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Search Results for " negative-feedback "

ターゲット

7

阻害剤

1

天然化合物

35

リコンビナントタンパク質

カタログ番号 製品名 別名 ターゲット
T11438 GNE-1858 Others , MAPK
T61301 Chromenone 1 TGF-beta/Smad
Chromenone 1 is a potent potentiator of osteogenic bone morphogenetic protein (BMP). Chromenone 1 induces a pronounced, kinase-independent, negative TGFβ feedback that enhances nuclear BMP-Smad signaling outputs.
T68525 Nafarelin acetate hydrate
Nafarelin is a gonadotropin-releasing hormone agonist (GnRH agonist) which acts as an analog of GnRH. Nafarelin increases the release of FSH and LH by the anterior pituitary, which in turn leads to an increase of estroge...
T36781 St-Ht31 P st-Ht31 P
Negative control for st-Ht31 . Gorshkov et al (2017) AKAP-mediated feedback control of cAMP gradients in developing hippocampal neurons. Nat.Chem.Biol. 13 425 PMID:28192412 |Vijayaraghavan et al (1997) Protein kinase A-a...
T5317L Cridanimod sodium XBIO-101,XBIO 101,Cycloferon,Sodium Cridanimod,Cridanimod Na,XBIO101
Cridanimod can increase progesterone receptor (PR) expression, with potential antineoplastic adjuvant activity. Cridanimod is able to induce the expression of PR in endometrial cancer. In combination with a progestin, ca...
T76180 Urocortin III (human)
Urocortin III (human) is a corticotropin-releasing factor (CRF)-related peptide that primarily interacts with and activates the CRF receptor type 2 (CRF-R2), showing a specific distribution in the central nervous system ...
T35814 Urocortin III (human) (trifluoroacetate salt)
Urocortin III is a neuropeptide hormone and member of the corticotropin-releasing factor (CRF) family which includes mammalian CRF , urocortin , urocortin II , frog sauvagine, and piscine urotensin I.1 Human urocortin II...
カタログ番号 製品名 別名 ターゲット
T36563 (E)-Guggulsterone
Bile acids are essential for solubilization and transport of dietary lipids, are the major products of cholesterol catabolism, and are physiological ligands for farnesoid X receptor (FXR), a nuclear receptor that regulat...

