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T3990 |
AA26-9
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Phospholipase
,
Serine Protease
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AA26-9 is an effective and broad-spectrum inhibitor of serine hydrolase. |
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T24047 |
Etilevodopa hydrochloride
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Levodopa ethyl ester,Etilevodopa HCl, L-DOPA ethyl ester |
Others
,
Dopamine Receptor
,
Drug Metabolite
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Etilevodopa hydrochloride (L-DOPA ethyl ester) is a prodrug of levodopa. It also has greater gastric solubility and significant brain penetration. |
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T3359 |
Aprotinin
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Bovine Pancreatic Trypsin Inhibitor,Traskolan,Antilysin |
Others
,
Serine Protease
,
Influenza Virus
,
Proteasome
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Aprotinin (Traskolan) a broad-spectrum serine protease inhibitor, inhibiting the activity of a number of different esterases and proteases, including trypsin, chymotrypsin, kallikrein, plasmin, tissue plasminogen activat... |
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T15378L |
Gemcitabine elaidate hydrochloride
|
CO-101 hydrochloride,Gemcitabine elaidate hydrochloride(210829-30-4(free base)),Gemcitabine 5'-elaidate hydrochloride,CP-4126 hydrochloride |
Others
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Gemcitabine elaidate (CP-4126) hydrochloride is lipophilic pro-drug of Gemcitabine. Gemcitabine elaidate hydrochloride is converted to Gemcitabine by esterases in order to be phosphorylated. In contrast to gemcitabine, G... |
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T14319 |
Aripiprazole Lauroxil
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Dopamine Receptor
,
5-HT Receptor
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Aripiprazole lauroxil, the N-acyloxymethyl prodrug form of aripiprazole, a long-acting injectable (LAI) antipsychotic. Aripiprazole lauroxil is cleaved by esterases in vivo to N-hydroxymethyl aripiprazole (lauric acid), ... |
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T14048 |
5-CFDA
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5-Carboxyfluorescein diacetate |
Others
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5-CFDA (5-Carboxyfluorescein diacetate)(5-Carboxyfluorescein diacetate) is membrane-permeant. It can be loaded into cells via incubation and hydrolyzed by intracellular esterases to 5-carboxyfluorescein that is used for ... |
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T15082 |
DDAO
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Others
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DDAO is a promising near-infrared (NIR) red fluorescent probe with long emission wavelength (λem = 656 nm) and tunable excitation wavelength (600-650 nm). It can de desiged for detection of the activities of different en... |
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T3934 |
Isavuconazonium sulfate
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Antifungal
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Isavuconazonium sulfate is hydrolyzed by plasma esterases to yield the active moiety isavuconazole. Isavuconazole binds to and inhibits the fungal cytochrome P450 family enzyme lanosterol 14-alpha-demethylase (CYP51), wh... |
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T68889 |
Esterastin
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Esterastin is an Inhibitor of esterases. |
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T25755 |
Lorajmine
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Lorajmina |
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Lorajmine, a monochloroacetyl derivative of ajmaline, is a class Ia antiarrhythmic agent that is rapidly hydrolyzed to ajmaline by plasma and tissue esterases. |
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T20518 |
Fosinoprilat
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SQ-27,519,Fosinopril diacid,SQ 27,519,SQ27,519 |
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Fosinoprilat, an active phosphinic acid metabolite of prodrug fosenopril, is activated by esterases in vivo. Fosinoprilat binds zinc with phosphinic acid group. |
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T4574L |
Sacubitril sodium
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AHU377,AHU-377,LCZ696,AHU 377 |
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Sacubitril is an angiotensin receptor neprilysin inhibitor being studied for use in combination with valsartan for heart failure. Sacubitril is a prodrug that is activated to LBQ657 by de-ethylation via esterases. |
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T35612 |
CytoCalcein™ Violet 500
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|
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CytoCalcein Violet 500 is a fluorogenic dye used to assess cell viability. It is a cell-permeable dye that, upon entering cells, is cleaved by intracellular esterases. CytoCalcein Violet 500 is retained by living cells... |
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T26611 |
AM7499
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AM 7499,AM-7499 |
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AM7499 is a non-selective cannabinoid receptor agonist with remarkably high in vitro and in vivo potency. It is readily hydrolysed by plasma esterases and to be less prone to deposition in bodily fat than existing classi... |
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T37290 |
Resolvin D3 methyl ester
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|
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Resolvin D3 methyl ester is a methyl ester version of the free acid that may act as a lipophilic prodrug form that will alter its distribution and pharmacokinetic properties. The methyl ester moiety is susceptible to cle... |
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T35611 |
CytoCalcein™ Violet 450
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|
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CytoCalcein Violet 450 is a fluorogenic dye used to assess cell viability. It is a cell-permeable dye that, upon entering cells, is cleaved by intracellular esterases. CytoCalcein Violet 450 is retained by living cells... |
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T70621 |
Cefditoren Pivoxil HCl
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|
|
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Cefditoren Pivoxil is a semi-synthetic, broad-spectrum, beta-lactamase resistant, third-generation cephalosporin antibiotic with bactericidal activity. Cefditoren pivoxil is a prodrug that is rapidly hydrolyzed by intest... |
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T36369 |
3,6-diacetoxy Phthalonitrile
