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FAK

Focal adhesion kinase (FAK), a non-receptor tyrosine kinase, is the first intracellular step in the signal transduction cascade initiated by the attachment of an integrin to the extracellular matrix at points known as focal adhesions. FAK has a key role in cellular migration and motility.
Cat. No. 製品名 CAS No. Purity Chemical Structure
T16266 NAMI-A 201653-76-1 98%
NAMI-A is a ruthenium-based compound with selective activity against tumor metastasis.NAMI-A inhibits cancer cell adhesion and migration.
T9973 FAK-IN-7 19948-85-7 98%
FAK-IN-7 has potential antiproliferative activity and is a FAK inhibitor.
T9545 Compound 1T-0219 (SC) 383147-92-0 98%
Compound 1T-0219 (SC) is a blocker of AKT1-FAK interaction reducing the stimulation of FAK phosphorylation in response to extracellular pressure in human SW620 c...
T8544 Masitinib mesylate 1048007-93-7 98%
Masitinib mesylate (AB-1010 mesylate) is a selective and orally bioavailable c-Kit inhibitor (IC50 of 200 nM,540/800 nM,510 nM for human recombinant c-Kit;PDGFRα...
T77718 FAK-IN-10 491839-65-7 98%
FAK-IN-10 is an inhibitor of FAK (IC50:76.3 μM).FAK-IN-10 z MCF-7 and A431 cell lines showed antitumor activity with IC50 of 4.23 and 0.78 μM, respectively.
T2314 PF-431396 717906-29-1 98%
PF-431396 is a dual PYK2/FAK inhibitor (IC50: 11/2 nM).
T5480 BI-4464 1227948-02-8
BI-4464 is a highly selective ATP competitive inhibitor of PTK2/FAK, with an IC50 of 17 nM. A PTK2 ligand for PROTAC
T2281 GSK2256098 1224887-10-8
GSK2256098 (GTPL7939) is a small molecule FAK kinase inhibitor.
T1996 Defactinib 1073154-85-4
Defactinib (VS-6063) is an orally bioavailable, small-molecule focal adhesion kinase (FAK) inhibitor with potential antiangiogenic and antineoplastic activities....
T5S0761 Nitidine chloride 13063-04-2 96.59%
1. Nitidine chloride has inhibitory effects on various tumors, such as renal cancer , breast cancer. 2. Nitidine chloride inhibits the proliferation of SMMC-7721...
T6997 SU6656 330161-87-0 97%
SU 6656 is a selective inhibitor of Src family kinases, with IC50 of 280 nM, 20 nM, 130 nM, and 170 nM for Src, Yes, Lyn, and Fyn, respectively.
T24730 Roslin 2 bromide 29574-21-8 97.07%
Roslin 2 bromide (Benzylhexamethylenetetramine bromide) is a p53 reactivator that disrupts the binding of FAK and p5. Roslin 2 bromide exhibits anticancer effect...
T13564 AZ7550 1421373-99-0 97.07%
AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).
T2465 PF-562271 717907-75-0 97.65%
PF-562271 is an effective ATP-competitive, reversible inhibitor of FAK(IC50=1.5 nM) and Pyk2 kinase(IC50=13 nM).
T24642 YH-306 1373764-75-0 97.87%
YH-306 (TRV055 acetate ) is a modulator of the FAK signaling pathway that acts by suppressing colorectal tumor growth and metastasis.
T7119 Y15 4506-66-5 98%
Y15 (1,2,4,5-Benzenetetramine tetrahydrochlor) is a potent and specificsmall-molecule FAK scaffolding inhibitor that inhibits its autophosphorylation activity, b...
T1918 NVP-TAE 226 761437-28-9 98.07%
NVP-TAE 226 (TAE226) is an effective FAK inhibitor (IC50: 5.5 nM) and most effective to Pyk2(IC50: 3.5 nM); 10- to 100-fold less effective against IGF-1R, InsR, ...
