Molecular Glues

Molecular glue refers to a class of chemical compounds or molecules that play a crucial role in binding and stabilizing protein-protein interactions in biological systems. These molecules act as "glue" by enhancing the affinity between proteins, ultimately influencing various cellular processes. Molecular glue compounds have gained significant attention in the fields of drug discovery, chemical biology, and fundamental research due to their potential to modulate protein interactions, and thus, impact various cellular pathways. They have unlocked avenues in medicine previously thought to be “undruggable.”

Cat. No.	製品名	CAS No.	Purity
T9849	HQ461	1226443-41-9	98%
T9849	HQ461 is a molecular glue that promotes CDK12-DDB1 interaction to trigger cyclin K degradation, resulting in decreased CDK12 substrate phosphorylation, downregul...
T0213	Thalidomide	50-35-1
T0213	Thalidomide (Thalomid) is a synthetic derivative of glutamic acid (alpha-phthalimido-glutarimide) with teratogenic, immunomodulatory, anti-inflammatory and anti-...
T22922	Lenalidomide hemihydrate	847871-99-2	100%
T22922	Lenalidomide hemihydrate is a TNF-α secretion inhibitor (IC50 = 13 nM). Lenalidomide hemihydrate could bound endogenous CRBN and recombinant CRBN-DNA damage bind...
T10703	Mezigdomide	2259648-80-9	97.21%
T10703	Mezigdomide (CC-92480) is a potent, novel, selective and active cereblon E3 ubiquitin ligase modulator (CELMoD) that often acts as a molecular glue. Mezigdomide ...
T2384	Pomalidomide	19171-19-8	98.8%
T2384	Pomalidomide (CC-4047) inhibits TNF-α release in LPS stimulated human PBMCs (IC50: 13 nM). It is an anti-angiogenic agent and an immunomodulator.
T10765	Eragidomide	1860875-51-9	99.41%
T10765	Eragidomide (CC-90009; Cereblon modulator 1) is a cereblon (CRBN) E3 ligase modulator. Eragidomide specifically binds to CRBN, thereby affecting the activity of ...
T1642	Lenalidomide	191732-72-6	99.5%
T1642	Lenalidomide (CC-5013) is a potent inhibitor of TNF-α that, at 10 μM, alters gene expression and cell viability in a range of cancer cell lines.
T67778	DCeMM1	118719-16-7	99.52%
T67778	dCeMM1 is a RBM39 glue degrader. dCeMM1 can re-direct the activity of the CRL4DCAF15 ligase. dCeMM1 can decrease the expression levels of RBM39 in WT KBM7 cells....
T61477	DCeMM2	296771-07-8	99.68%
T61477	dCeMM2 is a glue degrader. dCeMM2 prompts an interaction of CDK12-cyclin K with a CRL4B ligase complex, leading to the ubiquitination and degradation of cyclin K...
T81705	Naphthyridine carbamate dimer	864627-58-7	98%
T81705	Naphthyridine carbamate dimer (NCD) acts as a molecular glue for DNA, facilitating specific structural alterations within targeted functional DNA sequences to mo...
T79138	Antitumor agent-100 hydrochloride	2841750-53-4	98%
T79138	Antitumor agent-100 hydrochloride (compound A6), serving as both an apoptosis inducer and molecular glue, exhibits superior anti-tumor activity [1].
T60608	FPFT-2216	2367619-87-0	99.35%
T60608	FPFT-2216 is a "molecular glue" compound that degrades IKZF6, IKZF1, DE1D, and CK3α. FPFT-2216 has potential antitumor activity and can be used to study immune s...