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Search Results for " retinoblastoma "

ターゲット

阻害剤

天然化合物

リコンビナントタンパク質

カタログ番号	製品名	別名	ターゲット
T15648	KDM5-C70		Histone Demethylase
	KDM5-C70 is an ethyl ester derivative of KDM5-C49. KDM5-C70 is an effective, cell-permeable, and pan-KDM5 histone demethylase inhibitor. KDM5-C70 has an antiproliferative effect in myeloma cells, inducing a genome-wide e...		Histone Demethylase
T8350	TPCK		Proteasome
	TPCK is an irreversible inhibitor of chymotrypsin-like proteases that affect cell proliferation, apoptosis, and tumorigenesis		Proteasome
T7698	BS194		CDK
	BS194 is as a potent cyclin-dependent protein kinases (CDKs) inhibitor.		CDK
T9636	Dalpiciclib	SHR-6390	CDK
	Dalpiciclib (SHR-6390) is a highly selective, orally bioavailable, and comparable potency inhibitor of CDK4 and CKD6 with IC50s of 12.4 nM and 9.9 nM, respectively. Dalpiciclib exerts potent antitumor activity in esophag...		CDK
T21314	Amsilarotene	TAC-101,TAC 101,TAC101	CDK
	Amsilarotene (TAC101) inhibits the phosphorylation of retinoblastoma gene product (RB) and increases the presence of 2 cyclin-dependent kinases (CDK) inhibitors resulting in cell cycle arrest. This agent also causes a cy...		CDK
T26855	BMS-665053	BMS665053
	BMS-665053 is a corticotropin-releasing factor-1 (CRF1) receptor antagonist (IC50 = 1.0 nM). BMS-665053)11 is a potent inhibitor of CRF-stimulated cyclic adenosine monophosphate (cAMP) production in human Y-79 retinoblas...
T26456	A 83586C	A83586C,A-83586C
	A-83586C is a depsipeptide antibiotic from Streptomyces karnatakensis with potent against Gram-positive activity in vitro. A-83586C acts as a highly potent inhibitor of beta-catenin/TCF4 signaling within cancer cells, wh...
T62235	CDK-IN-9
	CDK-IN-9 (compound 24) is a potent inhibitor of CDK. CDK-IN-9 is also a molecular gel that induces interaction between CDK12 and DDB1 and is able to act on CDK2/E (IC50: 4 nM). CDK-IN-9 can be used to dephosphorylate ret...
T69196	AG-012986
	AG-012986 is a multitargeted cyclin-dependent kinase (CDK) inhibitor active against CDK1, CDK2, CDK4/6, CDK5, and CDK9, with selectivity over a diverse panel of non-CDK kinases. AG-012986 showed antiproliferative activit...
T70377	BAY 61-3606 HCl
	BAY 61-3606 HCl is a cell-permeable, reversible inhibitor of spleen tyrosine kinase. BAY 61-3606 HCl can inhibit degranulation and block cytokine release from mast cells. Oral administration of BAY 61-3606 to rats was sh...
T72928	CDK4/6-IN-15
	CDK4/6-IN-15, an orally active and selective inhibitor of CDK4/6, effectively halts the growth of cancer cells by arresting the cell cycle at the G1 phase and inhibiting the phosphorylation of the retinoblastoma tumor su...
T69197	AG-012986 HCl
	AG-012986 HCl is a multitargeted cyclin-dependent kinase (CDK) inhibitor active against CDK1, CDK2, CDK4/6, CDK5, and CDK9, with selectivity over a diverse panel of non-CDK kinases. AG-012986 HCl showed antiproliferative...

Compounds

KDM5-C70

T15648

Synonym:

Target: Histone Demethylase

Synonym: TAC-101,TAC 101,TAC101

Synonym: A83586C,A-83586C

カタログ番号	製品名	別名	ターゲット
T6S1917	Schisandrol B	Gomisin A,TJN-101,Besigomsin,Gamma-Schisandrin,Schizandrol B,Wuweizi alcohol-B	P450 , Reactive Oxygen Species , Autophagy
	1. Schisandrol B (Besigomsin) may exert neuroprotective effects by attenuating the microglia-mediated neuroinflammatory response via inhibiting the TLR4-mediated NF-κB and MAPKs signaling pathways. 2. Schisandrol B has a...		P450 , Reactive Oxygen Species , Autophagy
T72100	D-erythro-Sphingosine hydrochloride	Erythrosphingosine hydrochloride,trans-4-Sphingenine hydrochloride,erythro-C18-Sphingosine hydrochloride,Erythrosphingosine hydrochloride ; erythro-C18-Sphingosine hydrochloride ; trans-4-Sphingenine hydrochloride
	D-erythro-Sphingosine hydrochloride, also known as Erythrosphingosine, serves as a specific TRPM3 activator and induces retinoblastoma protein dephosphorylation.
T4110	Perivine	Perivin	Others
	Perivine (Perivin) may resolve the instability of the retinoblastoma-associated proteins (RbAp48) complex and thus be used in Alzheimer's disease therapy. Perivine, vobasine, coronaridine and dichomine show hypotensive a...		Others

