ペプチド
抗体
色素試薬
PROTAC
バーチャルスクリーニング
TargetMolキット
Cell Counting Kit-8 (CCK-8)
Inhibitor Cocktails
天然化合物
フェノール類
アルカロイド類
フラボノイド類
阻害剤
血管新生
アポトーシス
オートファジー
細胞周期・チェックポイント
クロマチン・エピジェネティック
細胞骨格シグナル
DNA損傷・DNA修復
内分泌・ホルモン
GPCR/Gタンパク質
免疫・炎症
JAK・STATシグナル
| Cat. No. | 製品名 | CAS No. | Purity | Chemical Structure |
|---|---|---|---|---|
| T9698 | UC2288 | 1394011-91-6 | 98% |
|
| UC2288 is a relatively selective p21 attenuator which is synthesized based Sorafenib. UC2288 attenuates p21 protein levels with minimal effect on p21 protein sta... | ||||
| T6965 | RG7112 | 939981-39-2 | 98% |
|
| RG7112 (RO5045337) is an orally bioavailable and selective p53-MDM2 inhibitor. | ||||
| T28078 | MMRi64 | 430458-66-5 | 98% |
|
| MMRi64 is a specific inhibitor of Mdm2-MdmX E3 ligase activity.MMRi64 potently induces p53 accumulation and apoptosis in the p53 pathway in leukemia/lymphoma cel... | ||||
| T11980 | MD-224 | 2136247-12-4 | 98% |
|
| MD-224 is a highly potent and efficacious MDM2 degrader based on the proteolysistargeting chimera (PROTAC) concept,and as a new class of anticancer agent. | ||||
| T21578 | NSC 66811 | 6964-62-1 | 98% |
|
| NSC 66811is a novel inhibitor of the murine double minute 2 (MDM2)-p53 interaction. It binds to MDM2 with a Ki of 120 nM and activates p53 in cancer cells with a... | ||||
| T3653 | MX69 | 1005264-47-0 | 98% |
|
| MX69 is the MDM2/XIAP inhibitor, blocking the MDM2 protein-XIAP RNA interaction, leading to MDM2 degradation. | ||||
| T1798 | RITA | 213261-59-7 | 98% |
|
| RITA(NSC 652287) induced cross-links of both DNA-DNA and DNA-protein with no detectable DNA single-strand breaks. RITA, like nutlin-3, can disrupt the p53/Mdm2 i... | ||||
| T28509 | RDR03871 | 286008-51-3 | 98% |
|
| RDR03871 is an MDM2 inhibitor. | ||||
| T6585 | SAR405838 | 1303607-60-4 | 98% |
|
| MI-773 (SAR405838) is an orally available MDM2 antagonist with Ki of 0.88 nM. Phase 1. | ||||
| T2243 | Serdemetan | 881202-45-5 | 98% |
|
| Serdemetan is an orally bioavailable HDM2 antagonist with potential antineoplastic activity. | ||||
| T16523L | PhiKan 083 | 880813-36-5 | 98% |
|
| PhiKan 083 is a carbazole derivative | ||||
| T72026 | P53-MDM2-IN-1 | 381717-91-5 | 98% |
|
| p53-MDM2-IN-1 (Example 30) is an inhibitor of p53-MDM2/X protein interaction with an K i value of 23.35 µM. p53-MDM2-IN-1 can be used for anti-tumor research . | ||||
| T2179 | Triptolide | 38748-32-2 | 98% |
|
| Triptolide is a diterpenes trioxide, immunosuppressive agent extracted from the Chinese herb Tripterygium wilfordii. | ||||
| T14303 | Alrizomadlin | 1818393-16-6 | 98% |
|
| Alrizomadlin is an orally active inhibitor of MDM2 with IC50 of 3.8 nM and Ki of 1 nM, respectively[1]. Alrizomadlin blocks the interaction of MDM2 and p53 and i... | ||||
| T6614 | Nutlin-3b | 675576-97-3 | 98% |
|
| Nutlin-3b is a p53/MDM2 antagonist or inhibitor (IC50: 13.6 μM), 150-fold less potent (+)-enantiomer of Nutlin-3 as in comparison with opposite (-)-enantiomer Nu... | ||||
| TQ0127 | Navtemadlin | 1352066-68-2 | 98% |
|
| AMG 232 is a potent, selective and orally available inhibitor of p53-MDM2 interaction (IC50: 0.6 nM). It binds to MDM2 with a Kd of 0.045 nM. | ||||
| T3517 | RO8994 | 1309684-94-3 | 98% |
|
| RO8994 is a highly effective and specific inhibitor of spiroindolinone small-molecule MDM2, with IC50 of 20 nM (MTT proliferation assays) and 5 nM (HTRF binding ... | ||||
| TQ0231 | NVP-CGM097 | 1313363-54-0 | 98% |
|
| NVP-CGM097 is an effective and specific MDM2 inhibitor (IC50: 1.7 nM for hMDM2). | ||||
| T6610 | NSC-207895 | 58131-57-0 | 98% |
|
| NSC 207895 suppresses MDMX with IC50 of 2.5 μM, leading to enhanced p53 stabilization/activation and DNA damage, and also regulates MDM2, an E3 ligase. | ||||
| T21773 | SP-141 | 1253491-42-7 | 98% |
|
| SP 141 is a MDM2 inhibitor.SP-141 promotes MDM2 auto-ubiquitination and degradation, with anticancer activity. | ||||