Recombinant Proteins

カタログ番号 製品名 Species Expression System
TMPY-04803 DLL4 Protein, Human, Recombinant Human HEK293
Delta-like protein 4 (DLL4, Delta4), a type I membrane-bound Notch ligand, is one of five known Notch ligands in mammals and interacts predominantly with Notch 1, which has a key role in vascular development. Recent stud...
TMPY-01321 DLL4 Protein, Human, Recombinant (His) Human HEK293
Delta-like protein 4 (DLL4, Delta4), a type I membrane-bound Notch ligand, is one of five known Notch ligands in mammals and interacts predominantly with Notch 1, which has a key role in vascular development. Recent stud...
TMPY-00776 DLL4 Protein, Human, Recombinant (hFc) Human HEK293
Delta-like protein 4 (DLL4, Delta4), a type I membrane-bound Notch ligand, is one of five known Notch ligands in mammals and interacts predominantly with Notch 1, which has a key role in vascular development. Recent stud...
TMPY-01337 DLL4 Protein, Mouse, Recombinant (His) Mouse HEK293
Delta-like protein 4 (DLL4, Delta4), a type I membrane-bound Notch ligand, is one of five known Notch ligands in mammals and interacts predominantly with Notch 1, which has a key role in vascular development. Recent stud...
TMPJ-00889 IL-13 Protein, Mouse, Recombinant (aa 22-131, His) Mouse Human Cells
Mouse interleukin 13 (mIL-13) is a pleiotropic cytokine produced by activated Th2 cells. IL-13 induces B cell proliferation and immunoglobin production. It contains a four helical bundle with two internal disulfide bonds...
TMPJ-00890 IL-13 Protein, Mouse, Recombinant (aa 26-131, His) Mouse Human Cells
Mouse interleukin 13 (mIL-13) is a pleiotropic cytokine produced by activated Th2 cells. IL-13 induces B cell proliferation and immunoglobin production. It contains a four helical bundle with two internal disulfide bonds...
TMPY-01359 ST2/IL-1 RL1 Protein, Human, Recombinant (His) Human HEK293
IL-1 receptor–like 1 (IL1RL1) is a membrane receptor involved in TH2 inflammatory responses and eosinophilia. It has previously been described that levels of the interleukin-1 like 1 (IL1RL1) protein can be used to diagn...
TMPY-04096 ST2/IL-1 RL1 Protein, Mouse, Recombinant (His) Mouse HEK293
IL-1 receptor–like 1 (IL1RL1) is a membrane receptor involved in TH2 inflammatory responses and eosinophilia. It has previously been described that levels of the interleukin-1 like 1 (IL1RL1) protein can be used to diagn...
TMPY-00849 ST2/IL-1 RL1 Protein, Human, Recombinant (hFc) Human HEK293
IL-1 receptor–like 1 (IL1RL1) is a membrane receptor involved in TH2 inflammatory responses and eosinophilia. It has previously been described that levels of the interleukin-1 like 1 (IL1RL1) protein can be used to diagn...
TMPY-00850 ST2/IL-1 RL1 Protein, Human, Recombinant Human HEK293
IL-1 receptor–like 1 (IL1RL1) is a membrane receptor involved in TH2 inflammatory responses and eosinophilia. It has previously been described that levels of the interleukin-1 like 1 (IL1RL1) protein can be used to diagn...
TMPY-03235 BST2 Protein, Human, Recombinant (His) Human HEK293
BST2 was frequently overexpressed in GC tissues compared with the adjacent non-tumorous tissues, and high BST2 expression was correlated with tumor stage and lymphatic metastasis. Furthermore, in vitro experiments demons...
TMPY-01461 EMAP-II/AIMP1 Protein, Human, Recombinant (His) Human E. coli
Aminoacyl tRNA synthase complex-interacting multifunctional protein 1, also known as Multisynthase complex auxiliary component p43, Endothelial monocyte-activating polypeptide II, AIMP1, EMAP2 and SCYE1, is a nucleus pro...
TMPY-02264 LRIG1 Protein, Mouse, Recombinant (His) Mouse HEK293
Leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1) is a tumor suppressor and a negative regulator of several receptor tyrosine kinases. Leucine-rich repeats and immunoglobulin-like domains containing protein ...
TMPK-01001 RNF43 Protein, Mouse, Recombinant (hFc) Mouse HEK293
RNF43 (E3 ubiquitin-protein ligase RNF43 or RING-type E3 ubiquitin transferase RNF43) functions as a tumor suppressor, by exerting a predominant negative feedback mechanism in the Wnt/β-catenin signaling pathway. RNF43 i...
TMPH-02155 SOCS1 Protein, Human, Recombinant (E. coli, His) Human E. coli
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Through ...
TMPH-02919 SOCS1 Protein, Mouse, Recombinant (His & Myc) Mouse E. coli
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Through ...