天然物製品

Schisandrol B

T6S1917

Synonym: Gomisin A,TJN-101,Besigomsin,Gamma-Schisandrin,Schizandrol B,Wuweizi alcohol-B

Target: P450, Reactive Oxygen Species, Autophagy

D-erythro-Sphingosine hydrochloride

T72100

Synonym: Erythrosphingosine hydrochloride,trans-4-Sphingenine hydrochloride,erythro-C18-Sphingosine hydrochloride,Erythrosphingosine hydrochloride ; erythro-C18-Sphingosine hydrochloride ; trans-4-Sphingenine hydrochloride

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPY-05251	RbAp48 Protein, Mouse, Recombinant (His)	Mouse	Baculovirus Insect Cells
	RbAp48 Protein, Mouse, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 50 kDa and the accession number is Q09028-1.
TMPY-01713	RbAp48 Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	RbAp48 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 50 kDa and the accession number is Q09028-1.
TMPH-00975	DDX1 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	DDX1 Protein, Human, Recombinant (His & Myc) is expressed in E. coli.
TMPH-00989	ARID4B Protein, Human, Recombinant (His)	Human	E. coli
	ARID4B Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 32.8 kDa and the accession number is Q4LE39.
TMPY-04548	CDK4 Protein, Human, Recombinant (GST)	Human	Baculovirus Insect Cells
	CDK4 is a member of the Ser/Thr protein kinase family. It is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cel...
TMPJ-00265	Serpin F1 Protein, Mouse, Recombinant	Mouse	E. coli
	Serpin F1 is secreted Neurotrophic protein and belongs to the serpin family. Serpin F1 Highly expressed in the liver, gastric glandular mucosa and renal tubules. It is also expressed in the brain, heart, lung retina and ...
TMPJ-00703	Gankyrin Protein, Human, Recombinant	Human	E. coli
	Gankyrin is a multicatalytic proteinase oncoprotein consists of 7 ankyrin repeats. Gankyrin overexpressed in most hepatocellular carcinomas. Gankyrin is involved in theregulation of the phosphorylation of the retinoblast...
TMPJ-00459	Esterase D Protein, Human, Recombinant (His)	Human	E. coli
	Human Esterase D is a cytoplasmic serine hydrolase that belongs to the esterase D family. Esterase D is involved in the detoxification of formaldehyde. Esterase D plays a part in a variety of substrates, including O-acet...
TMPY-03391	ESD Protein, Human, Recombinant (His)	Human	E. coli
	Esterase D, also known as ESD, is a serine hydrolase that belongs to the esterase D family. Esterase D is active toward numerous substrates including O-acetylated sialic acids, and it may be involved in the recycling of ...
TMPJ-00963	CDKN2C Protein, Human, Recombinant (His)	Human	E. coli
	Cyclin-Dependent Kinase 4 Inhibitor C (CDKN2C) is a member of the INK4 family of cyclin dependent kinase inhibitors. CDKN2C contains 4 ANK repeats and interacts with CDK4 or CDK6. Highest levels of CDKN2C can be found in...
TMPY-02495	P19 INK4d Protein, Human, Recombinant (GST)	Human	E. coli
	Cyclin-dependent kinase inhibitor 2D(also known as CDKN2D or p19ink4d), a member of the INK4 family of cyclin-dependent kinase (CDK) inhibitors, negatively regulates the cyclin D-CDK4/6 complexes, which promote G1/S tran...
TMPY-01711	Serpin B2 Protein, Human, Recombinant (GST)	Human	Baculovirus Insect Cells
	Serpins are the largest and most diverse family of serine protease inhibitors which are involved in some fundamental biological processes such as blood coagulation, complement activation, fibrinolysis, angiogenesis, infl...
TMPJ-00936	CCND2 Protein, Human, Recombinant (His)	Human	E. coli
	CCND2，also known as G1/S-specific cyclin-D2，is a member of the highly conserved cyclin family. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each ...