|
T39785L |
TH5427
|
|
NUDIX hydrolase
|
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TH5427 is a lead NUDT5 inhibitor(MG assay IC50 = 29 nM). |
|
T7537 |
Norgestimate
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|
Progesterone Receptor
|
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Norgestimate is an acetylated progestinused in combination with ethinyl estradiol as an oral contraceptive. |
|
T2567 |
Etonogestrel
|
3-Oxodesogestrel,3-keto-Desogestrel,Nexplanon,Implanon |
Estrogen Receptor/ERR
,
Estrogen/progestogen Receptor
,
Progesterone Receptor
,
Endogenous Metabolite
|
|
Etonogestrel (Implanon) is a steroidal progestin used as hormonal contraceptives. |
|
T8395 |
Nomegestrol acetate
|
|
Others
,
Progesterone Receptor
|
|
Nomegestrol acetate is a widely used progestin-like drug,which is characterized as a full agonist at the progesterone receptor |
|
T1541 |
Drospirenone
|
ZK 3059,Dihydrospirorenone |
Glucocorticoid Receptor
,
Estrogen/progestogen Receptor
,
Progesterone Receptor
,
Androgen Receptor
,
COX
|
|
Drospirenone (ZK 3059) is a synthetic spironolactone analogue and progestin with progestational and anti-mineralocorticoid activity. |
|
T5174 |
Nestoron
|
ST-1435,Segesterone Acetate,Nestorone,Elcometrine |
Estrogen/progestogen Receptor
,
Progesterone Receptor
|
|
Nestoron (Segesterone Acetate), a synthetic progestin, is a high-affinity agonist of the progesterone receptor (EC50: 10.3 nM). |
|
T1102 |
Mifepristone
|
C-1073,RU486,RU 38486 |
Glucocorticoid Receptor
,
Estrogen/progestogen Receptor
,
Progesterone Receptor
,
NO Synthase
,
Autophagy
|
|
Mifepristone (C-1073) is a Progestin Antagonist. The mechanism of action of mifepristone is as a Progestational Hormone Receptor Antagonist. |
|
T2597 |
Norgestrel
|
SH-850,FH 122-A,WY-3707,SH-70850 |
Estrogen/progestogen Receptor
,
Reactive Oxygen Species
|
|
Norgestrel (WY-3707) is a synthetic progestin commonly used alone or in combination with an estrogen for contraception. Norgestrel suppresses the secretion of luteinizing and follicle-stimulating hormones (LH and FSH), t... |
|
T33819 |
Org 2058
|
O-2058,Org-2058,Org2058 |
|
|
Org 2058 is a synthetic progestin. |
|
T30942 |
Cingestol
|
|
|
|
Cingestol is a steroidal progestin of the 19-nortestosterone group that was never marketed. |
|
T29248 |
(+)-Norgestrel
|
Dextronorgestrel,L-Norgestrel |
|
|
(+)-Norgestrel is a progestin medication for the treatment of birth control pills and in menopausal hormone therapy. |
|
T34141 |
Promegestone
|
R5020,R-5020,RU 5020,R 5020,RU-5020 |
|
|
Promegestone is a progestin medication used in menopausal hormone therapy and in the treatment of gynecological disorders. |
|
T19811 |
Nomegestrol
|
|
|
|
Nomegestrol is a progestin. It is used in the treatment of gynecological disorders, in menopausal hormone therapy for the treatment of menopausal symptoms, and in hormonal contraceptives. |
|
T25304 |
Demegestone
|
R-2453,Lutionex,R 2453,RU 2453,R2453 |
|
|
Demegestone is a progestin, or a synthetic progestogen, and hence is a progesterone receptor agonist, the biological target of progestogens like progesterone. It has no androgenic activity. Previously used to treat lutea... |
|
T28280 |
Oxendolone
|
Roxenone,Prostetin |
|
|
Oxendolone is a steroidal progestin and antiandrogen. Oxendolone binds to the progesterone receptor (Ki = 20 nM) and androgen receptor (AR) (Ki = 320 nM) and acts as a weak but clinically relevant inhibitor of 5α-reducta... |
|
T34302 |
Retroprogesterone
|
|
|
|
Retroprogesterone, a progestin, may be used for menstrual irregularities in adolescence, for the maintenance of threatened pregnancy, and possibly as an ovulation stimulant. |
|
T13763 |
LY88074 analog 1
|
|
Others
|
|
LY88074 analog 1, a benzothiophene compound with nitrogen-containing non-basic side chains, can be utilized either independently or alongside estrogen or progestin. This agent is effective for mitigating post-menopausal ... |
|
T19697 |
Norgestomet
|
SC21009,Norprogesterone, Syncro-Mate B,SC-21009,SC 21009 |
|
|
Norgestomet is a steroidal progestin of the 19-norprogesterone group used in veterinary medicine to control estrus and ovulation in cattle. In addition to the progesterone receptor, norgestomet possesses a weak (micromol... |
|
T37647 |
5α-dihydro Levonorgestrel
|
|
|
|
5α-dihydro Levonorgestrel is a metabolite of the synthetic progestin levonorgestrel . It lacks in vitro and in vivo estrogenic activity, but induces copulatory behavior in male rats when administered at a dose of 1 mg pe... |
|
T5317L |
Cridanimod sodium
|
XBIO-101,XBIO 101,Cycloferon,Sodium Cridanimod,Cridanimod Na,XBIO101 |
|
|
Cridanimod can increase progesterone receptor (PR) expression, with potential antineoplastic adjuvant activity. Cridanimod is able to induce the expression of PR in endometrial cancer. In combination with a progestin, ca... |
|
T39785 |
TH5427 hydrochloride
|
|
|
|
TH5427 hydrochloride is a potent and selective inhibitor of NUDT5 with an IC50 of 29 nM. It demonstrates a remarkable 690-fold selectivity towards NUDT5 compared to MTH1. Moreover, TH5427 hydrochloride effectively inhibi... |
|
T83666 |
Kisspeptin-10 (zebrafish) TFA
|
Tyr-Asn-Leu-Asn-Ser-Phe-Gly-Leu-Arg-Tyr-NH2,Kp-10 |
|
|
Kisspeptin-10, a neuropeptide present in the brains, ovaries, and testes of zebrafish, plays a critical role in gonadal development and steroid expression. At a concentration of 10 ng/ml, it enhances the mRNA levels for ... |
