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T2282 |
RPI-1
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|
Others
,
Phospholipase
,
c-Met/HGFR
,
c-RET
|
|
RPI-1 is a competitive, potent ATP-dependent Ret kinase inhibitor. |
|
T8843 |
APS6-45
|
|
MAPK
,
Ras
|
|
APS6-45 inhibits RAS/MAPK signaling and exhibits anti-tumor activity. |
|
T21505 |
Suberoyl bis-hydroxamic acid
|
SBHA,Suberohydroxamic acid |
Apoptosis
,
HDAC
|
|
Suberoyl bis-hydroxamic acid (SBHA) is a Histone deacetylase (HDAC) inhibitor. HDAC is required for transcriptional modulation, cell cycle regulation and development. It is an enzyme that deacetylates lysine residues on ... |
|
T23516 |
VU590
|
|
Potassium Channel
|
|
VU590 is a potent and moderately selective inhibitor of extrarenal medullary potassium ROMK (Kir1.1).VU590 inhibits Kir7.1 and modulates uterine myometrial contractility and melanocortin signalling. |
|
T13370 |
YM-46303
|
|
AChR
|
|
|
|
T13320 |
VU591 hydrochloride
|
|
Potassium Channel
|
|
VU591 hydrochloride is a selective renal outer medullary potassium channel (Kir1.1, ROMK) antagonist (IC50：0.24 μM). Thought to block the intracellular pore of the Kir1.1 channel. Exhibits no effect on Kir7.1 at concentr... |
|
TP1256 |
Adrenomedullin (AM) (22-52), human TFA
|
22-52-Adrenomedullin (human) (TFA) |
|
|
Adrenomedullin (AM) (22-52), human (22-52-Adrenomedullin human) TFAis a kind of NH2 TFA truncated at the end of the quality of adrenal medullary analogue, is a kind of quality of adrenal medullary receptor antagonist. |
|
TP1824 |
Cerebellin
|
|
|
|
Cerebellin is a 16-amino acid peptide, originally isolated from rat cerebellum, whose presence has been recently demonstrated in the human adrenal glands and especially in medullary chromaffin cells. |
|
T62760 |
ROMK-IN-32
|
|
|
|
ROMK-IN-32 is an inhibitor of the extra-renal medullary potassium channel (ROMK) (IC50: 35 nM) and also inhibits hERG (IC50: 22 μM). |
|
T62544 |
MK-8153
|
|
|
|
MK-8153 is a selective, potent, orally active inhibitor of extrarenal medullary potassium channels (ROMK), acting on ROMK EP (IC50: 5 μM) and hERG EP (IC50: 34 μM).MK-8153 can be used as a diuretic. |
|
T60493 |
Guaiacol Carbonate
|
|
|
|
Guaiacol Carbonate is an expectorant that acts via virtue of a reflex from the stomach by way of the afferent gastric nerves to the medullary centers, then via peripherally again to the respiratory tract[1]. |
|
T79726 |
RET-IN-25
|
|
|
|
RET-IN-25 (compound 6b) is an anticancer RET kinase inhibitor that demonstrates efficacy against medullary thyroid carcinoma (MTC), exhibiting half-maximal inhibitory concentrations (IC50s) of 3.6 μM at 3 days and 3.0 μM... |
|
T78203 |
NSC194598
|
|
|
|
NSC194598 is a p53 DNA-binding inhibitor, demonstrating an in vitro IC50 of 180 nM and an in vivo range of 2-40 μM. It disrupts the transcriptional activation of the mutated RET gene in human medullary thyroid carcinoma ... |
|
T63183 |
RET-IN-9
|
|
|
|
RET-IN-9 is a potent inhibitor of RET. RET kinase is a single-channel transmembrane receptor tyrosine kinase that plays an important role in the development of the kidney and enteric nervous system, as well as in the mai... |
|
T22552 |
AD57 (hydrochloride)
|
|
Others
|
|
AD57, as polypharmacological cancer therapeutic, is designed to regulate multiple targets related to cancer blocks the receptor tyrosine kinase RET in Drosophila (IC50: 2 nM). AD57 effectively suppresses tyrosine kinase ... |