T21768 PF-562271 hydrochloride 939791-41-0 98.52%
PF-562271 hydrochloride (PF-562271 HCl) is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM in cell-free assays, ~10-fold less potent f...
T10285 ALK inhibitor 1 761436-81-1 98.55%
ALK inhibitor 1 is a selective ALK kinase inhibitor.
T3122 Fangchinoline 436-77-1 98.81%
Fangchinoline (Tetrandrine B) is extracted from Stephania tetrandra S. Moore.
NAMI-A
T16266
NAMI-A is a ruthenium-based compound with selective activity against tumor metastasis.NAMI-A inhibits cancer cell adhesion and migration.
FAK-IN-7
T9973
FAK-IN-7 has potential antiproliferative activity and is a FAK inhibitor.
Compound 1T-0219 (SC)
T9545
Compound 1T-0219 (SC) is a blocker of AKT1-FAK interaction reducing the stimulation of FAK phosphorylation in response to extracellular pressure in human SW620 c...
Masitinib mesylate
T8544
Masitinib mesylate (AB-1010 mesylate) is a selective and orally bioavailable c-Kit inhibitor (IC50 of 200 nM,540/800 nM,510 nM for human recombinant c-Kit;PDGFRα...
FAK-IN-10
T77718
FAK-IN-10 is an inhibitor of FAK (IC50:76.3 μM).FAK-IN-10 z MCF-7 and A431 cell lines showed antitumor activity with IC50 of 4.23 and 0.78 μM, respectively.
PF-431396
T2314
PF-431396 is a dual PYK2/FAK inhibitor (IC50: 11/2 nM).
BI-4464
T5480
BI-4464 is a highly selective ATP competitive inhibitor of PTK2/FAK, with an IC50 of 17 nM. A PTK2 ligand for PROTAC
GSK2256098
T2281
GSK2256098 (GTPL7939) is a small molecule FAK kinase inhibitor.
Defactinib
T1996
Defactinib (VS-6063) is an orally bioavailable, small-molecule focal adhesion kinase (FAK) inhibitor with potential antiangiogenic and antineoplastic activities....
Nitidine chloride
T5S0761
1. Nitidine chloride has inhibitory effects on various tumors, such as renal cancer , breast cancer. 2. Nitidine chloride inhibits the proliferation of SMMC-7721...
SU6656
T6997
SU 6656 is a selective inhibitor of Src family kinases, with IC50 of 280 nM, 20 nM, 130 nM, and 170 nM for Src, Yes, Lyn, and Fyn, respectively.
Roslin 2 bromide
T24730
Roslin 2 bromide (Benzylhexamethylenetetramine bromide) is a p53 reactivator that disrupts the binding of FAK and p5. Roslin 2 bromide exhibits anticancer effect...
AZ7550
T13564
AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).
PF-562271
T2465
PF-562271 is an effective ATP-competitive, reversible inhibitor of FAK(IC50=1.5 nM) and Pyk2 kinase(IC50=13 nM).
YH-306
T24642
YH-306 (TRV055 acetate ) is a modulator of the FAK signaling pathway that acts by suppressing colorectal tumor growth and metastasis.
Y15
T7119
Y15 (1,2,4,5-Benzenetetramine tetrahydrochlor) is a potent and specificsmall-molecule FAK scaffolding inhibitor that inhibits its autophosphorylation activity, b...
NVP-TAE 226
T1918
NVP-TAE 226 (TAE226) is an effective FAK inhibitor (IC50: 5.5 nM) and most effective to Pyk2(IC50: 3.5 nM); 10- to 100-fold less effective against IGF-1R, InsR, ...
PF-562271 hydrochloride
T21768
PF-562271 hydrochloride (PF-562271 HCl) is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM in cell-free assays, ~10-fold less potent f...
ALK inhibitor 1
T10285
ALK inhibitor 1 is a selective ALK kinase inhibitor.
Fangchinoline
T3122
Fangchinoline (Tetrandrine B) is extracted from Stephania tetrandra S. Moore.
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