検索結果

Search Results for " retina "

ターゲット

阻害剤

天然化合物

リコンビナントタンパク質

ライブラリー

カタログ番号	製品名	別名	ターゲット
T22733	DL-AP5		NMDAR
	DL-AP5 is the racemic form of a selective N-methyl-D-aspartate (NMDA) receptor antagonist with anticonvulsant effects.		NMDAR
T6831	Etretinate	Retinoid,Tegison,Etretinato,Ethyl etrinoate,Ro 10-9359	Apoptosis , Others
	Etretinate (Ro 10-9359) is an oral aromatic retinoid acid which is effective in psoriasis and other dermatological syndromes. It activates retinoid receptors, causing an induction of cell differentiation, inhibition of c...		Apoptosis , Others
T29395	3-Diazirinophenylretinal		Others
	3-Diazirinophenylretinal is a bioactive chemical.		Others
T38219	11-cis Retinal		Others
	11-cis Retinal is a chromophore that binds to opsin in the mammalian visual system as an inverse agonist forming the inactive conformation of rhodopsin. When 11-cis retinal absorbs a photon of light, it isomerizes to for...		Others
T34299	Retinaloxime	trans-Retinaloxime	Others
	Retinaloxime is a retinoid.		Others
T8600	N-ACETYLTRYPTAMINE		Melatonin Receptor
	N-ACETYLTRYPTAMINE is a partial agonist for melatonin receptors in the retina. Also used for determination of serotonin N-acetyl transferase.		Melatonin Receptor
T41321	Docosahexaenoic acid ethyl ester	Ethyl docosahexaenoate	Dopamine Receptor
	Docosahexaenoic acid ethyl ester (Ethyl docosahexaenoate) enhances 6-hydroxydopamine-induced neuronal damage by inducing lipid peroxidation in the mouse striatum, and can be used to study oxidative diseases of the retina...		Dopamine Receptor
T8736	Cidofovir dihydrate	HPMPC,(S)-HPMPC,GS 0504	Others
	Cidofovir dihydrate (HPMPC) is an anti-CMV drug, It can suppress CMV replication by selective inhibition of viral DNA polymerase and therefore prevention of viral replication and transcription. Cidofovir dihydrate is an ...		Others
T22530	6-Chloromelatonin		Melatonin Receptor , Dopamine Receptor
	6-Chloromelatonin is a potent melatonin receptor agonist, a 5-methoxyindole compound that competes for the same presynaptic melatonin receptor sites in the rabbit retina and inhibits the calcium-dependent release of [3H]...		Melatonin Receptor , Dopamine Receptor
T84497	CAY10632		Others
	Very long chain polyunsaturated fatty acids (VLCPUFA), notably present in the retina, sperm, and brain, have yet to be fully understood in terms of their biosynthesis and functional roles within these tissues. Recent res...		Others
T85016	1-Palmitoyl-2-Arachidonoyl-sn-glycero-3-PE	1-Hexadecanoyl-2-Eicosatetraenoyl-sn-glycero-3-Phosphatidylethanolamine	Others
	1-Palmitoyl-2-arachidonoyl-sn-glycero-3-PE, a phospholipid comprising palmitic acid and arachidonic acid at the sn-1 and sn-2 positions respectively, is identified in egg yolk and isolated rat retina.		Others
T68125	(Rac)-PD0299685	(Rac)-PF-299685	Calcium Channel
	(Rac)-PD0299685 is a potent voltage-dependent calcium channel inhibitor for the study of retina-related diseases.		Calcium Channel
T38216	1-Palmitoyl-2-Oleoyl-3-Arachidonoyl-rac-glycerol		Others
	1-Palmitoyl-2-oleoyl-3-arachidonoyl-rac-glycerol is a triacylglycerol that contains palmitic acid , oleic acid , and arachidonic acid at the sn-1, sn-2, and sn-3 positions, respectively. It has been found in lipid extrac...		Others
T35505	(±)11-HDHA		Others
	(±)11-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro. It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes. DHA is metabolized to 11(S)-HDHA by human platelet...		Others
T36607	(±)8-HDHA		Others
	(±)8-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro. It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes. (±)8-HDHA is a potential marker of oxidative stress...		Others
T35512	(±)16-HDHA		Others
	(±)16-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro. It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes. (±)16-HDHA is a potential marker of oxidative stre...		Others
T78197	5-Fluoromethylornithine dihydrochloride	5-FMOrn dihydrochloride	Others
