Powder: -20°C for 3 years | In solvent: -80°C for 1 year
3-Methylxanthine, a xanthine derivative, is a cyclic guanosine monophosphate (GMP) inhibitor, with an IC50 of 920 μM on guinea-pig isolated trachealis muscle.3-Methylxanthine inhibited xanthine crystallization, it could protect patients with xanthinuria from the development of renal xanthine calculi.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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50 mg | 在庫あり | ¥ 7,500 | |||
100 mg | 在庫あり | ¥ 11,000 | |||
500 mg | 在庫あり | ¥ 26,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 12,000 |
説明 | 3-Methylxanthine, a xanthine derivative, is a cyclic guanosine monophosphate (GMP) inhibitor, with an IC50 of 920 μM on guinea-pig isolated trachealis muscle.3-Methylxanthine inhibited xanthine crystallization, it could protect patients with xanthinuria from the development of renal xanthine calculi. |
ターゲット&IC50 | GMP:920 μM (IC50) |
In vitro | To identify in vitro inhibitors of xanthine crystallization that have potential for inhibiting the formation of xanthine crystals in urine and preventing the development of the renal calculi in patients with xanthinuria. METHODS AND RESULTS: The formation of xanthine crystals in synthetic urine and the effects of 10 potential crystallization inhibitors were assessed using a kinetic turbidimetric system with a photometer. The maximum concentration tested for each compound was: 20 mg/L for 3-Methylxanthine (3-MX); 40 mg/L for 7-methylxanthine (7-MX), 1-methylxanthine (1-MX), theobromine (TB), theophylline, paraxanthine, and caffeine; 45 mg/L for 1-methyluric acid; 80 mg/L for 1,3-dimethyluric acid; and 200 mg/L for hypoxanthine. Scanning electron microscopy was used to examine the morphology of the crystals formed when inhibitory effects were observed. Only 7-MX, 3-MX, and 1-MX significantly inhibited xanthine crystallization at the tested concentrations. Mixtures of inhibitors had an additive effect rather than a synergistic effect on crystallization. CONCLUSIONS: Two of the inhibitors identified here-7-MX and 3-MX-are major metabolites of TB. In particular, after TB consumption, 20% is excreted in the urine as TB, 21.5% as 3-MX, and 36% as 7-MX. Thus, consumption of theobromine could protect patients with xanthinuria from the development of renal xanthine calculi. Clinical trials are necessary to demonstrate these effects in vivo. |
植物由来 |
分子量 | 166.14 |
分子式 | C6H6N4O2 |
CAS No. | 1076-22-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
1M NaOH: 50 mg/mL (300.95 mM), when pH is adjusted to 11 with 1 M NaOH. Sonication is recommended.
DMSO: 2.61 mg/mL (15.71 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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3-Methylxanthine 1076-22-8 Metabolism Endogenous Metabolite 3 Methylxanthine Inhibitor inhibit 3Methylxanthine inhibitor