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T9727 |
2'-Fluoro-2'-Deoxyadenosine
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Nucleoside Antimetabolite/Analog
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2'-Fluoro-2'-Deoxyadenosine is efficiently cleaved to the toxic 2-fluoroadenine (FAde) by Escherichia coli purine nucleoside phosphorylase (PNP). 2'-Fluoro-2'-Deoxyadenosine showed good in vivo activity against tumors ex... |
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T38423 |
CL097
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CL097 |
Reactive Oxygen Species
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TLR
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CL097 is an effective agonist of TLR7 and TLR8. CL097 induces pro-inflammatory cytokines in macrophages and NADPH oxidase priming, thereby increasing the fMLF-stimulated ROS production. |
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T18898 |
5(6)-TAMRA SE
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5(6)-Carboxytetramethylrhodamine N-succinimidyl ester |
Others
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5(6)-TAMRA SE (5(6)-Carboxytetramethylrhodamine N-succinimidyl ester) is the amine-reactive, mixed isomer form of TAMRA. 5(6)-TAMRA SE is a dye for oligonucleotide labeling and automated DNA sequencing applications. |
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T18903 |
6-ROX
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6-Carboxy-X-rhodamine |
Others
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6-ROX (6-Carboxy-X-rhodamine) is a fluorescent oligonucleotide marker and acts as an acceptor molecule coupled to 5-FAM as the donor in FRET imaging with excitation of 568nm and emission of 568nm. |
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T36752 |
Dmt-2'fluoro-da(bz) amidite
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DNA/RNA Synthesis
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Dmt-2'fluoro-da(bz) amidite is a 2'-deoxy-2'-fluoro-phosphorothioate oligonucleotide with high affinity and specificity for RNA targets.Dmt-2'fluoro-da(bz) amidite is also an intermediate in the synthesis of 5'-DMT-3'-ph... |
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T13254L |
UNC10217938A HCl
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UNC10217938A HCl(1347749-97-6 Free base),UNC7938 HCl |
Others
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UNC10217938A HCl (UNC7938 HCl) is a 3-deazapteridine analog. UNC10217938A HCl exhibits strong oligonucleotide enhancing effects. UNC10217938A HCl can modulate their intracellular trafficking and release from endosomes, l... |
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T38566 |
Bz-rC Phosphoramidite
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Bz-rC Phosphoramidite is a phosphinamide monomer utilized for oligonucleotide synthesis. |
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T40556 |
2-Amino-2'-deoxyadenosine
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2-Amino-2'-deoxyadenosine is a deoxyribonucleoside used for the oligonucleotide synthesis. |
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T13254 |
UNC10217938A
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Others
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UNC10217938A is a 3-deazapteridine analog, has strong oligonucleotide enhancing effects. |
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T39479 |
Rovanersen
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WVE-120101,Rovanersen |
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Rovanersen (WVE-120101) is an antisense oligonucleotide that can be used for huntington’s disease research. |
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T37103 |
2'-OMe-A(Bz) Phosphoramidite
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2’-OMe-A(Bz) Phosphoramidite is a modified phosphoramidite monomer, which can be used for the oligonucleotide synthesis. |
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T39517 |
Suvodirsen
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WVE-210201 |
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Suvodirsen (WVE-210201) is an oligonucleotide compound with potential applications in the study of Duchenne muscular dystrophy (DMD). |
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T39480 |
Lexanersen
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WVE-120102,Lexanersen |
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Lexanersen (WVE-120102), an antisense oligonucleotide, is utilized in Huntington's disease research. |
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T36755 |
DMT-dG(dmf) Phosphoramidite
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DMT-dG(dmf) Phosphoramidite is a phosphinamide monomer employed for oligonucleotide synthesis. |
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T37102 |
2'-O-Me-C(Bz) Phosphoramidite
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2’-O-Me-C(Bz) Phosphoramidite is a modified phosphoramidite monomer, which can be used for the oligonucleotide synthesis. |
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T40506 |
5'-O-DMT-dT
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5'-O-DMT-dT,5'-O-(4,4'-Dimethoxytrityl)thymidine |
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5'-O-DMT-dT (5'-O-(4,4'-Dimethoxytrityl)thymidine) is a nucleoside derivative that finds utility in oligonucleotide synthesis. |
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T38829 |
