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Sigma receptor

The sigma receptors σ1 and σ2 bind to ligands such as 4-PPBP (4-phenyl-1-(4-phenylbutyl) piperidine), SA 4503 (cutamesine), ditolylguanidine, dimethyltryptamine, and siramesine. They are named by pharmacological similarities, and are evolutionarily unrelated.
Cat. No. 製品名 CAS No. Purity Chemical Structure
T22904 L-745870 trihydrochloride 866021-03-6 98%
L-745870 trihydrochloride is a highly potent and selective D4 dopamine receptor antagonist.
T1885 Siramesine hydrochloride 224177-60-0 98%
Siramesine hydrochloride (Lu 28-179 hydrochloride) is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of Y cells and to exhibit ...
T77593 KSK67 2566715-93-1 98%
KSK67 is a selective dual antagonist of sigma-2 and histamine H3 receptors with inhibitory effects on H3 receptors, sigma-1, and sigma-2 receptors, with Ki value...
T13510 Sigma-LIGAND-1 139652-01-0 100%
Sigma-LIGAND-1 is a selective Sigma Receptor ligand with an IC50s of 16 nM, 19 nM at the DTG site and the PPP site, respectively. Sigma-LIGAND-1 has a Ki of 4000...
T12912 Sigma-1 receptor antagonist 3 1639220-17-9 100%
Sigma-1 receptor antagonist 3 is a potent and selective antagonist of Sigma-1 (σ1) receptor(Ki : 1.14 nM), has the potential for the neuropathic pain.
T1180 Blonanserin 132810-10-7 100%
Blonanserin (AD-5423) is an atypical antipsychotic approved in Japan in January, 2008. Relative to many other antipsychotics, blonanserin has an improved tolerab...
T15034 Roluperidone 359625-79-9 96.46%
Roluperidone (CYR-101) is a novel cyclic amide derivative. It has high equipotent affinities for 5-HT2A and σ2 receptors (Ki of 7.53 nM and 8.19 nM for 5-HT2A an...
T21788 BD 1008 dihydrobromide 138356-09-9 97.81%
BD 1008 dihydrobromide is a selective antagonist of the sigma 1 (σ1) receptor (Ki = 2 nM). BD 1008 dihydrobromide have high affinity for sigma1 receptors, modera...
T7488 BD1063 dhydrochloride 206996-13-6 98%
BD1063 dhydrochloride is a potent and selective sigma 1(σ1) receptor antagonist(Ki = 9 nM).
T5969 Ditolylguanidine 97-39-2 98%
Ditolylguanidine (Di-o-tolylguanidine) is an agonist of sigma receptor (σ1/σ2 receptor).
T22612 BMY-14802 hydrochloride 105565-55-7 98.64%
BMY-14802 hydrochloride (BMS 181100 hydrochloride) is a selective antagonist of σ receptor (IC50 = 112 nM) with antipsychotic effects. BMY-14802 hydrochloride is...
T3597 Cutamesine dihydrochloride 165377-44-6 98.83%
Cutamesine dihydrochloride (SA4503 dihydrochloride) is a selective σ1 receptor agonist (IC50: 17.4 nM). It shows selectivity for σ1 over σ2 receptors, and inhibi...
T20797 NE-100 hydrochloride  149409-57-4 98.85%
NE-100 hydrochloride (NE-100 HCl) is a potent and selective antagonist of σ1 (IC50 = 4.16 nM) with antipsychotic activity. NE100 HCl also suppresses ER stress-in...
T67739 BMY-14802 105565-56-8 98.93%
BMY-14802 (alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazine butanol) is a selective and orally active sigma-1 antagonist with an IC50 of 112 nM.
T15393 Glycerol phenylbutyrate 611168-24-2 99.00%
Glycerol phenylbutyrate (HPN-100) (GPB) is a new generation ammonia scavenger drug and it also is a sigma-2 (σ2) receptor ligand (pKi: 8.02).
T72059 S1R agonist 2 150085-21-5 99.04%
S1R agonist 2 is a selective S1R agonist with a Ki of 88 nM for S2R and 1.1 nM for S1R and is protective against ROS and NMDA-induced neurotoxicity.
T39211 PD 144418 oxalate 1794760-28-3 99.08%
PD 144418 oxalate is a highly potent and selective sigma 1 (σ1) receptor ligand, displaying a Ki value of 0.08 nM for σ1 and 1377 nM for σ2. It exhibits negligib...
T4596 4-IBP 155798-08-6 99.12%
4-IBP is a selective σ1 agonist with a high level of affinity for the σ1 receptor (Ki = 1.7 nM) and a moderate affinity for the σ2 receptor (Ki = 25.2 nM) .
