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Search Results for " synovial "

ターゲット

16

阻害剤

4

天然化合物

17

リコンビナントタンパク質

カタログ番号 製品名 別名 ターゲット
T8550 NDMC101 Others , NF-κB , Proteasome
NDMC101 is an inhibitor of dipeptidyl peptidase-IV activity in human T cells and exhibits immunomodulatory effects. It also acts as a novel inhibitor of NFATc1 and NF-κB activity.
T4282 S-methyl-KE-298 MMP , Drug Metabolite
S-methyl-KE-298 is the second main metabolite in plasma,is a methyl conjugate of deacetyl-KE-298.KE-298 inhibits matrix metalloproteinase (MMP-1) production from  rheumatoid arthritis (RA) synovial cells.
T31751 Fce 21258 Ddh-carbo pgl2
Fce 21258 is used to stimulate the adenylate cyclase of synovial fluid macrophages.
T19771 SXT1596 NSC-65667,SXT-1596,NSC 65667,SXT 1596,NSC65667
SXT1596 is a novel SS18-SSX/TLE1 interaction inhibitor. SXT1596 reduces cell viability and reactivates EGR1 expression in synovial sarcoma.
T35480 DBRD9-A dBRD9-A
Potent BRD9 degrader. Selectively binds BRD9 and elicits near complete degradation of BRD9 at nanomolar concentrations. Inhibits growth of synovial sarcoma cells in vitro and tumor progression in a synovial sarcoma xeno...
T70230 FPTI
FPTI is an inhibitor against SYT-SSX1 fusion protein in synovial sarcoma which down-regulates SYT-SSX1 and modulates its downstream target genes.
T82239 HAP-1
HAP-1, a synovial-targeted transduction peptide, selectively mediates the internalization of protein complexes into synovial cells of human and rabbit origin. When fused with the antimicrobial peptide (KLAK)2, HAP-1 form...
T68344 AGG-523
AGG-523 is an aggrecanase specific inhibitor that has been shown to attenuate increases in synovial fluid ARG-aggrecan levels following surgically-induced joint instability in the rat MT model. Pharmacologic inhibition o...
T76989 Tabituximab barzuxetan
Tabituximab barzuxetan (OTSA101-DTPA-90Y) is a radioimmunoconjugate composed of a humanized monoclonal antibody targeting FZD-10 (OTSA-101) , and labeled with Yttrium 90. Tabituximab barzuxetan shows antineoplastic acti...
T70834 BE-16627B
BE-16627B is a novel metalloproteinase (MP) inhibitor isolated from Streptomyces sp. BE16627B selectively inhibited MPs such as human stromelysin and 92 kD gelatinase. After the cells were cultured with BE16627B for 5 da...
T71525 AB05831
AB05831, also known as 2-Acetamido-1,2-dideoxynojirimycin, is a highly potent and specific inhibitor of beta-hexosaminidase. N-Acetyl-3-hexosaminidase (HEX) is a member of lysosomal hydrolases, which catalyzes hydrolysis...
T38143 Elaidamide
Elaidamide is a fatty acid amide that has been found in the cerebrospinal fluid of sleep-deprived cats.1 It inhibits rat microsomal epoxide hydrolase (mEH; Ki = 70 nM).2 Elaidamide also inhibits porcine pancreatic and hu...
T37606 Resolvin D5 7(S),17(S)-diHDHA
Resolvins are a family of potent lipid mediators derived from both eicosapentaenoic acid and docosahexaenoic acid . [1] In addition to being anti-inflammatory, resolvins promote the resolution of the inflammatory respons...
T60979 Oxaprozin potassium
Oxaprozin potassium is an orally active and potent inhibitor of COX, with IC 50 values of 2.2 μM and 36 μM for human platelet COX-1 and for IL-1-stimulated human synovial cell COX-2, respectively. Oxaprozin potassium in...
T68321 AS1940477
AS1940477 is p38 MAPK inhibitor. AS1940477 inhibited the enzymatic activity of recombinant p38α and β isoforms but showed no effect against other 100 protein kinases including p38γ and δ isoforms. In human peripheral blo...
T80242 TNO211 MMP
TNO211 is a bioactive peptide that functions as a highly soluble fluorogenic substrate for select Matrix Metalloproteinases (MMPs)—specifically MMP-2, 8, 12, 13, and 14. Incorporating a cleavable Gly-Leu bond and an EDAN...
カタログ番号 製品名 別名 ターゲット
TN4893 Rapanone 2,5-Dihydroxy-3-tridecyl-[1,4]benzoquinone,2,5-Dihydroxy-3-tridecylcyclohexa-2,5-diene-1,4-dione Apoptosis , Phospholipase , Antibacterial , Parasite
Rapanone (2,5-Dihydroxy-3-tridecyl-[1,4]benzoquinone) is a natural benzoquinone that is a potent and selective inhibitor of human synovial PLA2.
T3762 Hyaluronic acid Hyaluronate,hyaluronan Others , Endogenous Metabolite
Hyaluronic acid (hyaluronan) is a glucosaminoglycan consisting of D-glucuronic acid and N-acetyl-D-glucosamine disaccharide units that is a component of connective tissue, skin, vitreous humour, umbilical cord, synovial ...
T21893 Luffariellolide
Luffariellolide is an inhibitor of human synovial fluid phospholipase A2 ( HSF-PLA2 ) (IC 50 =5 μM). PMA-induced ear edema was effectively inhibited by luffariellolide (ED 50 =50 μg/ear) [1].
TN4505 Masticadienolic acid Others
Masticadienolic acid is a specific competitive inhibitor of secreted phospholipase A2, it not only protects the active site histidine from alkylation but also inhibits the action of secreted from pancreas, synovial fluid...