Lademirsen
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RG-012,SAR339375 |
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Lademirsen (SAR339375; RG-012) is a highly specific antisense oligonucleotide (ASO) targeting miR-21 . Lademirsen has the potential for Alport nephropathy research. |
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T38425 |
Ac-dA Phosphoramidite
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Ac-dA Phosphoramidite is a phosphinamide monomer utilized for oligonucleotide synthesis. |
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T39141 |
7-Deaza-2'-deoxy-7-iodoadenosine
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7-Deaza-2'-deoxy-7-iodoadenosine is a modified oligonucleotide containing 7-Deazaadenine. |
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T37133 |
5'-O-DMT-2'-TBDMS-Uridine
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5’-O-DMT-2’-TBDMS-Uridine is a deoxyribonucleoside used for the oligonucleotide synthesis. |
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T40727 |
Mipomersen sodium
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Mipomersen (sodium), a second-generation, 20-base phosphorothioate antisense oligonucleotide (ASO), targets human apoB-100. |
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T38554 |
Eteplirsen
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AVI 4658 |
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Eteplirsen (AVI 4658) is a synthetic antisense oligonucleotide utilized in research for Duchenne muscular dystrophy. |
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T36753 |
DMT-dC(ac) Phosphoramidite
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DMT-dC(ac) Phosphoramidite is a phosphoramidite monomer that has been modified for use in oligonucleotide synthesis. |
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T39347 |
RG-101
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RG-101 is a hepatocyte-targeted N-acetylgalactosamine conjugated oligonucleotide that functions as an antagonist for miR-122, an essential host factor in the replication of the hepatitis C virus (HCV). |
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T75153 |
ATL 1102
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ATL 1102 is a novel second-generation antisense oligonucleotide to CD49d mRNA |
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T37104 |
2’-OMe-G(ibu) Phosphoramidite
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2’-OMe-G(ibu) Phosphoramidite is a modified phosphoramidite monomer, which can be used for the oligonucleotide synthesis. |
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T74434 |
Apatorsen
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Apatorsen, an antisense oligonucleotide, targets Hsp27 mRNA to inhibit Hsp27 protein production by binding to it. |
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T17129 |
Tos-PEG3
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Others
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Tos-PEG3, a PEG-based PROTAC linker, is suitable for synthesizing PROTACs and 3'-aminooxy oligonucleotide solid supports[1]. |
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T74479 |
M7GpppUpG
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m7GpppUpG, an oligonucleotide and a trinucleotide cap analogue (M 7 GpppNpG), serves as a chemical tool for the production of RNA with either cap 0 or cap 1 structures [1]. |
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T39455 |
Viltolarsen
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NS-065,NCNP-01 |
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Viltolarsen (NS-065/NCNP-01) is a phosphorodiamidate morpholino antisense oligonucleotide that specifically targets the splicing of exon 53 in the dystrophin gene. It is utilized in research related to Duchenne muscular ... |
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T83297 |
5'6-FAM-UUCUCCGAACGUGUCACGUTT, ACGUGACACGUUCGGAGAATT
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5'6-FAM-UUCUCCGAACGUGUCACGUTT, ACGUGACACGUUCGGAGAATT is a fluorescein (FAM)-labeled oligonucleotide, denoted by the sequence provided. |
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T39650 |
Tadnersen
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IONIS-C9Rx,BIIB078 |
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Tadnersen (BIIB078) is an antisense oligonucleotide (ASO) designed for the selective targeting of C9ORF72 transcript variants 1 and 3, specifically those carrying the expansion. |
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T39294 |
Cobomarsen
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MRG-106,Cobomarsen |
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Cobomarsen (MRG-106) is an oligonucleotide inhibitor targeting miR-155. This compound effectively suppresses various gene pathways involved in cell survival, such as JAK/STAT, MAPK/ERK, and PI3K/AKT. Cobomarsen is partic... |
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T74433 |
Apatorsen sodium
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Apatorsen (sodium) is an antisense oligonucleotide that targets Hsp27 mRNA, effectively inhibiting the production of Hsp27 protein. |
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T38656 |
Nusinersen
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Nusinersen, an antisense oligonucleotide drug, modifies the pre-messenger RNA (pre-mRNA) splicing of the SMN2 gene, thereby enhancing the production of the full-length Survival Motor Neuron (SMN) protein. |
