| T16266 |
NAMI-A
|
201653-76-1
|
98%
|
|
|
NAMI-A is a ruthenium-based compound with selective activity against tumor metastasis.NAMI-A inhibits cancer cell adhesion and migration.
|
| T9973 |
FAK-IN-7
|
19948-85-7
|
98%
|
|
|
FAK-IN-7 has potential antiproliferative activity and is a FAK inhibitor.
|
| T9545 |
Compound 1T-0219 (SC)
|
383147-92-0
|
98%
|
|
|
Compound 1T-0219 (SC) is a blocker of AKT1-FAK interaction reducing the stimulation of FAK phosphorylation in response to extracellular pressure in human SW620 c...
|
| T8544 |
Masitinib mesylate
|
1048007-93-7
|
98%
|
|
|
Masitinib mesylate (AB-1010 mesylate) is a selective and orally bioavailable c-Kit inhibitor (IC50 of 200 nM,540/800 nM,510 nM for human recombinant c-Kit;PDGFRα...
|
| T2281 |
GSK2256098
|
1224887-10-8
|
|
|
|
GSK2256098 (GTPL7939) is a small molecule FAK kinase inhibitor.
|
| T6997 |
SU6656
|
330161-87-0
|
97%
|
|
|
SU 6656 is a selective inhibitor of Src family kinases, with IC50 of 280 nM, 20 nM, 130 nM, and 170 nM for Src, Yes, Lyn, and Fyn, respectively.
|
| T24730 |
Roslin 2 bromide
|
29574-21-8
|
97.07%
|
|
|
Roslin 2 bromide (Benzylhexamethylenetetramine bromide) is a p53 reactivator that disrupts the binding of FAK and p5. Roslin 2 bromide exhibits anticancer effect...
|
| T13564 |
AZ7550
|
1421373-99-0
|
97.07%
|
|
|
AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).
|
| T5480 |
BI-4464
|
1227948-02-8
|
97.43%
|
|
|
BI-4464 is a highly selective ATP competitive inhibitor of PTK2/FAK, with an IC50 of 17 nM. A PTK2 ligand for PROTAC
|
| T2465 |
PF-562271
|
717907-75-0
|
97.65%
|
|
|
PF-562271 is an effective ATP-competitive, reversible inhibitor of FAK(IC50=1.5 nM) and Pyk2 kinase(IC50=13 nM).
|
| T24642 |
YH-306
|
1373764-75-0
|
97.87%
|
|
|
YH-306 (TRV055 acetate ) is a modulator of the FAK signaling pathway that acts by suppressing colorectal tumor growth and metastasis.
|
| T7119 |
Y15
|
4506-66-5
|
98%
|
|
|
Y15 (1,2,4,5-Benzenetetramine tetrahydrochlor) is a potent and specificsmall-molecule FAK scaffolding inhibitor that inhibits its autophosphorylation activity, b...
|
| T1918 |
NVP-TAE 226
|
761437-28-9
|
98.07%
|
|
|
NVP-TAE 226 (TAE226) is an effective FAK inhibitor (IC50: 5.5 nM) and most effective to Pyk2(IC50: 3.5 nM); 10- to 100-fold less effective against IGF-1R, InsR, ...
|
| T2314 |
PF-431396
|
717906-29-1
|
98.48%
|
|
|
PF-431396 is a dual PYK2/FAK inhibitor (IC50: 11/2 nM).
|
| T21768 |
PF-562271 hydrochloride
|
939791-41-0
|
98.52%
|
|
|
PF-562271 hydrochloride (PF-562271 HCl) is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM in cell-free assays, ~10-fold less potent f...
|
| T10285 |
ALK inhibitor 1
|
761436-81-1
|
98.55%
|
|
|
ALK inhibitor 1 is a selective ALK kinase inhibitor.
|
| T2001 |
PF-573228
|
869288-64-2
|
98.86%
|
|
|
PF-573228 is an ATP-competitive FAK inhibitor. In a cell-free assay, the IC50 of FAK is 4 nM.
|
| T5S0761 |
Nitidine chloride
|
13063-04-2
|
98.91%
|
|
|
1. Nitidine chloride has inhibitory effects on various tumors, such as renal cancer , breast cancer. 2. Nitidine chloride inhibits the proliferation of SMMC-7721...
|
| T3041 |
ALK inhibitor 2
|
761438-38-4
|
99%
|
|
|
ALK inhibitor 2 is a new-type and selective inhibitor for the ALK kinase.
|
| T2655 |
CEP-37440
|
1391712-60-9
|
99.01%
|
|
|
CEP-37440 is an effective and specific Dual FAK/ALK inhibitor with IC50s of 120 nM(ALK cellular in 75% human plasma) and 2.3 nM (FAK).
|