	5-Fluoromethylornithine (5-FMOrn) dihydrochloride is a specific, irreversible inhibitor of L-ornithine:2-oxoacid aminotransferase (OAT), utilized in research pertaining to gyrate atrophy of the choroid and retina [1] [2]...		Others
T35508	(±)13-HDHA		Others
	(±)13-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro. It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes. Fresh water hydra was shown to metabolize DHA to 1...		Others
T37532	Docosahexaenoyl Glycine
	The ω-3 polyunsaturated fatty acids (PUFAs) found in fish oils provide cardiovascular benefits. Docosahexaenoic acid (DHA), a C22:6 PUFA, is the most abundant ω-3 fatty acid in neural tissues, especially in the retina an...
TP1464	Risuteganib hydrochloride
	Risuteganib hydrochloride is an anti-integrin that downregulates oxidative stress and restores homeostasis, and targets three integrin receptors that are implicated in dry age-related macular degeneration (AMD) in order ...
T36606	(±)7-HDHA		Others
	(±)7-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro. It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes. Enzymatic transformation of DHA by RBL-1 cells and ...		Others
T36602	(±)4-HDHA		Others
	(±)4-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro. It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes. Enzymatic transformation of DHA by RBL-1 cells also...		Others
TP2199	Rhodopsin peptide		Others
	Rhodopsin peptide is a peptide with the sequence H2N-Val-Ser-Lys-Thr-Glu-Thr-Ser-Gln-Val-Ala-Pro-Ala-OH, MW= 1217.33. Rhodopsin is a biological pigment in photoreceptor cells of the retina that is responsible for the fir...		Others
T81311	RASP-IN-1		Others
	RASP-IN-1 (Compound A), a lipophilic compound, serves as an inhibitor for macular degeneration and exhibits biological activity within the rabbit retina. In a mouse model [1], the administration of 14 C-RASP-IN-1 (10 mg/...		Others
TP1749	IRBP (1-20), human
	IRBP (1-20), human is the 1-20 fragment of interphotoreceptor retinoid binding protein (IRBP).This peptide is a 1 to 20 amino acid fragment of the interphotoreceptor retinoid binding protein (IRBP). IRBP is a 140-kDa gly...
T37259	14(S)-HDHA		Others
	Docosahexaenoic acid is a nutritionally-derived ω-3 fatty acid that is abundant in the brain and the retina and is thought to be important in early development and for therapeutic approaches to inflammatory disorders and...		Others
T35504	(±)10-HDHA		Others
	(±)10-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro.[1][2] It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes.[3][4][5] (±)10-HDHA is a potential marker of...		Others
T36601	(±)17-HDHA		Others
	(±)17-HDHA is an autoxidation product of docosahexaenoic acid in vitro. It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes. 17(S)-HDHA could be produced by enzymatic oxidation of D...		Others
T37503	Maresin 2	3R,14S-diHDHA	Others
	Docosahexaenoic acid is an ω-3 fatty acid that is abundant in the brain and the retina and is known to be important in early development.[1] [2] Maresin 2 (MaR2) is a 13R,14S-dihydroxy DHA formed by recombinant human mac...		Others
T35497	(±)7(8)-EpDPA		Others
	Docosahexaenoic acid is the most abundant ω-3 fatty acid in neural tissues, especially in the brain and retina. (±)7(8)-EpDPA is an epoxide derivative of DHA that is generated by the action of cytochrome P450 epoxygenase...		Others
T35509	(±)14-HDHA		Others
	(±)14-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro. It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes. DHA is metabolized to 14(S)-HDHA by human platelet...		Others
T35578	Phosphatidylserines (sodium salt)	Phosphatidylserines (sodium salt),L-α-Phosphatidylserine	Others
	Phosphatidylserine is a naturally occurring phospholipid that comprises 2-10% of total phospholipids in mammals and is enriched in the central nervous system, particularly the retina. It is anionic and found mainly on th...		Others