Recombinant Proteins

カタログ番号 製品名 Species Expression System
TMPY-04912 PLA2G2A Protein, Mouse, Recombinant (His) Mouse P. pastoris (Yeast)
PLA2G2A Protein, Mouse, Recombinant (His) is expressed in yeast with His tag. The predicted molecular weight is 15.3 kDa and the accession number is P31482.
TMPY-01705 PLA2G2A Protein, Human, Recombinant (His) Human HEK293 Cells
PLA2G2A Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 15.4 kDa and the accession number is A0A024RA96.
TMPJ-01172 IL-17 Protein, Mouse, Recombinant (His) Mouse HEK293 Cells
Interleukin-17 is a potent pro-inflammatory cytokine produced by activated memory T cells. There are at least six members of the IL-17 family in humans and in mice. Mature mouse IL-17A shares 61% and 89% amino acid seque...
TMPY-00021 PADI4 Protein, Human, Recombinant (His) Human Baculovirus Insect Cells
Protein-arginine deiminase type-4, also known as HL-6 PAD, Peptidylarginine deiminase IV, Protein-arginine deiminase type I V and PADI4, is a cytoplasm and nucleus protein that belongs to the protein arginine deiminase f...
TMPH-01973 Proteoglycan 4 Protein, Human, Recombinant (His) Human P. pastoris (Yeast)
Plays a role in boundary lubrication within articulating joints. Prevents protein deposition onto cartilage from synovial fluid by controlling adhesion-dependent synovial growth and inhibiting the adhesion of synovial ce...
TMPH-02856 SAAL1 Protein, Mouse, Recombinant (His & Myc) Mouse E. coli
Plays a role in promoting the proliferation of synovial fibroblasts in response to proinflammatory stimuli.
TMPK-00019 B2M/beta 2-Microglobulin Protein, Human, Recombinant (hFc) Human HEK293 Cells
To assess whether beta-2 microglobulin (B2M) has effects on articular chondrocytes that would implicate B2M involvement in osteoarthritis (OA) pathogenesis.The average B2M level in OA synovial fluid is significantly high...
TMPY-01933 CHI3L2 Protein, Human, Recombinant (His) Human HEK293 Cells
Chondrocyte protein 39 (YKL-39), also known as Chitinase 3-like 2 (CHI3L2), is a secretory protein of articular chondrocytes belonging to the glycosyl hydrolase 18 family. Its highest expression is in chondrocytes, follo...
TMPK-01057 CLEC9A Protein, Human, Recombinant (hFc) Human HEK293 Cells
CLEC9A expression was significantly higher in psoriatic skin compared with healthy donor. In psoriatic skin and PsA ST, CLEC9A() cells were in close proximity to TUNEL() cells. SF CLEC9A levels were significantly lower c...
TMPH-02438 IL-1 alpha/IL1A Protein, Rhesus macaque, Recombinant (His & SUMO) Rhesus E. coli
Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammat...
TMPK-01117 OSCAR Protein, Mouse, Recombinant (hFc) Mouse HEK293 Cells
Osteoclast-associated receptor (OSCAR) is a co-stimulatory receptor in osteoclastogenesis. Synovial tissues from active rheumatoid arthritis (RA) patients express higher levels of OSCAR compared with osteoarthritic and n...
TMPK-01092 OSCAR Protein, Human, Recombinant (hFc) Human HEK293 Cells
Osteoclast-associated receptor (OSCAR) is a co-stimulatory receptor in osteoclastogenesis. Synovial tissues from active rheumatoid arthritis (RA) patients express higher levels of OSCAR compared with osteoarthritic and n...