TMPH-02156 SOCS1 Protein, Human, Recombinant (His) Human Yeast
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Through ...
TMPY-06876 DLL4 Protein, Human, Recombinant (His & Avi), Biotinylated Human HEK293
Delta-like protein 4 (DLL4, Delta4), a type I membrane-bound Notch ligand, is one of five known Notch ligands in mammals and interacts predominantly with Notch 1, which has a key role in vascular development. Recent stud...
TMPY-05796 DLL4 Protein, Mouse, Recombinant (mFc) Mouse HEK293
Delta-like protein 4 (DLL4, Delta4), a type I membrane-bound Notch ligand, is one of five known Notch ligands in mammals and interacts predominantly with Notch 1, which has a key role in vascular development. Recent stud...
TMPY-05093 DLL4 Protein, Rhesus, Recombinant (His) Rhesus HEK293
Delta-like protein 4 (DLL4, Delta4), a type I membrane-bound Notch ligand, is one of five known Notch ligands in mammals and interacts predominantly with Notch 1, which has a key role in vascular development. Recent stud...
TMPH-01887 Polycystin-1 Protein, Human, Recombinant (His) Human E. coli
Component of a heteromeric calcium-permeable ion channel formed by PKD1 and PKD2 that is activated by interaction between PKD1 and a Wnt family member, such as WNT3A and WNT9B. Both PKD1 and PKD2 are required for channel...
TMPY-03493 ST2/IL-1 RL1 Protein, Mouse, Recombinant (hFc) Mouse HEK293
IL-1 receptor–like 1 (IL1RL1) is a membrane receptor involved in TH2 inflammatory responses and eosinophilia. It has previously been described that levels of the interleukin-1 like 1 (IL1RL1) protein can be used to diagn...
TMPY-02194 SOCS3 Protein, Human, Recombinant (His & Trx) Human E. coli
Suppressor of cytokine signaling 3, also known as SOCS-3, Cytokine-inducible SH2 protein 3, CIS-3, STAT-induced STAT inhibitor 3, SOCS3 and CIS3, is a protein which is widely expressed with high expression in heart, plac...
TMPY-02147 ST2/IL-1 RL1 Protein, Human, Recombinant (isoform a, His) Human HEK293
IL-1 receptor–like 1 (IL1RL1) is a membrane receptor involved in TH2 inflammatory responses and eosinophilia. It has previously been described that levels of the interleukin-1 like 1 (IL1RL1) protein can be used to diagn...
TMPY-05452 ST2/IL-1 RL1 Protein, Cynomolgus, Recombinant (His) Cynomolgus HEK293
IL-1 receptor–like 1 (IL1RL1) is a membrane receptor involved in TH2 inflammatory responses and eosinophilia. It has previously been described that levels of the interleukin-1 like 1 (IL1RL1) protein can be used to diagn...
TMPH-02948 TRIB3 Protein, Mouse, Recombinant (His & Myc) Mouse E. coli
Inactive protein kinase which acts as a regulator of the integrated stress response (ISR), a process for adaptation to various stress. Inhibits the transcriptional activity of DDIT3/CHOP and is involved in DDIT3/CHOP-dep...
TMPY-04742 BST2 Protein, Mouse, Recombinant (His) Mouse HEK293
BST2 was frequently overexpressed in GC tissues compared with the adjacent non-tumorous tissues, and high BST2 expression was correlated with tumor stage and lymphatic metastasis. Furthermore, in vitro experiments demons...
TMPH-01535 INSIG2 Protein, Human, Recombinant (His & Myc) Human in vitro E. coli expression system
Oxysterol-binding protein that mediates feedback control of cholesterol synthesis by controlling both endoplasmic reticulum to Golgi transport of SCAP and degradation of HMGCR. Acts as a negative regulator of cholesterol...
TMPY-03193 BST2 Protein, Human, Recombinant (hFc) Human HEK293
BST2 was frequently overexpressed in GC tissues compared with the adjacent non-tumorous tissues, and high BST2 expression was correlated with tumor stage and lymphatic metastasis. Furthermore, in vitro experiments demons...
TMPY-02674 BST2 Protein, Mouse, Recombinant (hFc) Mouse HEK293
BST2 was frequently overexpressed in GC tissues compared with the adjacent non-tumorous tissues, and high BST2 expression was correlated with tumor stage and lymphatic metastasis. Furthermore, in vitro experiments demons...
TMPY-03015 EMAP-II/AIMP1 Protein, Mouse, Recombinant Mouse E. coli
Aminoacyl tRNA synthase complex-interacting multifunctional protein 1, also known as Multisynthase complex auxiliary component p43, Endothelial monocyte-activating polypeptide II, AIMP1, EMAP2 and SCYE1, is a nucleus pro...
TMPY-00844 IL-17RD Protein, Human, Recombinant (His) Human HEK293
