
Tesmilifene fumarate
|
DPPE fumarate |
Histamine Receptor
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|
Tesmilifene fumarate (DPPE fumarate) (DPPE fumarate) is an H1C receptor antagonist。 |
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T0797 |
Cimetidine
|
SKF-92334 |
Histamine Receptor
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Cimetidine (SKF-92334) is a histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEP... |
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T1336 |
Benztropine mesylate
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Benzotropine mesylate,Benzatropine mesylate,Benztropine methanesulfonate |
Dopamine Receptor
,
AChR
,
Histamine Receptor
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|
Benztropine mesylate (Benztropine methanesulfonate) is a centrally active muscarinic antagonist that has been used in the symptomatic treatment of PARKINSON DISEASE. Benztropine also inhibits the uptake of dopamine. |
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T26253 |
Tecastemizole
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Norastemizole,R-43512,R43512,R 43512,T 1348 |
Histamine Receptor
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Tecastemizole (R 43512) is a selective antagonist of H1 receptor and a major metabolite of astemizole with anti-inflammatory effects. |
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T6426 |
Buclizine dihydrochloride
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Longifene,Buclina,Buclizine HCl,UCB-4445 |
5-HT Receptor
,
AChR
,
Histamine Receptor
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Buclizine dihydrochloride (Buclina) is the hydrochloride salt form of buclizine, a piperazine histamine H1 receptor antagonist with primarily antiemetic and antivertigo activities. Buclizine dihydrochloride binds to and ... |
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T1110 |
Meclizine dihydrochloride
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Meclozine dihydrochloride,NSC28728,Meclizine 2HCl |
Apoptosis
,
Histamine Receptor
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Meclizine dihydrochloride (NSC28728) is a histamine H1 antagonist used in the treatment of motion sickness, vertigo, and nausea during pregnancy and radiation sickness. |
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T1090 |
Perphenazine
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Perphenazin,Etaperazine,Trilafon |
CaMK
,
Dopamine Receptor
,
5-HT Receptor
,
Adrenergic Receptor
,
Histamine Receptor
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Perphenazine (Trilafon) is a phenothiazine derivative and a dopamine antagonist with antiemetic and antipsychotic properties. |
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T0147 |
Clemastine fumarate
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HS-592 (fumarate),Meclastine fumarate,Meclastine (fumarate) |
Autophagy
,
Histamine Receptor
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Clemastine fumarate (Meclastine (fumarate)) is a synthetic ethanolamine with anticholinergic, sedative, and histamine H1 antagonistic properties. |
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T27159 |
DF-1111301
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DF1111301,DF 1111301 |
Platelet aggregation
,
Histamine Receptor
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DF-1111301 is a novel anti-allergic compound with anti-histamine H1 and anti-PAF activity. |
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T10945 |
D18024
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Others
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D18024 is a phthalazinonderivat with anti-allergic and anti-histamine effect. |
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T0298 |
Dimenhydrinate
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Dramamine,Chloranautine,Vomex A |
Histamine Receptor
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Dimenhydrinate (Vomex A) is an ethanolamine and histamine antagonist with anti-allergic activity. |
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T3979 |
Emedastine
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LY188695,Emadine |
Histamine Receptor
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|
Emedastine (LY188695) is a second generation, selective histamine H1 receptor antagonist with anti-allergic activity. Emedastine reversibly and competitively blocks histamine by binding to H1 receptors, thus blocking its... |
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T34709 |
ST-1006
|
ST 1006 |
Histamine Receptor
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|
ST-1006 is a potent histamine H4 receptor agonist (pKi: 7.94).ST-1006 has anti-inflammatory effects.ST-1006 is a potent inducer of basophil migration and induces basophil migration.ST-1006 is a potent inducer of basophil... |
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T0217L |
(+)-Dropropizine
|
(+)-Dropropizine |
Histamine Receptor
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(+)-Dropropizine can inhibit histamine receptor, anti-allergic, and reduce a cough by modulation of neuropeptides involved in the cough reflex and by interfering with stimulus activation of peripheral endings of sensory ... |
