Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PF-CBP1 hydrochloride (PF-CBP1 HCl) is a highly selective inhibitor of the bromodomain of CREB-binding protein(CREBBP).It inhibits CREBBP and p300 bromodomains with IC50 of 125 and 363 nM respectively.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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5 mg | 在庫あり | ¥ 9,000 | |||
10 mg | 在庫あり | ¥ 13,500 | |||
25 mg | 在庫あり | ¥ 28,000 | |||
50 mg | 在庫あり | ¥ 45,500 | |||
100 mg | 在庫あり | ¥ 85,000 | |||
200 mg | 在庫あり | ¥ 110,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 12,500 |
説明 | PF-CBP1 hydrochloride (PF-CBP1 HCl) is a highly selective inhibitor of the bromodomain of CREB-binding protein(CREBBP).It inhibits CREBBP and p300 bromodomains with IC50 of 125 and 363 nM respectively. |
ターゲット&IC50 | CREBBP:125nM, p300/CBP:363nM |
In vitro | PF-CBP1 modulates key inflammatory genes in primary macrophages. PF-CBP1 down regulates RGS4 in neurons, a target linked to Parkinson's disease.It is 139-fold selective over BRD4 in the biochemical assays and >105-fold selective by ITC.PF-CBP1 is also a potent inhibitor of EP300 and possesses no cytotoxicity in macrophages, and hepatotoxicity in cell-based models as long as the concentration is not very high[1]. |
別名 | PF-CBP1 HCl |
分子量 | 525.08 |
分子式 | C29H37ClN4O3 |
CAS No. | 2070014-93-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45 mg/mL (85.7 mM)
You can also refer to dose conversion for different animals. 詳細
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PF-CBP1 hydrochloride 2070014-93-4 Chromatin/Epigenetic Epigenetic Reader Domain Histone Acetyltransferase parkinson's disease HATs cortical inflammatory HAT PF CBP1 hydrochloride PF-CBP1 Hydrochloride inhibit RGS4 epilepsy PF-CBP1 PFCBP1 hydrochloride Inhibitor PF-CBP1 HCl neurological disorder PF-CBP-1 hydrochloride neuron inhibitor