TMPJ-01392 IL-1 beta/IL-1F2 Protein, Cavia porcellus, Recombinant (His) Cavia porcellus E. coli
Interleukin-1 beta (IL1B) belongs to the IL-1 family. Interleukin 1 (IL-1) is a family of polypeptide cytokines consisting of two agonists, IL-1 alpha (IL-1F1) and IL-1 beta (IL-1F2) encoded by two distinct genes and per...
TMPJ-01444 IL-17A Protein, Cynomolgus, Recombinant (His) Cynomolgus HEK293 Cells
Interleukin-17 is a potent pro-inflammatory cytokine produced by activated memory T cells. There are at least six members of the IL-17 family in humans and in mice. As IL-17 shares properties with IL-1 and TNF-alpha, it ...
TMPJ-01234 IL-36 gamma Protein, Mouse, Recombinant Mouse E. coli
Interleukin-36 gamma (IL-36γ) is a member of the interleukin 1 cytokine family that includes three closely related genes, IL-36α, β, and γ, formerly known as IL-1F6, F8, and F9 respectively. IL-36α has been detected in b...
TMPY-00564 MCP-4 Protein, Human, Recombinant (His) Human P. pastoris (Yeast)
Monocyte Chemoattractant Proteins 4 (MCP-4/CCL13) is a member of a distinct, structurally-related subclass of CC chemokines mainly involved in recruitment of eosinphils to inflammatory sites. CCL13/MCP-4, is a CC family ...
TMPY-03397 TPPP3 Protein, Human, Recombinant (His) Human E. coli
TPPP3, a member of the Tubulin polymerization-promoting protein family, is an intrinsically unstructured protein that induces tubulin polymerization. TPPP3 is a marker in the developing musculoskeletal system. In tendons...
PLA2G2A Protein, Mouse, Recombinant (His)
TMPY-04912
Species: Mouse
Expression System: P. pastoris (Yeast)
PLA2G2A Protein, Human, Recombinant (His)
TMPY-01705
Species: Human
Expression System: HEK293 Cells
IL-17 Protein, Mouse, Recombinant (His)
TMPJ-01172
Species: Mouse
Expression System: HEK293 Cells
PADI4 Protein, Human, Recombinant (His)
TMPY-00021
Species: Human
Expression System: Baculovirus Insect Cells
Proteoglycan 4 Protein, Human, Recombinant (His)
TMPH-01973
Species: Human
Expression System: P. pastoris (Yeast)
SAAL1 Protein, Mouse, Recombinant (His & Myc)
TMPH-02856
Species: Mouse
Expression System: E. coli
B2M/beta 2-Microglobulin Protein, Human, Recombinant (hFc)
TMPK-00019
Species: Human
Expression System: HEK293 Cells
CHI3L2 Protein, Human, Recombinant (His)
TMPY-01933
Species: Human
Expression System: HEK293 Cells
CLEC9A Protein, Human, Recombinant (hFc)
TMPK-01057
Species: Human
Expression System: HEK293 Cells
IL-1 alpha/IL1A Protein, Rhesus macaque, Recombinant (His & SUMO)
TMPH-02438
Species: Rhesus
Expression System: E. coli
OSCAR Protein, Mouse, Recombinant (hFc)
TMPK-01117
Species: Mouse
Expression System: HEK293 Cells
OSCAR Protein, Human, Recombinant (hFc)
TMPK-01092
Species: Human
Expression System: HEK293 Cells
IL-1 beta/IL-1F2 Protein, Cavia porcellus, Recombinant (His)
TMPJ-01392
Species: Cavia porcellus
Expression System: E. coli
IL-17A Protein, Cynomolgus, Recombinant (His)
TMPJ-01444
Species: Cynomolgus
Expression System: HEK293 Cells
IL-36 gamma Protein, Mouse, Recombinant
TMPJ-01234
Species: Mouse
Expression System: E. coli
MCP-4 Protein, Human, Recombinant (His)
TMPY-00564
Species: Human
Expression System: P. pastoris (Yeast)
TPPP3 Protein, Human, Recombinant (His)
TMPY-03397
Species: Human
Expression System: E. coli