Powder: -20°C for 3 years | In solvent: -80°C for 1 year
GNE-1858 is an ATP-competitive hematopoietic progenitor kinase-1 (HPK1) inhibitor (IC50s of 1.9 nM, 1.9 nM, and 4.5 nM for wild-type and the active mimetic mutants HPK1-TSEE and HPK1-SA).
ターゲット&IC50 | HPK1: 1.9 nM |
In vitro | HPK1 is a negative-feedback regulator of T cell receptor signaling, which dampens T cell proliferation and effector function.Hematopoietic progenitor kinase-1 (HPK1), a serine/threonine Ste20-related protein kinase whose expression is restricted to the hematopoietic compartment (e.g., T cells, B cells, and dendritic cells), is one such kinase. |
分子量 | 428.48 |
分子式 | C21H26F2N8 |
CAS No. | 2680616-96-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 15 mg/mL (35.01 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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GNE-1858 2680616-96-8 MAPK Others GNE1858 hematopoietic MAP4K proliferation T-cell regulator GNE 1858 Inhibitor negative-feedback inhibit receptor signaling MAPK Kinase Kinase Kinase progenitor inhibitor