Compounds

Synonym: Retinoid,Tegison,Etretinato,Ethyl etrinoate,Ro 10-9359

Target: Apoptosis, Others

3-Diazirinophenylretinal

Synonym: trans-Retinaloxime

Target: Melatonin Receptor

Docosahexaenoic acid ethyl ester

T41321

Synonym: Ethyl docosahexaenoate

Target: Dopamine Receptor

Cidofovir dihydrate

T8736

Synonym: HPMPC,(S)-HPMPC,GS 0504

Target: Melatonin Receptor, Dopamine Receptor

1-Palmitoyl-2-Arachidonoyl-sn-glycero-3-PE

T85016

Synonym: 1-Hexadecanoyl-2-Eicosatetraenoyl-sn-glycero-3-Phosphatidylethanolamine

Target: Others

(Rac)-PD0299685

T68125

Synonym: (Rac)-PF-299685

Target: Calcium Channel

1-Palmitoyl-2-Oleoyl-3-Arachidonoyl-rac-glycerol

5-Fluoromethylornithine dihydrochloride

T78197

Synonym: 5-FMOrn dihydrochloride

Docosahexaenoyl Glycine

T37532

Synonym:

Target:

Risuteganib hydrochloride

Synonym: 3R,14S-diHDHA

Phosphatidylserines (sodium salt)

T35578

Synonym: Phosphatidylserines (sodium salt),L-α-Phosphatidylserine

Target: Others

カタログ番号	製品名	別名	ターゲット
T5256	All-trans-retinal	All trans-Retinal,Retinaldehyde,Vitamin A aldehyde	Others , Endogenous Metabolite
	All-trans-retinal (Vitamin A aldehyde) is a one of the major vitamin A metabolites in the retina. All-trans-RAL is regenerated to the visual chromophore, 11-cis-retinal in physiological conditions.		Others , Endogenous Metabolite
T19169	9-cis-Retinal		Others
			Others
T0937	Riboflavin	Vitamin B2,E101	Endogenous Metabolite
	Riboflavin (E101) is a micronutrient that occurs in the free form only in the retina of the eye, in whey, and in urine; its principal forms in tissues and cells are as flavin mononucleotide and flavin-adenine dinucleotid...		Endogenous Metabolite
T5369	Docosahexaenoic Acid	Cervonic acid,DHA	Others , Endogenous Metabolite
	Docosahexaenoic Acid (DHA) is an essential fatty acid and an omega-3 fatty acid abundant in brain and retina.		Others , Endogenous Metabolite
T3394	Timosaponin BII	Prototimosaponin A III	Beta Amyloid , Others , BACE
	Timosaponin BII (Prototimosaponin A III) has anti-dementia activity and may be useful for the treatment of type 2 diabetes. Timosaponin BII has antioxidant activity, can inhibit the up-regulation of BACE1 and reduced the...		Beta Amyloid , Others , BACE
T1183	Retinol	all-trans-Retinol,Vitamin A,Vitamin A1,Alphalin	Others
	Retinol (Alphalin) and derivatives of retinol that play an essential role in metabolic functioning of the retina, the growth of and differentiation of epithelial tissue, the growth of bone, reproduction, and the immune r...		Others
T4S0969	Obtusifolin		Antioxidant , NF-κB
	1. Obtusifolin has antioxidant properties and improves chemically induced diabetes and its complications by modulation of oxidative stress. 2. Obtusifolin suppresses phthalate esters-mediated bone resorption, thus may be...		Antioxidant , NF-κB
T35577	Phosphatidylserines (bovine)		Others
	Phosphatidylserine is a naturally occurring phospholipid that comprises 2-10% of total phospholipids in mammals and is enriched in the central nervous system, particularly the retina. It is anionic and found mainly on th...		Others

天然物製品

All-trans-retinal

T5256

Synonym: All trans-Retinal,Retinaldehyde,Vitamin A aldehyde

Target: Others, Endogenous Metabolite

Synonym: Vitamin B2,E101

Target: Endogenous Metabolite

Docosahexaenoic Acid

T5369

Synonym: Cervonic acid,DHA

Target: Others, Endogenous Metabolite

Timosaponin BII

T3394

Synonym: Prototimosaponin A III

Target: Beta Amyloid, Others, BACE

Retinol

T1183

Synonym: all-trans-Retinol,Vitamin A,Vitamin A1,Alphalin

Target: Antioxidant, NF-κB

Phosphatidylserines (bovine)

T35577

Synonym:

