Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BIX02189 is a potent and selective inhibitor of MEK5 and ERK5(IC50 : 1.5 nM and 59 nM).
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 8,000 | |||
5 mg | 在庫あり | ¥ 18,000 | |||
10 mg | 在庫あり | ¥ 27,000 | |||
25 mg | 在庫あり | ¥ 49,000 | |||
50 mg | 在庫あり | ¥ 85,000 | |||
100 mg | 在庫あり | ¥ 126,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 20,500 |
説明 | BIX02189 is a potent and selective inhibitor of MEK5 and ERK5(IC50 : 1.5 nM and 59 nM). |
ターゲット&IC50 | RPS6KA6/RSK4:990 nM, ERK5:59 nM, RPS6KA3/RSK2:2.1 μM, c-Kit:1.1 μM, Abl-1:2.4 μM, FGFR1:1 μM, CSF1R (FMS):46 nM, JAK3:440 nM, MEK5:1.5 nM, TGFβRI:580 nM, Lck:250 nM |
In vitro | BIX02189, which inhibited catalytic function of purified, MEK5 enzyme.?The MEK5 inhibitors blocked phosphorylation of ERK5, without affecting phosphorylation of ERK1/2 in sorbitol-stimulated HeLa cells.?The compounds also inhibited transcriptional activation of MEF2C, a downstream substrate of the MEK5/ERK5 signaling cascade, in a cellular trans-reporter assay system[1]. |
別名 | BIX 02189 |
分子量 | 440.54 |
分子式 | C27H28N4O2 |
CAS No. | 1265916-41-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 49.4 mg/mL (112.14 mM)
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
BIX02189 1265916-41-3 MAPK ERK MEK Mitogen-activated protein kinase kinase inhibit MAP2K MAPKK BIX 02189 BIX-02189 Extracellular signal regulated kinases Inhibitor inhibitor