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カタログ番号 | 製品名 | 別名 | ターゲット |
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T78573 | Glucocerebrosidase | GCase,Glucosylceramidase | Endogenous Metabolite |
Glucocerebrosidase (Glucosylceramidase; GBA), a lysosomal enzyme, catalyzes the hydrolysis of the β-glucosidic linkage in glucocerebroside (GC) to yield glucose and ceramide [1]. | |||
T60353 | Glucocerebrosidase-IN-1 | ||
Glucocerebrosidase-IN-1 (compound 11a) is a potent and selective GCase (glucocerebrosidase) inhibitor, with an IC 50 of 29.3 μM and a K i of 18.5 μM. Due to GCase involvement in pathological disorders consequent to enzym... | |||
T78671 | Glucocerebrosidase-IN-1 hydrochloride | Glucosidase | |
Glucocerebrosidase-IN-1 (compound 11a) hydrochloride is a potent, selective GCase (glucocerebrosidase) inhibitor with IC50 and Ki values of 29.3 μM and 18.5 μM, respectively. It is utilized in the research of Gaucher dis... | |||
T8986 | ML198 | Glucokinase | |
ML198 is a novel activator and non-inhibitory chaperone of glucocerebrosidase. ML198 serves as a starting point to develop a novel approach towards small molecule treatment for patients suffering from Gaucher disease. | |||
T0920 | Ambroxol | Ambroxolum,NA-872 | P450 , Autophagy |
Ambroxol (NA-872) is a secretolytic agent used in the treatment of respiratory diseases associated with viscid or excessive mucus. It is the active ingredient of Mucosolvan, Lasolvan or Mucoangin. The substance is a muco... | |||
T6234 | Ambroxol hydrochloride | Mucosolvan,Mucoangin,Ambroxol HCl | Sodium Channel , Autophagy |
Ambroxol hydrochloride (Mucosolvan) is a metabolite of BROMHEXINE that stimulates mucociliary action and clears the air passages in the respiratory tract. It is usually administered as the hydrochloride. | |||
T40544 | NCGC00092410 | ML008 | Glucosidase |
NCGC00092410 (ML008) is a glucocerebrosidase (GC) inhibitor with IC50 value of 31 nM. It can be used for the study of Gaucher disease caused by mutation of glucocerebrase gene. | |||
T8989 | NCGC 607 | NCGC607 | Others |
NCGC 607 is a a noninhibitory chaperone of glucocerebrosidase (GCase). | |||
T60048 | WAY-640509 | Glucokinase | |
WAY-640509 is a glucocerebrosidase inhibitor. | |||
T4280 | Gcase activator 1 | LTI-291,LTI 291,LTI291 | Glucosidase |
Gcase activator 1 (LTI-291) is a glucocerebrosidase (Gcase) activator. | |||
T8990 | ML266 | Glucokinase | |
ML266, a glucocerebrosidase (GCase) chaperone with an IC50 of 2.5 µM, facilitates the transport of the mutant protein to the lysosome, thereby restoring GCase activity without inhibiting the enzyme's function. This compo... | |||
T39518 | PFB-FDGlu | Others | |
PFB-FDGlu is a lysosomal Glucocerebrosidase (GCase) substrate with cell-permeable specificity that is cleaved to produce fluorescein.PFB-FDGlu is often used in conjunction with a flow cytometer to measure GCase activity ... | |||
T37440 | C2 Adamantanyl Galactosylceramide (d18:1/2:0) | ||
C2 Adamantanyl Galactosylceramide (d18:1/2:0) (AdaGalCer) is a bioactive sphingolipid. It reduces globotriaosylceramide 3 synthesis from exogenous lactosylceramide in microsomes. AdaGalCer stimulates recombinant glucocer... | |||
T80994 | Therapeutic agent-1 | ||
Therapeutic Agent-1, a heteroaryl compound, serves as an enzyme replacement therapy to enhance glucocerebrosidase activity in the treatment of Gaucher disease [1]. | |||
T37928 | 13C6 Glucosylsphingosine (d18:1) | ||
13C6 Glucosylsphingosine (d18:1) is an isotopically enriched form of 1-β-D-glucosylsphingosine (d18:1) that is intended for use as an internal standard for the quantification of 1-β-D-glucosylsphingosine by GC- or LC-MS.... | |||
T38213 | 1-β-D-Glucosylsphingadienine (d18:2 (4E,8E)) | 1-β-D-Glucosylsphingadienine (d18:2 (4E,8E)) | |
1-β-D-Glucosylsphingadienine is a glucosylsphingosine, which are deacetylated lysolipid derivatives of glucosylcerebrosides . They are formed when sphingosines undergo glucosidation by UDP-glucose. Glucosylsphingosines c... |
カタログ番号 | 製品名 | 別名 | ターゲット |
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T78493 | Glucosylsphingosine | Lyso-Gb1,Glucopsychosine | |
Glucosylsphingosine (lyso-Gb1), a deacylated glucosylceramide derivative metabolized by glucocerebrosidase, serves as a promising, reliable, and specific biomarker for Gaucher disease monitoring [1]. |
カタログ番号 | 製品名 | Species | Expression System |
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TMPY-05099 | GBA/glucocerebrosidase Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Mutations in the GBA gene, encoding the lysosomal hydrolase glucocerebrosidase (GCase), are the most common known genetic risk factor for Parkinson's disease (PD) and dementia with Lewy bodies (DLB). ASAH1 (acid ceramida... |