|
T6085 |
PF-543
|
Sphingosine Kinase 1 Inhibitor II,PF 543 |
Apoptosis
,
S1P Receptor
,
Autophagy
,
LPL Receptor
|
|
PF-543 (Sphingosine Kinase 1 Inhibitor II), a novel sphingosine-competitive inhibitor of SphK1, inhibits SphK1 with IC50 and Ki of 2.0 nM and 3.6 nM. |
|
TQ0138 |
K145 hydrochloride
|
|
Apoptosis
,
S1P Receptor
|
|
|
|
T8840 |
PF-543 hydrochloride
|
PF-543 |
Apoptosis
,
S1P Receptor
,
Autophagy
,
LPL Receptor
|
|
PF-543 hydrochloride (PF-543) inhibits SphK1 with a K(i) of 3.6 nM, is sphingosine-competitive and is more than 100-fold selective for SphK1 over the SphK2 isoform. |
|
T16128 |
MP-A08
|
|
S1P Receptor
|
|
MP-A08 is a highly selective ATP competitive inhibitor of sphingosine kinase (SPHK1) that targets both SphK1 and SphK2 (Ki: 6.9 ± 0.8 μM and 27 ± 3 μM, respectively). |
|
T12436 |
PF-543 Citrate
|
Sphingosine Kinase 1 Inhibitor II Citrate |
S1P Receptor
|
|
PF-543 Citrate is an inhibitor of sphingosine-competitive SPHK1(IC50 of 2 nM ). |
|
T70816 |
(R)-FTY720-OMe
|
|
|
|
(R)-FTY720-OMe is a structural analogue of FTY720 which acts as a specific competitive inhibitor of sphingosine kinase 2 (SK2). Furthermore, (R)-FTY720-OMe does not inhibit sphingosine kinase 1 (SK1) activity. |
|
T60798 |
SK1- I hydrochloride
|
|
|
|
SK1-I hydrochloride (BML-258 hydrochloride) is a sphingosine analog that can enhance autophagy and has antitumor activity. SK1-I hydrochloride is an isozyme-specific competitive SPHK1 inhibitor (Ki = 10 μM) [1] [2]. |
