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FAK

Focal adhesion kinase (FAK), a non-receptor tyrosine kinase, is the first intracellular step in the signal transduction cascade initiated by the attachment of an integrin to the extracellular matrix at points known as focal adhesions. FAK has a key role in cellular migration and motility.
Cat. No. 製品名 CAS No. Purity Chemical Structure
T16266 NAMI-A 201653-76-1 98%
NAMI-A is a ruthenium-based compound with selective activity against tumor metastasis.NAMI-A inhibits cancer cell adhesion and migration.
T9973 FAK-IN-7 19948-85-7 98%
FAK-IN-7 has potential antiproliferative activity and is a FAK inhibitor.
T9545 Compound 1T-0219 (SC) 383147-92-0 98%
Compound 1T-0219 (SC) is a blocker of AKT1-FAK interaction reducing the stimulation of FAK phosphorylation in response to extracellular pressure in human SW620 c...
T9576 AMP-945 1393653-34-3
AMP-945 is a proprietary focal adhesion kinase (FAK) inhibitor.
T2281 GSK2256098 1224887-10-8
GSK2256098 (GTPL7939) is a small molecule FAK kinase inhibitor.
T6997 SU6656 330161-87-0 97%
SU 6656 is a selective inhibitor of Src family kinases, with IC50 of 280 nM, 20 nM, 130 nM, and 170 nM for Src, Yes, Lyn, and Fyn, respectively.
T24730 Roslin 2 bromide 29574-21-8 97.07%
Roslin 2 bromide (Benzylhexamethylenetetramine bromide) is a p53 reactivator that disrupts the binding of FAK and p5. Roslin 2 bromide exhibits anticancer effect...
T13564 AZ7550 1421373-99-0 97.07%
AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).
T5480 BI-4464 1227948-02-8 97.43%
BI-4464 is a highly selective ATP competitive inhibitor of PTK2/FAK, with an IC50 of 17 nM. A PTK2 ligand for PROTAC
T2465 PF-562271 717907-75-0 97.65%
PF-562271 is an effective ATP-competitive, reversible inhibitor of FAK(IC50=1.5 nM) and Pyk2 kinase(IC50=13 nM).
T24642 YH-306 1373764-75-0 97.87%
YH-306 (TRV055 acetate ) is a modulator of the FAK signaling pathway that acts by suppressing colorectal tumor growth and metastasis.
T7119 Y15 4506-66-5 98%
Y15 (1,2,4,5-Benzenetetramine tetrahydrochlor) is a potent and specificsmall-molecule FAK scaffolding inhibitor that inhibits its autophosphorylation activity, b...
T1918 NVP-TAE 226 761437-28-9 98.07%
NVP-TAE 226 (TAE226) is an effective FAK inhibitor (IC50: 5.5 nM) and most effective to Pyk2(IC50: 3.5 nM); 10- to 100-fold less effective against IGF-1R, InsR, ...
T2314 PF-431396 717906-29-1 98.48%
PF-431396 is a dual PYK2/FAK inhibitor (IC50: 11/2 nM).
T21768 PF-562271 hydrochloride 939791-41-0 98.52%
PF-562271 hydrochloride (PF-562271 HCl) is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM in cell-free assays, ~10-fold less potent f...
T10285 ALK inhibitor 1 761436-81-1 98.55%
ALK inhibitor 1 is a selective ALK kinase inhibitor.
T2001 PF-573228 869288-64-2 98.86%
PF-573228 is an ATP-competitive FAK inhibitor. In a cell-free assay, the IC50 of FAK is 4 nM.
T5S0761 Nitidine chloride 13063-04-2 98.91%
1. Nitidine chloride has inhibitory effects on various tumors, such as renal cancer , breast cancer. 2. Nitidine chloride inhibits the proliferation of SMMC-7721...
T3041 ALK inhibitor 2 761438-38-4 99%
ALK inhibitor 2 is a new-type and selective inhibitor for the ALK kinase.
T2655 CEP-37440 1391712-60-9 99.01%
CEP-37440 is an effective and specific Dual FAK/ALK inhibitor with IC50s of 120 nM(ALK cellular in 75% human plasma) and 2.3 nM (FAK).
NAMI-A
T16266
NAMI-A is a ruthenium-based compound with selective activity against tumor metastasis.NAMI-A inhibits cancer cell adhesion and migration.
FAK-IN-7
T9973
FAK-IN-7 has potential antiproliferative activity and is a FAK inhibitor.
Compound 1T-0219 (SC)
T9545
Compound 1T-0219 (SC) is a blocker of AKT1-FAK interaction reducing the stimulation of FAK phosphorylation in response to extracellular pressure in human SW620 c...
AMP-945
T9576
AMP-945 is a proprietary focal adhesion kinase (FAK) inhibitor.
GSK2256098
T2281
GSK2256098 (GTPL7939) is a small molecule FAK kinase inhibitor.
SU6656
T6997
SU 6656 is a selective inhibitor of Src family kinases, with IC50 of 280 nM, 20 nM, 130 nM, and 170 nM for Src, Yes, Lyn, and Fyn, respectively.
Roslin 2 bromide
T24730
Roslin 2 bromide (Benzylhexamethylenetetramine bromide) is a p53 reactivator that disrupts the binding of FAK and p5. Roslin 2 bromide exhibits anticancer effect...
AZ7550
T13564
AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).
BI-4464
T5480
BI-4464 is a highly selective ATP competitive inhibitor of PTK2/FAK, with an IC50 of 17 nM. A PTK2 ligand for PROTAC
PF-562271
T2465
PF-562271 is an effective ATP-competitive, reversible inhibitor of FAK(IC50=1.5 nM) and Pyk2 kinase(IC50=13 nM).
YH-306
T24642
YH-306 (TRV055 acetate ) is a modulator of the FAK signaling pathway that acts by suppressing colorectal tumor growth and metastasis.
Y15
T7119
Y15 (1,2,4,5-Benzenetetramine tetrahydrochlor) is a potent and specificsmall-molecule FAK scaffolding inhibitor that inhibits its autophosphorylation activity, b...
NVP-TAE 226
T1918
NVP-TAE 226 (TAE226) is an effective FAK inhibitor (IC50: 5.5 nM) and most effective to Pyk2(IC50: 3.5 nM); 10- to 100-fold less effective against IGF-1R, InsR, ...
PF-431396
T2314
PF-431396 is a dual PYK2/FAK inhibitor (IC50: 11/2 nM).
PF-562271 hydrochloride
T21768
PF-562271 hydrochloride (PF-562271 HCl) is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM in cell-free assays, ~10-fold less potent f...
ALK inhibitor 1
T10285
ALK inhibitor 1 is a selective ALK kinase inhibitor.
PF-573228
T2001
PF-573228 is an ATP-competitive FAK inhibitor. In a cell-free assay, the IC50 of FAK is 4 nM.
Nitidine chloride
T5S0761
1. Nitidine chloride has inhibitory effects on various tumors, such as renal cancer , breast cancer. 2. Nitidine chloride inhibits the proliferation of SMMC-7721...
ALK inhibitor 2
T3041
ALK inhibitor 2 is a new-type and selective inhibitor for the ALK kinase.
CEP-37440
T2655
CEP-37440 is an effective and specific Dual FAK/ALK inhibitor with IC50s of 120 nM(ALK cellular in 75% human plasma) and 2.3 nM (FAK).
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