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T1639 |
Amlexanox
|
CHX3673,Amoxanox,AA673 |
IL Receptor
,
FGFR
,
Others
,
IκB/IKK
|
|
Amlexanox (AA673) is an anti-aphthous ulcer drug. Amlexanox inhibits the synthesis and release of inflammatory mediators, including leukotrienes and histamine, from mast cells, neutrophils, and mononuclear cells. Amlexan... |
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T4195 |
Betahistine
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PT 9 base,Vasomotal,Serc base |
Histamine Receptor
|
|
Betahistine (Vasomotal) is a histamine analog and H1 receptor agonist that serves as a vasodilator. It is used in MENIERE DISEASE and in vascular headaches but may exacerbate bronchial asthma and peptic ulcers. Betahisti... |
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T40652 |
Meclizine
|
Meclozine |
Histamine Receptor
|
|
Meclizine, also known as Meclozine, is a piperazine class H1 antagonist with antihistamine properties that inhibits the interaction of histamine at H1 receptors reversibly. It serves as an effective anti-motion sickness ... |
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T4978 |
Sarpogrelate hydrochloride
|
MCI-9042 |
5-HT Receptor
|
|
Sarpogrelate hydrochloride (MCI-9042) , a selective 5-HT2 antagonist, has been widely used as an anti-platelet agent for the treatment of PAD. Target: 5-HT2 Recepter Sarpogrelate is a drug which acts as an antagonist at ... |
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T27388 |
FR-A 19
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FR-A-19,FRA19 |
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FR-A 19, a Histamine H2 agonist, inhibits the release of IgE-mediated human basophil histamine in a nanomolar range. It has additional potent anti-allergic properties. |
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T21388 |
Emedastine Difumarate
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Rapimine,DSSTox_CID_26911,AL-3432A,KB-2413,Emedastine fumarate,KB 2413 |
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Emedastine Difumarate is a selective histamine H1 receptor antagonist with anti-allergic activity, prescribed for allergic conjunctivitis. Upon ocular administration, emedastine causes a dose-dependent inhibition of hist... |
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T23597 |
A-940894
|
A940894,A 940894 |
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A-940894 is a histamine H4 receptor antagonist with anti-inflammatory properties. A-940894 potently binds to both human and rat histamine H4 receptors and exhibits considerably lower affinity for the human histamine H1, ... |
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T24951 |
VUF-10497
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|
|
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VUF-10497 is a histamine H4 receptor inverse agonist (pKi = 7.57). VUF-10497 was found to possess anti-inflammatory properties in vivo in the rat. VUF-10497 also possesses a considerable affinity for the human histamine ... |
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T26491 |
AA 2379
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AA2379,AA-2379 |
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AA 2379, an anti inflammatory agent, inhibits the vascular permeability induced by histamine, serotonin, and bradykinin. It also has some analgesic activity. |
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T0157L |
Roxatidine acetate
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|
|
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Roxatidine acetate is an anti-ulcer agent and histamine antagonist that inhibits gastric acid secretion. Compared to other similar drugs, Roxatidine acetate has an improved safety profile, in part because lower doses of ... |
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T68206 |
Arbortristoside A
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|
|
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Arbortristoside A is an anti-inflammatory and antinociceptive. This activity may be due to the inhibiting effect of prostaglandin, histamine and serotonin. Arbortristoside A has also been shown to act on ulcerations and ... |
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T60498 |
Chlorpheniramine
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|
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Chlorpheniramine is an H1 anti-histamine agent for IgE-mediated inflammation that is commonly used for allergic diseases. |
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T74118 |
Roxatidine
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Roxatidine, the active metabolite of Roxatidine acetate hydrochloride, serves as a histamine H2-receptor antagonist and exhibits anti-ulcer properties. It functions by suppressing the release of histamine, thereby inhibi... |
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T68200 |
Roxatidine hydrochloride
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|
|
