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Search Results for " ob/ob "

阻害剤

リコンビナントタンパク質

カタログ番号	製品名	別名	ターゲット
T41175	OB 24 hydrochloride
	OB 24 hydrochloride is a potent and selective heme oxygenase 1 (HO-1) inhibitor (IC50 values are 1.9 and >100 μM for HO-1 and HO-2 respectively), reduces protein carbonylation and reactive oxygen species formation in adv...
T28224	OB-2
	OB-2 is an inhibitor of stomatin-like protein-3 (STOML3) oligomerization. OB-2 reversibly reduces the sensitivity of mechanically gated currents in sensory neurons and silence mechanoreceptors in vivo.
T68288	OB-24 free base
	OB-24 free base is a potent and selective heme oxygenase 1 (HO-1) inhibitor.
T28223	OB-1
	OB-1 is an inhibitor of stomatin-like protein-3 (STOML3) oligomerization. OB-1 reversibly reduces the sensitivity of mechanically gated currents in sensory neurons and silence mechanoreceptors in vivo.
T9266	Fatostatin		Lipid , Fatty Acid Synthase
	Fatostatin is a specific inhibitor of SREBP activation, it impairs the activation of SREBP-1 and SREBP-2. Fatostatin binds to SCAP (SREBP cleavage-activating protein), and inhibits the ER-Golgi translocation of SREBPs.		Lipid , Fatty Acid Synthase
T6832	Fatostatin hydrobromide	Fatostatin HBr,Fatostatin A,Fatostatin A HBr,Fatostatin	NPC1L1 , Fatty Acid Synthase
	Fatostatin hydrobromide (Fatostatin A HBr) ia an inhibitor of sterol regulatory element binding protein (SREBP). It impairs the activation of SREBP-1 and SREBP-2.		NPC1L1 , Fatty Acid Synthase
T71294	BMS-763534
	BMS-763534 is a potent antagonist of corticotropin-releasing factor/hormone receptor 1 (CRHR-1).
T31752	FD&C Yellow No. 4	NSC-11234,NSC11234,Yellow OB,NSC 11234
	FD&C Yellow No. 4 is a dye.
T3312	AM-2394	AM2394	Glucokinase
	AM-2394 is an effective and specific Glucokinase agonist (GKA, EC50: 60 nM), which catalyzes the phosphorylation of glucose to glucose-6-phosphate. AM-2394(AM2394) increases the affinity of GK for glucose by approximatel...		Glucokinase
T23557	Talibegron hydrochloride	ZD2079 hydrochloride,ZD 2079	Adrenergic Receptor
	Talibegron hydrochloride (ZD2079 hydrochloride) is an β3 adrenergic receptor agonist with a pD2 of 3.72 on phenylephrine-preconstricted rat mesenteric artery. Relaxes rat mesenteric artery and isolated aorta in vitro. In...		Adrenergic Receptor
T70509	INU-101
	INU-101 is an 11β-HSD1 inhibitor. In KKAy mice, ob/ob mice, and ZDF rats, oral administration of INU-101 led to enhanced insulin sensitivity and the lowering of the fasting level of glucose in the blood. INU-101 therefor...
T27239	Edaglitazone	Edaglitazone sodium,BM-13.1258,RO-2052349-602,R-483,RO-2052349-000
	Edaglitazone is a PPARγ agonist. Edarglitazone restores acute inflammatory responses to cerebral hypoxia-ischemia in the diabetic ob/ob mouse.
TP2020	[Pro3]-GIP (Mouse)
	GIP receptor antagonist (IC50 = 2.6μM). Inhibits GIP-stimulated insulin release from pancreatic β cells in vitro. In ob/ob mice, blocks the effects of GIP on insulin release and plasma glucose levels. Also improves intra...
T83696	Gastric Inhibitory Peptide 1 (3-42) (human) TFA	Glucose-dependent Insulinotropic Polypeptide 3-42,GIP-1 (3-42)
	Gastric inhibitory peptide 1 (GIP-1) (3-42), a fragment of the incretin hormone GIP and antagonist to the GIP receptor, is generated through the action of serum dipeptidyl peptidase 4 (DDP-4). When administered at 25 nmo...
T71296	4-Aaqb
	4-Aaqb, also known as OB-318, is a natural inhibitor of the autophagy pathway, enhancing immune function, suppressing MAPK and NFκB, showing anti-inflammatory, hypoglycemic, vasorelaxative, and antiproliferative activiti...
TP1356	Leptin (22-56), human
	Leptin(22-56),human is a peptide fragment of Leptin, which ACTS through a variety of subtypes of Ob-Rs.
T16507	PF-5006739		Casein Kinase
	PF-5006739 is an effective and selective inhibitor of CK1δ/ε (IC50s: 3.9 nM and 17.0 nM, respectively). PF-5006739 is a potential therapeutic agent for a range of psychiatric disorders with low nanomolar in vitro potency...		Casein Kinase
T69603	BR103354
	BR103354 is a novel fibroblast activation protein (FAP) inhibitor with anti-diabetic and anti-steatotic effects. BR103354 inhibited FAP with an IC50 value of 14 nM, showing high selectivity against dipeptidyl peptidase (...