Interleukin-17 receptor D (IL-17D) also known as Interleukin-17 receptor-like protein, is a member of the interleukine-17 receptor family. IL-17RD functions as a feedback inhibitor of fibroblast growth factor-mediated Ra...
TMPY-00625 IL-17RD Protein, Canine, Recombinant (His) Canine HEK293
Interleukin-17 receptor D (IL-17D) also known as Interleukin-17 receptor-like protein, is a member of the interleukine-17 receptor family. IL-17RD functions as a feedback inhibitor of fibroblast growth factor-mediated Ra...
TMPY-00338 IL-17RD Protein, Canine, Recombinant (hFc) Canine HEK293
Interleukin-17 receptor D (IL-17D) also known as Interleukin-17 receptor-like protein, is a member of the interleukine-17 receptor family. IL-17RD functions as a feedback inhibitor of fibroblast growth factor-mediated Ra...
TMPH-02640 ZC3H12A Protein, Mouse, Recombinant (His & Myc) Mouse E. coli
Endoribonuclease involved in various biological functions such as cellular inflammatory response and immune homeostasis, glial differentiation of neuroprogenitor cells, cell death of cardiomyocytes, adipogenesis and angi...
DLL4 Protein, Human, Recombinant
TMPY-04803
Species: Human
Expression System: HEK293
DLL4 Protein, Human, Recombinant (His)
TMPY-01321
Species: Human
Expression System: HEK293
DLL4 Protein, Human, Recombinant (hFc)
TMPY-00776
Species: Human
Expression System: HEK293
DLL4 Protein, Mouse, Recombinant (His)
TMPY-01337
Species: Mouse
Expression System: HEK293
IL-13 Protein, Mouse, Recombinant (aa 22-131, His)
TMPJ-00889
Species: Mouse
Expression System: Human Cells
IL-13 Protein, Mouse, Recombinant (aa 26-131, His)
TMPJ-00890
Species: Mouse
Expression System: Human Cells
ST2/IL-1 RL1 Protein, Human, Recombinant (His)
TMPY-01359
Species: Human
Expression System: HEK293
ST2/IL-1 RL1 Protein, Mouse, Recombinant (His)
TMPY-04096
Species: Mouse
Expression System: HEK293
ST2/IL-1 RL1 Protein, Human, Recombinant (hFc)
TMPY-00849
Species: Human
Expression System: HEK293
ST2/IL-1 RL1 Protein, Human, Recombinant
TMPY-00850
Species: Human
Expression System: HEK293
BST2 Protein, Human, Recombinant (His)
TMPY-03235
Species: Human
Expression System: HEK293
EMAP-II/AIMP1 Protein, Human, Recombinant (His)
TMPY-01461
Species: Human
Expression System: E. coli
LRIG1 Protein, Mouse, Recombinant (His)
TMPY-02264
Species: Mouse
Expression System: HEK293
RNF43 Protein, Mouse, Recombinant (hFc)
TMPK-01001
Species: Mouse
Expression System: HEK293
SOCS1 Protein, Human, Recombinant (E. coli, His)
TMPH-02155
Species: Human
Expression System: E. coli
SOCS1 Protein, Mouse, Recombinant (His & Myc)
TMPH-02919
Species: Mouse
Expression System: E. coli
SOCS1 Protein, Human, Recombinant (His)
TMPH-02156
Species: Human
Expression System: Yeast
DLL4 Protein, Human, Recombinant (His & Avi), Biotinylated
TMPY-06876
Species: Human
Expression System: HEK293
DLL4 Protein, Mouse, Recombinant (mFc)
TMPY-05796
Species: Mouse
Expression System: HEK293
DLL4 Protein, Rhesus, Recombinant (His)
TMPY-05093
Species: Rhesus
Expression System: HEK293
Polycystin-1 Protein, Human, Recombinant (His)
TMPH-01887
Species: Human
Expression System: E. coli
ST2/IL-1 RL1 Protein, Mouse, Recombinant (hFc)
TMPY-03493
Species: Mouse
Expression System: HEK293
SOCS3 Protein, Human, Recombinant (His & Trx)
TMPY-02194
Species: Human
Expression System: E. coli
ST2/IL-1 RL1 Protein, Human, Recombinant (isoform a, His)
TMPY-02147
Species: Human
Expression System: HEK293
ST2/IL-1 RL1 Protein, Cynomolgus, Recombinant (His)
TMPY-05452
Species: Cynomolgus
Expression System: HEK293
TRIB3 Protein, Mouse, Recombinant (His & Myc)
TMPH-02948
Species: Mouse
Expression System: E. coli
BST2 Protein, Mouse, Recombinant (His)
TMPY-04742
Species: Mouse
Expression System: HEK293
INSIG2 Protein, Human, Recombinant (His & Myc)
TMPH-01535
Species: Human
Expression System: in vitro E. coli expression system
BST2 Protein, Human, Recombinant (hFc)
TMPY-03193
Species: Human
Expression System: HEK293
BST2 Protein, Mouse, Recombinant (hFc)
TMPY-02674
Species: Mouse
Expression System: HEK293
EMAP-II/AIMP1 Protein, Mouse, Recombinant
TMPY-03015
Species: Mouse
Expression System: E. coli
IL-17RD Protein, Human, Recombinant (His)
TMPY-00844
Species: Human
Expression System: HEK293
IL-17RD Protein, Canine, Recombinant (His)
TMPY-00625
Species: Canine
Expression System: HEK293
IL-17RD Protein, Canine, Recombinant (hFc)
TMPY-00338
Species: Canine
Expression System: HEK293
ZC3H12A Protein, Mouse, Recombinant (His & Myc)
TMPH-02640
Species: Mouse
Expression System: E. coli