Target: Others

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPH-02804	NRL Protein, Mouse, Recombinant (His & Myc & SUMO)	Mouse	E. coli
	Acts as a transcriptional activator which regulates the expression of several rod-specific genes, including RHO and PDE6B. Functions also as a transcriptional coactivator, stimulating transcription mediated by the transc...
TMPH-01755	NRL Protein, Human, Recombinant (His & Myc)	Human	E. coli
	Acts as a transcriptional activator which regulates the expression of several rod-specific genes, including RHO and PDE6B. Functions also as a transcriptional coactivator, stimulating transcription mediated by the transc...
TMPY-03554	GCAP1 Protein, Human, Recombinant	Human	Baculovirus Insect Cells
	GCAP1 Protein, Human, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 23.1 kDa and the accession number is P43080.
TMPY-03463	GCAP1 Protein, Human, Recombinant (His & GST)	Human	Baculovirus Insect Cells
	GCAP1 Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 50.7 kDa and the accession number is P43080.
TMPJ-00842	FGF-2 Protein, Rat, Recombinant	Rat	E. coli
	FGF-basic is a members of the Fibroblast Growth Factors (FGFs) family. The family constitutes a large family of proteins involved in many aspects of development including cell proliferation, growth, and differentiation. ...
TMPJ-00945	HPCAL1 Protein, Human, Recombinant (His)	Human	E. coli
	Hippocalcin-Like Protein 1 (HPCAL1) is a neuron-specific calcium-binding member of the recoverin family which found in the retina and brain. HPCAL1 contains four EF-hand domains and it is highly similar to human hippocal...
TMPH-02888	SFRP5 Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP5 may be ...
TMPJ-01299	RTBDN Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Human Retbindin is a 229 amino acid secreted protein that belongs to the folate receptor family. The gene that encodes retbindin exists as two alternatively spliced isoforms. Retbindin is first expressed in retina. It ma...
TMPJ-01134	CLUL1 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Clusterin-Like Protein 1 (CLUL1) is a secreted protein that belongs to the clusterin family. CLUL1 is synthesized as a 466 amino acid precursor that contains a 20 amino acid signal sequence, and a 446 amino acid mature c...
TMPY-02955	CABP5 Protein, Human, Recombinant (His)	Human	E. coli
	CABP3, also known as CABP5, belongs to a subfamily of calcium binding proteins, which share similarity to calmodulin. Calcium binding proteins are an important component of calcium mediated cellular signal transduction. ...
TMPJ-00265	Serpin F1 Protein, Mouse, Recombinant	Mouse	E. coli
	Serpin F1 is secreted Neurotrophic protein and belongs to the serpin family. Serpin F1 Highly expressed in the liver, gastric glandular mucosa and renal tubules. It is also expressed in the brain, heart, lung retina and ...
TMPJ-00706	SNCG Protein, Human, Recombinant	Human	E. coli
	Gamma-Synuclein (SNCG) is a member of the Synuclein protein family. Gamma-Synuclein is mostly expressed in the peripheral nervous system and retina. Gamma-Synuclein plays a role in neurofilament network integrity and may...
TMPJ-01398	ITM2B Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Integral Membrane Protein 2B (ITM2B) is expressed in the Golgi and on the cell surface. ITM2B forms homodimer through disulfide-linked interaction with SPPL2A, SPPL2B and APP. ITM2B is expressed in brain and the other ti...
TMPY-02438	AKR1B1 Protein, Human, Recombinant (His)	Human	E. coli
	Aldose reductase (AKR1B1) belongs to the aldo/keto reductase superfamily. AKR1B1 is a NADPH-dependent aldo-keto reductase best known as the rate-limiting enzyme of the polyol pathway. Expression of AKR1B1 was the highest...
TMPJ-01130	NPTX1 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Neuronal Pentraxin (NPTX1, NP1) is a secreted glycoprotein within the Pentraxin family. NPTX1 is co‑expressed and forms heteromultimers with the related secreted protein, NPTX2/NARP, NPTXR (Neuronal Pentraxin Receptor) a...
TMPJ-00916	TIMP-2 Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	Mouse Metalloproteinase inhibitor 2(TIMP-2), belongs to a family of proteins that regulate the activation and proteolytic activity of matrix metalloproteinases (MMPs). There are four mammalian members of the family; TIMP...
TMPJ-00715	FGF-19 Protein, Human, Recombinant (His)	Human	E. coli
	Fibroblast growth factor 19 (FGF19) is a secreted protein which belongs to the FGFs family. FGF19 is expressed in fetal brain, cartilage, retina, and adult gall bladder. FGFs modulate cellular activity via at least 5 dis...
TMPY-04761	Creatine kinase B Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	CKB(Creatine kinase B type) contains 1 phosphagen kinase C-terminal domain and 1 phosphagen kinase N-terminal domain. It belongs to the ATP:guanido phosphotransferase family. CKB consists of a homodimer of two identical...
TMPJ-00821	OM Protein, Human, Recombinant (His)	Human	E. coli
	Oncomodulin-1 (OM) is a small, calcium-binding protein and a macrophage-derived growth factor, which can promote axon regeneration in retinal ganglion cells. Oncomodulin-1 is constitutively secreted by activated macropha...
TMPJ-00292	CD36 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	Platelet Glycoprotein 4 (CD36) is an integral membrane glycoprotein that has multiple physiological functions. It is broadly expressed on a variety of cell types including microvascular endothelium, adipocytes, skeletal ...
TMPY-01052	R-Cadherin/CDH4 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	The cadherin superfamily is a large family that engage in both homo- and heterotypic, calcium-dependent, cell-cell adhesion events, and can be divided into at least four subfamilies based on the extracellular (EC) region...
TMPY-02248	Myocilin Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Myocilin, also known as Trabecular meshwork-induced glucocorticoid response protein, MYOC, and GLC1A, is a protein that contains one olfactomedin-like domain. Myocilin / MYOC may participate in the obstruction of fluid o...
TMPY-02289	CIB2 Protein, Human, Recombinant (His)	Human	E. coli
	Calcium and integrin-binding protein 2 (CIB2) belongs to a protein family with four known members, CIB1 through CIB4, which are characterized by multiple calcium-binding EF-hand domains. Sensorineural hearing loss is gen...