Compounds

Target: Lipid, Fatty Acid Synthase

Fatostatin hydrobromide

T6832

Synonym: Fatostatin HBr,Fatostatin A,Fatostatin A HBr,Fatostatin

Target: NPC1L1, Fatty Acid Synthase

Synonym: NSC-11234,NSC11234,Yellow OB,NSC 11234

Talibegron hydrochloride

T23557

Synonym: ZD2079 hydrochloride,ZD 2079

Target: Adrenergic Receptor

Synonym: Edaglitazone sodium,BM-13.1258,RO-2052349-602,R-483,RO-2052349-000

Gastric Inhibitory Peptide 1 (3-42) (human) TFA

T83696

Synonym: Glucose-dependent Insulinotropic Polypeptide 3-42,GIP-1 (3-42)

Leptin (22-56), human

Target: Casein Kinase

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPY-00875	Leptin Protein, Human, Recombinant	Human	E. coli
	Leptin Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 16 kDa and the accession number is A4D0Y8.
TMPY-01725	Leptin Receptor Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Leptin Receptor Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 95 kDa and the accession number is P48357-1.
TMPY-06375	Leptin Protein, Mouse, Recombinant (mFc)	Mouse	HEK293 Cells
	Leptin Protein, Mouse, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 43.33 kDa and the accession number is P41160.
TMPK-00587	CDH11 Protein, Human, Recombinant (aa 54-617, His)	Human	HEK293 Cells
	CDH11 belongs to a group of transmembrane proteins that are principally located in adherens junctions. CDH11 mediates homophilic cell-to-cell adhesion, which may promote the development of cirrhosis. CDH11 expression was...
TMPJ-00976	LEPR Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	LEPR Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-10His tag. The predicted molecular weight is 120-150 KDa and the accession number is P48356.
TMPJ-00975	LEPR Protein, Mouse, Recombinant (hFc)	Mouse	HEK293 Cells
	LEPR Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 130-190 KDa and the accession number is P48356.
TMPJ-00977	LEPR Protein, Mouse, Recombinant (mFc)	Mouse	HEK293 Cells
	LEPR Protein, Mouse, Recombinant (mFc) is expressed in HEK293 mammalian cells with C-mFc tag. The predicted molecular weight is 130-190 KDa and the accession number is P48356.
TMPJ-00411	LEPR Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	LEPR Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 150-180 KDa and the accession number is P48357.
TMPK-00050	Leptin Protein, Mouse, Recombinant (hFc)	Mouse	HEK293 Cells
	Leptin has key roles in the regulation of energy balance, body weight, metabolism, and endocrine function. Leptin levels are undetectable or very low in patients with lipodystrophy, hypothalamic amenorrhea, and congenita...
TMPJ-00606	Leptin Protein, Carassius auratus, Recombinant (His)	Carassius auratus	P. pastoris (Yeast)
	Leptin is a hormone secreted from white adipocytes and plays important role in the regulation of food intake and energy balance. Leptin functions via signaling pathways involving OB-R in hypothalamus. In mammals, leptin ...
TMPJ-00052	Leptin Protein, Mouse, Recombinant	Mouse	E. coli
	Leptin is a hormone secreted from white adipocytes and plays important role in the regulation of food intake and energy balance. Leptin functions via signaling pathways involving OB-R in hypothalamus. Animal models have ...
TMPJ-01267	CDH11 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Cadherin-11 is a type II classical cadherin member of the cadherin superfamily of integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Cadherins interact with themselves in a homophilic manner in...
TMPY-00874	Leptin Receptor Protein, Human, Recombinant (His & hFc)	Human	HEK293 Cells
	Leptin Receptor Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 121.4 kDa and the accession number is P48357-1.
TMPK-00718	Siglec-5 Protein, Human, Recombinant (His & Avi)	Human	HEK293 Cells
	Siglec-5 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 49.3 kDa and the accession number is O15389.
TMPK-00719	Siglec-5 Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293 Cells
	Siglec-5 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 49.3 kDa and the accession number is O15389.
TMPK-00720	Siglec-5 Protein (Primary Amine Labeling), Human, Recombinant (hFc), Biotinylated	Human	HEK293 Cells
	Group B Streptococcus (GBS) causes invasive infections in human newborns. the GBS β-protein attenuates innate immune responses by binding to sialic acid-binding immunoglobulin-like lectin 5 (Siglec-5), an inhibitory rece...
TMPK-00729	Siglec-6 Protein, Human, Recombinant (His & Avi)	Human	HEK293 Cells
	Siglecs (Sialic acid binding Ig-like Lectins) are I-type (Ig-type) lectins that belong to the Ig superfamily. They are characterized by an N-terminal Ig-like V-type domain which mediates sialic acid binding, followed by ...
TMPY-02884	Siglec-5 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	Siglec-5 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 73.4 kDa and the accession number is O15389.
TMPY-03549	Siglec-5 Protein, Human, Recombinant	Human	HEK293 Cells
	Siglec-5 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 47.2 kDa and the accession number is O15389.
TMPJ-00669	Siglec-5 Protein, Human, Recombinant (His & Flag & hFc)	Human	HEK293 Cells
	Human Siglec-5 are Itype(Igtype) lectins belonging to the Ig superfamily,They are characterized by an N terminal Ig-like V type domain which mediates sialic acid binding, followed by varying numbers of Ig-like C2 type do...
TMPJ-00516	OBhFc1 Protein, Human, Recombinant (His)	Human	E. coli
	CST Complex Subunit STN1 (OBFC1) is a 368 amino acid protein that contains one OB DNA-binding domain. It is a member of the STN1 family. OBFC1 is component of the CST complex, a complex that binds to single-stranded DNA ...