Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Eragidomide (CC-90009; Cereblon modulator 1) is a cereblon (CRBN) E3 ligase modulator. Eragidomide specifically binds to CRBN, thereby affecting the activity of the ubiquitin E3 ligase complex.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 8,000 | |||
5 mg | 在庫あり | ¥ 18,500 | |||
10 mg | 在庫あり | ¥ 33,000 | |||
25 mg | 在庫あり | ¥ 68,500 | |||
50 mg | 在庫あり | ¥ 112,500 | |||
100 mg | 在庫あり | ¥ 166,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 18,500 |
説明 | Eragidomide (CC-90009; Cereblon modulator 1) is a cereblon (CRBN) E3 ligase modulator. Eragidomide specifically binds to CRBN, thereby affecting the activity of the ubiquitin E3 ligase complex. |
In vitro | Eragidomide demonstrated potent antiproliferative activity in 10 of 11 cell lines (e.g. NB4, U937, KG-1, MOLM-13, HL60 cells)with much less effect on the cell viability of PBMCs and THLE-2. The antiproliferative effect of Eragidomide is associated with apoptosis induction in all tested AML cell lines except OCI-AML3[1]. |
In vivo | In NOD/SCID mice, heterogeneous responses to the Eragidomide treatment (2.5mg/kg BID for 4 weeks) were observed. Of 35 AML samples tested, 16 were highly responsive to Eragidomide with >75% reduction of AML engraftment, 10 showed moderate response between 45% and 75% reductions, and 9 showed reductions of <25%. AML is clinically characterized by the accumulation of blasts that are impaired for differentiation and maturation. Eragidomide induced myeloid differentiation of AML blasts in the Eragidomide responders[3]. |
別名 | CC-90009, Cereblon modulator 1 |
分子量 | 461.85 |
分子式 | C22H18ClF2N3O4 |
CAS No. | 1860875-51-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 240 mg/mL (519.65 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Eragidomide 1860875-51-9 Apoptosis PROTAC Ligand for E3 Ligase Molecular Glues proteasome-mediated CRBN degradation CC-90009 E3 ligase-recruiting Moiety IKZF3 IRF4 IKZF1 c-myc Inhibitor anti-cancer Cereblon modulator 1 Ligands for E3 Ligase inhibit CC 90009 CC90009 T-lymphocytes inhibitor