T8834 EST64454 hydrochloride 1950569-11-5 99.15%
EST64454 hydrochloride (EST64454) is a highly soluble σ1 receptor antagonist (Ki : 22 nM),has the potential for Pain Management.
T1740 BD-1047 dihydrobromide 138356-21-5 99.39%
BD-1047 dihydrobromide (BD1047.2HBr) , a selective functional antagonist of sigma receptors, has antipsychotic activity in animal models predictive of efficacy i...
L-745870 trihydrochloride
T22904
L-745870 trihydrochloride is a highly potent and selective D4 dopamine receptor antagonist.
Siramesine hydrochloride
T1885
Siramesine hydrochloride (Lu 28-179 hydrochloride) is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of Y cells and to exhibit ...
KSK67
T77593
KSK67 is a selective dual antagonist of sigma-2 and histamine H3 receptors with inhibitory effects on H3 receptors, sigma-1, and sigma-2 receptors, with Ki value...
Sigma-LIGAND-1
T13510
Sigma-LIGAND-1 is a selective Sigma Receptor ligand with an IC50s of 16 nM, 19 nM at the DTG site and the PPP site, respectively. Sigma-LIGAND-1 has a Ki of 4000...
Sigma-1 receptor antagonist 3
T12912
Sigma-1 receptor antagonist 3 is a potent and selective antagonist of Sigma-1 (σ1) receptor(Ki : 1.14 nM), has the potential for the neuropathic pain.
Blonanserin
T1180
Blonanserin (AD-5423) is an atypical antipsychotic approved in Japan in January, 2008. Relative to many other antipsychotics, blonanserin has an improved tolerab...
Roluperidone
T15034
Roluperidone (CYR-101) is a novel cyclic amide derivative. It has high equipotent affinities for 5-HT2A and σ2 receptors (Ki of 7.53 nM and 8.19 nM for 5-HT2A an...
BD 1008 dihydrobromide
T21788
BD 1008 dihydrobromide is a selective antagonist of the sigma 1 (σ1) receptor (Ki = 2 nM). BD 1008 dihydrobromide have high affinity for sigma1 receptors, modera...
BD1063 dhydrochloride
T7488
BD1063 dhydrochloride is a potent and selective sigma 1(σ1) receptor antagonist(Ki = 9 nM).
Ditolylguanidine
T5969
Ditolylguanidine (Di-o-tolylguanidine) is an agonist of sigma receptor (σ1/σ2 receptor).
BMY-14802 hydrochloride
T22612
BMY-14802 hydrochloride (BMS 181100 hydrochloride) is a selective antagonist of σ receptor (IC50 = 112 nM) with antipsychotic effects. BMY-14802 hydrochloride is...
Cutamesine dihydrochloride
T3597
Cutamesine dihydrochloride (SA4503 dihydrochloride) is a selective σ1 receptor agonist (IC50: 17.4 nM). It shows selectivity for σ1 over σ2 receptors, and inhibi...
NE-100 hydrochloride 
T20797
NE-100 hydrochloride (NE-100 HCl) is a potent and selective antagonist of σ1 (IC50 = 4.16 nM) with antipsychotic activity. NE100 HCl also suppresses ER stress-in...
BMY-14802
T67739
BMY-14802 (alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazine butanol) is a selective and orally active sigma-1 antagonist with an IC50 of 112 nM.
Glycerol phenylbutyrate
T15393
Glycerol phenylbutyrate (HPN-100) (GPB) is a new generation ammonia scavenger drug and it also is a sigma-2 (σ2) receptor ligand (pKi: 8.02).
S1R agonist 2
T72059
S1R agonist 2 is a selective S1R agonist with a Ki of 88 nM for S2R and 1.1 nM for S1R and is protective against ROS and NMDA-induced neurotoxicity.
PD 144418 oxalate
T39211
PD 144418 oxalate is a highly potent and selective sigma 1 (σ1) receptor ligand, displaying a Ki value of 0.08 nM for σ1 and 1377 nM for σ2. It exhibits negligib...
4-IBP
T4596
4-IBP is a selective σ1 agonist with a high level of affinity for the σ1 receptor (Ki = 1.7 nM) and a moderate affinity for the σ2 receptor (Ki = 25.2 nM) .
EST64454 hydrochloride
T8834
EST64454 hydrochloride (EST64454) is a highly soluble σ1 receptor antagonist (Ki : 22 nM),has the potential for Pain Management.
BD-1047 dihydrobromide
T1740
BD-1047 dihydrobromide (BD1047.2HBr) , a selective functional antagonist of sigma receptors, has antipsychotic activity in animal models predictive of efficacy i...
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