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|
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3,6-diacetoxy Phthalonitrile is a fluorescent probe for monitoring intracellular pH by flow cytometry in living cells. It rapidly crosses cell membranes and is cleaved by cytosolic esterases to form the fluorescent pH in... |
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T38352 |
Ebelactone A
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Ebelactone A is a β-lactone enzyme inhibitor that was first isolated from a cultured strain of soil actinomycetes. It can inhibit esterases, lipases, and N-formylmethionine aminopeptidases (IC50s = 0.056, 0.003, and 0.08... |
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T36325 |
Calcein Blue AM
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Calcein Blue AM is a live cell labeling dye that permeates the cell membrane. Upon entering cells, intracellular esterases cleave the ester group of acetoxymethyl (AM), producing Calcein Blue fluorescent dye that is impe... |
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T37918 |
Prostaglandin E2 isopropyl ester
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Prostaglandin E2 isopropyl ester |
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Prostaglandin E2 (PGE2) isopropyl ester is a more lipophilic form of the free acid, PGE2. PG esters have enhanced lipid solubility compared to their parent compounds. They are generally hydrolyzed to the free acid by end... |
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T35939 |
Dabigatran Acyl-β-D-Glucuronide
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Dabigatran acyl-β-D-glucuronide is a major active metabolite of the thrombin inhibitor dabigatran . The prodrug of dabigatran, dabigatran etexilate , is hydrolyzed by plasma esterases to form dabigatran, which is metabol... |
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T36327 |
Calcein Red™ AM
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Calcein Red AM is a fluorogenic dye that is used to assess cell viability. As the acetoxymethyl ester, Calcein Red AM is non-fluorescent but cell-permeant and is hydrolyzed to the fluorescent probe Calcein Red by intr... |
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T38123 |
5(6)-Carboxy-2′,7′-dichlorofluorescein diacetate
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|
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5(6)-Carboxy-2’,7’-dichlorofluorescein diacetate is an oxidant-sensitive and cell-permeable fluorescent probe.1Base hydrolysis of the ester bonds by intracellular esterases releases the acetate groups and the resulting c... |
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T36388 |
Rhod-5N AM
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Rhod-5N AM is a cell-permeant acetoxymethyl ester of the fluorescent calcium indicator rhod-5N . As rhod-5N AM enters cells, it is hydrolyzed by intracellular esterases to produce rhod-5N. Rhod-5N displays a low affinity... |
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T37169 |
Resolvin D2 methyl ester
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|
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Resolvin D2 (RvD2) is a lipid mediator biosynthesized by the sequential oxygenation of docosahexaenoic acid by 15- and 5-lipoxygenase. It evokes diverse anti-inflammatory effects which may mediate the resolution of infla... |
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T15378 |
Gemcitabine elaidate
|
Gemcitabine 5'-elaidate,Gemcitabine (elaidate),CO-101,CP-4126 |
Apoptosis
,
Nucleoside Antimetabolite/Analog
,
Autophagy
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|
Gemcitabine elaidate (CP-4126), is a lipophilic, unsaturated fatty acid ester derivative of gemcitabine (dFdC), an antimetabolite deoxynucleoside analogue, with potential antineoplastic activity. Upon hydrolysis intracel... |
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T37320 |
Rhod-FF AM
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Rhod-FF AM is a cell-permeant acetoxymethyl ester of the fluorescent calcium indicator rhod-FF . As rhod-FF AM enters cells, it is hydrolyzed by intracellular esterases to produce rhod-FF. Rhod-FF is a difluorinated anal... |
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T37168 |
Resolvin D1 methyl ester
|
Resolvin D1 methyl ester |
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Resolvin D1 is produced physiologically from the sequential oxygenation of docosahexaenoic acid by 15- and 5-lipoxygenase . It reduces human polymorphonuclear leukocyte transendothelial migration, the earliest event in a... |
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T37188 |
BTC AM
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BTC AM is a cell-permeable acetoxy-methyl ester of BTC . As BTC AM enters cells, it is hydrolyzed by intracellular esterases to produce BTC. BTC is a low affinity calcium indicator (Kd = 7-26 μM) that displays excitation... |
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T36112 |
Clopidogrel Carboxylic Acid (hydrochloride)
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|
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Clopidogrel is an antithrombic compound whose active metabolite is a selective, irreversible antagonist of the platelet purinergic P2Y12 receptor (IC50 = 100 nM). Clopidogrel inhibits ADP-induced platelet aggregation ex ... |
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T36871 |
5-Octyl-α-ketoglutarate
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|
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In addition to its role in the Krebs cycle, α-ketoglutarate (2-oxoglutarate) has roles as a substrate or modulator of enzymes. 5-Octyl-α-ketoglutarate, also known as α-ketoglutarate octyl ester, is a stable, cell-permeab... |
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T71305 |
Clofibric Acid-d4
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|
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Clofibric acid-d4 is intended for use as an internal standard for the quantification of clofibric acid by GC- or LC-MS. Clofibric acid is a peroxisome proliferator-activated receptor α (PPARα) agonist (EC50 = 50 µM in a ... |
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T83293 |
5-CFDA-AM
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|
|
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5-CFDA-AM is a cell-permeable esterase substrate employed as an active probe to assess enzyme activity and cell membrane integrity. Electroneutral and capable of entering cells at concentrations lower than CFDA, it under... |
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T37762 |
Fura-FF AM
|
|
|
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Fura-FF AM is a cell-permeable acetoxymethyl ester of the fluorescence calcium indicator fura-FF (potassium salt) . As fura-FF AM enters cells, it is hydrolyzed by intracellular esterases to produce fura-FF. Fura-FF is a... |