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T76238 |
Zilganersen
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Zilganersen (ION373), an antisense oligonucleotide functioning as a glial fibrillary acidic protein (GFAP) inhibitor, holds potential for research into Alexander disease (AxD) [1] [2]. |
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T74704 |
5'-ODMT cEt N-Bzm5 C Phosphoramidite (Amidite)
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5'-ODMT cEt N-Bzm5 C Phosphoramidite Amidite is a potent nucleic acid analog belonging to the class of modified antisense oligonucleotide [1]. |
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T38464 |
Miravirsen
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SPC-3649,Miravirsen |
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Miravirsen (SPC-3649), a β-d-oxy-locked nucleic acid-modified phosphorothioate antisense oligonucleotide, inhibit the biogenesis of miR-122 . Miravirsen (SPC-3649) is used in the study for HCV infections. |
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T40776 |
Diguanosine 5′-triphosphate
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Diguanosine 5′-triphosphate,Gp3G |
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Diguanosine 5′-triphosphate (Gp3G) is a kind of homodinucleotide from by GTP:GTP guanylyltransferase. Diguanosine 5′-triphosphate is a virus-specific oligonucleotide, can be used to prime reovirus transcription and inhib... |
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T39166 |
Tominersen
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IONIS-HTTRx,RG6042 |
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Tominersen (RG6042) is a second-generation 2′-O-(2-methoxyethyl) antisense oligonucleotide that targets huntingtin protein (HTT) mRNA and potently suppresses HTT production. Tominersen can be used for the research of Hun... |
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T39498 |
Tofersen
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BIIB067,ISIS-SOD1Rx |
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Tofersen (BIIB067) is an antisense oligonucleotide utilized to inhibit the synthesis of superoxide dismutase 1 (SOD1) protein by facilitating the degradation of SOD1 mRNA via the RNase H-dependent mechanism. This compoun... |
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T74842 |
Trecovirsen
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Trecovirsen (GEM91) is a 25-mer antisense phosphorothioate oligonucleotide that targets the gag site of the HIV gene. |
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TD0068 |
5(6)-ROX N-succinimidyl ester
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5(6)-ROX, SE [5-(and-6)-Carboxy-X-rhodamine, succinimidyl ester] *Mixed isomers* |
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5(6)-ROX, SE is an amine-reactive fluorescent probe that is widely used for oligonucleotide labeling and
automated DNA sequencing applications. |
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T74872 |
ODN 105870
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ODN 105870, a G-modified inhibitory oligonucleotide (INH-ODN), selectively inhibits TLR7 and is utilized in the research of inflammatory immune responses [1]. |
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T15074 |
DBCO-PEG4-TAMRA
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Others
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DBCO-PEG4-TAMRA, contains a DBCO group, is a PEG-based TARMA dye. The TAMRA dye is a dye widely used in oligonucleotide labeling. |
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T21096 |
Decamethylene glycol
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alpha,omega-Decanediol,Decamethylenediol,1,10-Dihydroxydecane,Decane-1,10-diol |
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Decamethylene glycol is a substance used as a reagent in the biological study of modified oligonucleotide with in vivo antitumoral activity. Also used in the pharmaceutical study on the composition of essential oils obta... |
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T75151 |
Aganirsen
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Aganirsen, a 25-mer DNA antisense oligonucleotide, silences the expression of insulin receptor substrate-1 (IRS-1). |
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TD0070 |
6-ROX, SE
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[6-Carboxy-X-rhodamine, succinimidyl ester] *Single isomer* |
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The isomeric 6-ROX, SE is an amine-reactive form of carboxy-X-rhodamine and is widely used for oligonucleotide labeling and automated DNA sequencing applications. |
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T74250 |
Custirsen
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Custirsen, a highly specific antisense oligonucleotide, inhibits the production of clusterin—an antiapoptotic protein upregulated in response to chemotherapy, thereby conferring treatment resistance. |
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T74691 |
Aprinocarsen sodium
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Aprinocarsen (ISIS 3521) sodium is a specific antisense oligonucleotide inhibitor targeting protein kinase C-alpha (PKC-α). It is a 20-mer oligonucleotide that modulates cell differentiation and proliferation. Demonstrat... |