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Roxatidine hydrochloride is an anti-ulcer agent and histamine antagonist that suppresses gastric acid secretion. It effectively heals duodenal and gastric ulcers and reduces ulcer pain. Roxatidine acetate has an improved... |
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TP1408 |
Peptide 401
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|
|
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Peptide 401 is an antimicrobial peptide (AMP) derived from the venom of bees and wasps. Peptide 401 induces mast cell degranulation, activating histamine release from peritoneal mast cells. Additionally, peptide 401 exhi... |
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T73352 |
A-943931
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A-943931, a selective and potent antagonist of the histamine H4 receptor (H4R), demonstrates affinity with pKi values of 4.6 and 3.8 nM for human and rat H4Rs, respectively. This compound exhibits anti-inflammatory and a... |
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T60584 |
Cimetidine hydrochloride
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|
|
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Cimetidine (SKF-92334) hydrochloride is an orally active and inverse histamine H2 receptor antagonist with a Ki of 0.6 μM. Cimetidine hydrochloride shows anti-cancer and anti-inflammatory activity. Cimetidine hydrochlori... |
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T71141 |
Fenspiride-d5
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|
|
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Fenspiride-d5 is intended for use as an internal standard for the quantification of fenspiride by GC- or LC-MS. Fenspiride is an antagonist of histamine H1 receptors and a non-steroidal anti-inflammatory drug (NSAID). It... |
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T61603 |
H3R antagonist 2
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H3R antagonist 2 (Compound 23) is a multitarget histamine H3 receptor antagonist. It exhibits inhibitory effects on acetylcholinesterase, butyrylcholinesterase, and human monoamine oxidase B (hMAO B) with IC50 values of ... |
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T71059 |
Ranitidine bismuth citrate
|
IST 622 |
|
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Ranitidine bismuth citrate, an orally administered Histamine H2-receptor antagonist, demonstrates a potent inhibitory concentration (IC 50) of 3.3 μM and exhibits high selectivity towards SARS-CoV-2-infected cells. It is... |
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T22018 |
A 987306
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|
|
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A-987306 is a potent and oral bioavailable histamine H 4 antagonist, with Kis of 3.4 nM and 5.8 nM for rat H4, and human H4. A-987306 exhibits anti-inflammatory activity in mice peritonitis model [1]. |
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T61011 |
Izuforant
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|
|
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Izuforant (JW1601) (Compound 24) has potent anti-inflammatory and anti-pruritic activities. Izuforant has a binding affinity for human serotonin 3 receptor (h5-HT3R) with an IC50 value of 9.1 μM. Izuforant is also an ora... |
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T62460 |
INCB38579
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|
|
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INCB38579 is a selective, orally active, histamine H4 receptor (HH4R) antagonist that crosses the blood-brain barrier and acts on hH4R (IC50: 4.8 nM), mH4R (IC50: 42 nM), and rH4R (IC50: 32 nM). INCB38579 has anti-inflam... |
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T22242 |
Amodiaquine hydrochloride
|
|
|
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Amodiaquine dihydrochloride (Amodiaquin dihydrochloride), a member of the 4-aminoquinoline class, serves as an antimalarial agent and exhibits potent oral activity as a histamine N-methyltransferase inhibitor, displaying... |
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T73665 |
Bufrolin
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|
|
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Bufrolin, an analog of Cromoglycate (histamine release inhibitor) and a potent agonist of GPR35, enhances the interaction between β-arrestin-2 and both human GPR35a and rat GPR35. It stabilizes mast cells, exhibiting ant... |
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T60417 |
Fenspiride
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|
|
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Fenspiride is an antagonist of H1-histamine receptors. Fenspiride is an orally active non-steroidal anti-inflammatory agent that can be used for the treatment of respiratory tract infections and otitis media. Fenspiride ... |
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T36618 |
Rupatadine
|
|
|
|
Rupatadine (UR-12592) is a potent dual PAF/H1 antagonist with Ki of 0.55/0.1 uM(rabbit platelet membranes/guinea pig cerebellum membranes).IC50 value:Target: PAF/H1 antagonistin vitro: Rupatadine competitively inhibited ... |
